Objective To study the effect of wall thickness on the accuracy(trueness and precision)of 3D printed models.Methods The 3D scanning data of the standard gypsum dental arch model was imported into Exocad software.And four sets of models were de-signed,including horseshoe shaped solid model and horseshoe shaped hollow models with different wall thicknesses(2 mm,3 mm,4 mm).On the first and seventh day after printing,the 3D scanning data of resin models were imported into Geomagic software.Deviation analysis were performed on 3D printed models for the root mean square(root mean square,RMS).Results The trueness range of the four groups of printed models on the first day was(34.63±4.17)μm to(45.26±6.50)μm,there was no statistical difference.The pre-cision range was(30.25±10.18)μm to(47.65±14.77)μm,and the precision of the solid group was lower than the other three groups(P＜0.05).The trueness range of the four groups of printing models on the 7th day was(49.00±9.11)μm to(69.25±9.70)μm.The trueness of the 2 mm wall thickness group was lower than that of the solid group and the 4 mum wall thickness group(P＜0.05).Con-clusion The accuracy of printing models with different wall thicknesses was within the clinical acceptance range.There was no statisti-cally significant difference in the trueness values of the four groups of printing models on the first day.The precision value of the solid group was the lowest.On the 7th day,the trueness of the wall thickness of 2 mm group was lower than that of the solid group and the 4 mum wall thickness group.

Objective:To compare the clinical outcomes of capsular closure versus those of non-closure in hip arthroscopy for femoroacetabular impingement (FAI) through a meta-analysis of randomized controlled trials (RCTs).Methods:A systematic search was conducted in Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Database for RCTs comparing capsular closure with non-closure in hip arthroscopy for FAI, covering the period from database inception to October 2024. A meta-analysis was performed using RevMan 5.3 software to compare outcomes between patients undergoing hip arthroscopy with capsular closure versus those without capsular closure within 2 years postoperatively. The following parameters were evaluated: the modified Harris hip score (mHHS), 12-item International Hip Outcome Tool (iHOT-12), hip outcome score-activities of daily living (HOS-ADL), hip outcome score-sport specific (HOS-SSS), Copenhagen hip and groin outcome score (HAGOS), visual analog scale (VAS) for pain, reoperation rate, complication rate, and rate of patient satisfaction.Results:A total of 5 RCTs involving 432 patients were included, with 215 cases in the capsular closure group and 217 cases in the non-closure group. The follow-up duration for the patients in the included studies ranged from 12 to 24 months. Meta-analysis revealed no significant differences between the capsular closure and non-closure groups in postoperative functional scores (mHHS, iHOT-12, HOS-SSS, HAGOS), VAS pain score, reoperation rate, complication rate, or rate of patient satisfaction ( P>0.05). The capsular closure group demonstrated significantly better HOS-ADL at 2 years postoperatively than the non-closure group (MD=-3.57, 95% CI: -5.86 to -1.28, P=0.002). Conclusion:In patients with FAI undergoing hip arthroscopy, compared to the non-closure, capsular closure leads to significant improvements in mid-term daily activities, but similar outcomes in short-term hip function, pain control, reoperation rate, and complication incidence.

OBJECTIVE To explore the epidemiological characteristics of the children with influenza A and influenza B in a hospital of Sichuan Province from 2019 to 2024 so as to provide bases for prevention and control of influen-zas.METHODS A total of 43,348 children with respiratory tract infections who underwent antigen tests for influ-enza A and influenza B viruses in pediatrics departments of Sichuan JinxinXinan Women and Children Hospital from Jan.2019 to Dec.2024 were recruited as the research subjects.The antigens were detected with colloidal gold method.The differences in prevalence intensity,seasons,age and genders were observed and compared be-tween the children with influenza A and those with influenza B.RESULTS The total positive rate of antigens was 24.19％among the children with influenzas,the positive rate of influenza A(A)virus antigen was 21.64％,and the positive rate of influenza B(B)virus antigen was 2.56％.There was significant difference in the positive rate of virus antigen between the influenza A and the influenza B among different years(P＜0.05).The positive rate of A virus antigen was 16.13％among infants,25.66％among preschool children,24.55％among school-age children;the positive rate of B virus antigen was 1.42％among infants,2.64％among preschool children,3.95％among school-age children;there were significant differences in the positive rates of antigens of A and B viruses among the different age groups(P＜0.05).The positive rate of A virus antigen was 22.22％among the male infants,21.00％among the female infants,and there was significant difference(P＜0.05);the positive rate of B virus an-tigen was 2.60％among the male infants,2.51％among the female infants,and there was no significant differ-ence.The positive rate of A virus antigen was 27.66％in spring,11.94％in summer,13.10％in autumn,21.98％in winter;the positive rate of B virus antigen was 1.21％in spring,0.09％in summer,1.62％in au-tumn,5.53％in winter;there were significant differences in the positive rates of antigens of A and B viruses a-mong the seasons(P＜0.05).CONCLUSIONS The total positive rate of influenza A virus antigen is higher than that of the influenza B virus antigen.There is difference in the susceptible population between the influenza A and the influenza B;the influenza A is highly prevalent in winter and spring,and the influenza B is highly prevalent in winter.

Objective To study the effect of wall thickness on the accuracy(trueness and precision)of 3D printed models.Methods The 3D scanning data of the standard gypsum dental arch model was imported into Exocad software.And four sets of models were de-signed,including horseshoe shaped solid model and horseshoe shaped hollow models with different wall thicknesses(2 mm,3 mm,4 mm).On the first and seventh day after printing,the 3D scanning data of resin models were imported into Geomagic software.Deviation analysis were performed on 3D printed models for the root mean square(root mean square,RMS).Results The trueness range of the four groups of printed models on the first day was(34.63±4.17)μm to(45.26±6.50)μm,there was no statistical difference.The pre-cision range was(30.25±10.18)μm to(47.65±14.77)μm,and the precision of the solid group was lower than the other three groups(P＜0.05).The trueness range of the four groups of printing models on the 7th day was(49.00±9.11)μm to(69.25±9.70)μm.The trueness of the 2 mm wall thickness group was lower than that of the solid group and the 4 mum wall thickness group(P＜0.05).Con-clusion The accuracy of printing models with different wall thicknesses was within the clinical acceptance range.There was no statisti-cally significant difference in the trueness values of the four groups of printing models on the first day.The precision value of the solid group was the lowest.On the 7th day,the trueness of the wall thickness of 2 mm group was lower than that of the solid group and the 4 mum wall thickness group.

OBJECTIVE To explore the epidemiological characteristics of the children with influenza A and influenza B in a hospital of Sichuan Province from 2019 to 2024 so as to provide bases for prevention and control of influen-zas.METHODS A total of 43,348 children with respiratory tract infections who underwent antigen tests for influ-enza A and influenza B viruses in pediatrics departments of Sichuan JinxinXinan Women and Children Hospital from Jan.2019 to Dec.2024 were recruited as the research subjects.The antigens were detected with colloidal gold method.The differences in prevalence intensity,seasons,age and genders were observed and compared be-tween the children with influenza A and those with influenza B.RESULTS The total positive rate of antigens was 24.19％among the children with influenzas,the positive rate of influenza A(A)virus antigen was 21.64％,and the positive rate of influenza B(B)virus antigen was 2.56％.There was significant difference in the positive rate of virus antigen between the influenza A and the influenza B among different years(P＜0.05).The positive rate of A virus antigen was 16.13％among infants,25.66％among preschool children,24.55％among school-age children;the positive rate of B virus antigen was 1.42％among infants,2.64％among preschool children,3.95％among school-age children;there were significant differences in the positive rates of antigens of A and B viruses among the different age groups(P＜0.05).The positive rate of A virus antigen was 22.22％among the male infants,21.00％among the female infants,and there was significant difference(P＜0.05);the positive rate of B virus an-tigen was 2.60％among the male infants,2.51％among the female infants,and there was no significant differ-ence.The positive rate of A virus antigen was 27.66％in spring,11.94％in summer,13.10％in autumn,21.98％in winter;the positive rate of B virus antigen was 1.21％in spring,0.09％in summer,1.62％in au-tumn,5.53％in winter;there were significant differences in the positive rates of antigens of A and B viruses a-mong the seasons(P＜0.05).CONCLUSIONS The total positive rate of influenza A virus antigen is higher than that of the influenza B virus antigen.There is difference in the susceptible population between the influenza A and the influenza B;the influenza A is highly prevalent in winter and spring,and the influenza B is highly prevalent in winter.

Objective:To compare the clinical outcomes of capsular closure versus those of non-closure in hip arthroscopy for femoroacetabular impingement (FAI) through a meta-analysis of randomized controlled trials (RCTs).Methods:A systematic search was conducted in Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Database for RCTs comparing capsular closure with non-closure in hip arthroscopy for FAI, covering the period from database inception to October 2024. A meta-analysis was performed using RevMan 5.3 software to compare outcomes between patients undergoing hip arthroscopy with capsular closure versus those without capsular closure within 2 years postoperatively. The following parameters were evaluated: the modified Harris hip score (mHHS), 12-item International Hip Outcome Tool (iHOT-12), hip outcome score-activities of daily living (HOS-ADL), hip outcome score-sport specific (HOS-SSS), Copenhagen hip and groin outcome score (HAGOS), visual analog scale (VAS) for pain, reoperation rate, complication rate, and rate of patient satisfaction.Results:A total of 5 RCTs involving 432 patients were included, with 215 cases in the capsular closure group and 217 cases in the non-closure group. The follow-up duration for the patients in the included studies ranged from 12 to 24 months. Meta-analysis revealed no significant differences between the capsular closure and non-closure groups in postoperative functional scores (mHHS, iHOT-12, HOS-SSS, HAGOS), VAS pain score, reoperation rate, complication rate, or rate of patient satisfaction ( P>0.05). The capsular closure group demonstrated significantly better HOS-ADL at 2 years postoperatively than the non-closure group (MD=-3.57, 95% CI: -5.86 to -1.28, P=0.002). Conclusion:In patients with FAI undergoing hip arthroscopy, compared to the non-closure, capsular closure leads to significant improvements in mid-term daily activities, but similar outcomes in short-term hip function, pain control, reoperation rate, and complication incidence.

Colorectal cancer (CRC) is one of the most common digestive system tumors and the second most common tumor in the world in terms of mortality. The current chemotherapeutic drugs applied in clinical treatment seriously affect the survival quality of patients due to adverse reaction and susceptibility to chemoresistance. Therefore, it is necessary to search for novel anti-CRC drugs. As natural compounds, polyphenols components of traditional Chinese medicine can exert anti-CRC properties through various mechanisms, such as promoting apoptosis, inhibiting cell proliferation, and inducing iron death. In addition, it can reverse the resistance of CRC cells to chemotherapeutic drugs. Further exploration of the anti-CRC action mechanism of polyphenols constituents of traditional Chinese medicine may provide a certain reference basis for clinical application.

Objective:To evaluate the efficacy of stage one external unilateral frame fixation combined with stage two internal plate fixation in the femoral bone transport for femoral defects or deformity.Methods:A retrospective study was conducted to analyze the clinical data of 24 patients who had been treated by femoral bone transport for femoral defects or deformity at Department of Orthopaedic Surgery, The Fourth Hospital of Wuhan from January 2013 to January 2023. There were 16 males and 8 females with an age of (46.2±14.7) years. The causes for femoral bone transport were infectious bone defects caused by trauma or surgery in 13 cases, congenital length disparity of bilateral femurs in 6 cases, and chronic femoral osteomyelitis caused by non-traumatic factors in 5 cases. All patients were treated by external fixation with an unilateral frame to carry out femoral bone transport at stage one followed by internal plate fixation after the femoral bone transport was completed at stage two. Postoperative complications, functional recovery of the lower extremity at 12 months after internal fixation and quality of life were recorded.Results:The 24 patients were followed up for (30.2±8.6) months. The stretch velocity of bone elongation was (0.87±0.04) mm/d, the external fixation time (4.2±1.4) months, the duration between internal plate fixation and end of bone transport (8.2±4.9) weeks, and the bony union time (15.9±4.7) months. None of the 24 patients experienced severe limb infection, and their wounds healed without any neurovascular lesions. By the Paley scoring criteria, the lower limb function at 12 months after internal fixation was assessed as excellent in 16 cases, as good in 6 cases, and as fair in 2 cases, giving an excellent and good rate of 91.7% (22/24). By the SF-36 Quality of Life Assessment Form, the quality of life of the patients scored (87.9±4.1) points.Conclusion:In the femoral bone transport for femoral defects or deformity, the sequential strategy of external unilateral frame fixation at stage one combined with internal plate fixation at stage two can avoid complications caused by long-term frame carrying, reduce incidence of delayed union, and enhance the quality of life of patients.

Objective:To analyze the clinical efficacy of arthroscopic transverse release of the iliotibial band through peritrochanteric space for the treatment of external snapping hip.Methods:A total of 30 patients (12 males and 18 females) with bilateral external snapping hip underwent arthroscopic transverse release of the iliotibial band through peritrochanteric space in Department of Sports Medicine, Senior Department of Orthopaedics, the Fourth Medical Center, Chinese PLA General Hospital were retrospectively analyzed from May 2021 and June 2022. The average age was 32.5±8.2 years (range, 17-51 years). At the same time, 30 patients who underwent arthroscopic external release of the iliotibial band through the external surface of the iliotibial band (external iliotibial band group) were selected as control group, including 13 males and 17 females, aged 29.5±6.8 years (range, 11-45 years). The visual analogue scale (VAS), modified Harris hip score (mHHS), and gluteal muscle contracture disability scale (GDS) were compared between the two groups at preoperative, 6 months postoperative, and final follow-up.Results:All patients successfully completed the operation and were followed up for 17.5±3.3 months (range, 12-25 months). The VAS scores of the two groups at the last follow-up were lower than those before operation ( P<0.05). The mHHS scores before operation, 6 months after operation and at the last follow-up in the peritrochanteric space group were 76.5 (67.0, 85.5), 98.5 (94.8, 100.0) and 100.0 (97.0, 100.0), respectively, and those in the external iliotibial band group were 80.5 (70.0, 86.0), 100.0 (96.0, 100.0) and 100.0 (99.5, 100.0). The differences in mHHS scores between the two groups were statistically significant for intragroup comparisons ( P<0.05); of these, 6 months postoperatively and at the last follow-up were greater than preoperatively, with statistically significant differences ( P<0.05); the differences at 6 months postoperatively and at the last follow-up were not statistically significant ( P>0.05). There was no significant difference in mHHS scores between groups at different time points ( P>0.05). The GDS before operation, at 6 months after operation and at the last follow-up were 47.0 (35.8, 64.5), 90.0 (81.0, 94.0) and 93.5 (89.8, 98.0) in the peritrochanteric space group, and 51.0 (38.0, 64.5), 50.0 (81.0, 94.0) and 93.5 (89.8, 98.0) in the external iliotibial band group, respectively. The differences in GDS between the two groups were statistically significant for intragroup comparisons ( P< 0.05); of these, 6 months postoperatively and at the last follow-up were greater than preoperatively, with statistically significant differences ( P<0.05); the differences at 6 months postoperatively and at the last follow-up were not statistically significant ( P>0.05). There was no significant difference in GDS between groups at different time points ( P>0.05). Conclusion:Arthroscopic transverse release of the iliotibial band through peritrochanteric space for the treatment of external snapping hip can effectively reduce hip pain and improve hip function, with satisfactory clinical results, and can be used as an alternative treatment to transverse release through the external surface of the iliotibial band.

Objective:To analyze the effect of mucosal ligament preservation on the outcome of arthroscopic repair of meniscus injury.Methods:A total of 77 patients with knee meniscus tears caused by sports injuries who underwent arthroscopic meniscus repair or suture in Zhengzhou Orthopaedic Hospital from June 2022 to June 2023, were retrospectively analyzed. Including 45 males and 32 females, aged 38.57±13.54 years (range, 52-87 years), body mass index 24.72±4.01 kg/m 2 (range, 34.14-13.61 kg/m 2). All patients complained of knee pain, limited activity and walking weakness. The symptoms were not relieved after 1 month of conservative treatment, which seriously affected daily work and life. According to the intraoperative treatment of mucosal ligament, the patients were divided into mucosal ligament preservation group and mucosal ligament removal group. The visual analogue score (VAS), Lysholm score, and total blood loss were compared between the two groups. Results:All patients successfully completed the operation and were followed up for an average of 5.23±2.16 months (range, 3-9 months). The operation time was 47.59±16.81 min in mucosal ligament preservation group and 45.25±15.93 min in mucosal ligament removal group, and there was no significant difference between the two groups ( t=0.628, P=0.532). The total blood loss in the mucosal ligament preservation group was 246±193 ml, which was less than 343±211 ml in the mucosal ligament removal group, and the difference was statistically significant ( t=2.095, P=0.040). None of the patients received allogeneic blood transfusion. The hematocrit of the mucosal ligament preservation group was 42.48%±4.57% before operation and 39.42%±4.65% on the third day after operation, while that of the mucosal ligament removal group was 41.24%±4.16% and 38.95%±3.80%. The difference between the two groups was statistically significant ( t=0.016, P=0.004; t=0.004, P=0.016). There was no significant difference between the two groups before operation and on the third day after operation ( t=0.217, P=0.545; t=0.629, P=0.159). The preoperative VAS score of mucosal ligament preservation group was 7.25±1.10, which was higher than that of 3 months after operation (0.83±1.06), and the difference was statistically significant ( t=0.062, P<0.001). The preoperative VAS score of mucosal ligament removal group was 7.16±1.21, which was higher than that of 3 months after operation (1.05±1.13), and the difference was statistically significant ( t=0.017, P<0.001). There was no significant difference in VAS scores between the two groups before operation and at 3 months after operation ( t=0.144, P=0.740; t= 0.273, P=0.603). The preoperative Lysholm score of mucosal ligament preservation group was 31.76±7.54, which was significantly lower than that of 3 months after operation 87.30±4.12 ( t=-39.329, P<0.001); The Lysholm score of the mucosal ligament removal group was 34.13±7.32 before operation, which was lower than 89.05±4.45 at 3 months after operation, and the difference was statistically significant ( t=-40.172, P<0.001); There was no significant difference in Lysholm score between the two groups before operation and 3 months after operation ( t=1.395, P=0.167; t=1.766, P=0.081). Conclusion:The preservation of mucosal ligament in arthroscopic surgery for meniscus injury does not prolong the operation time. It can reduce the total intraoperative blood loss, and the postoperative knee function recovery is similar to that of mucosal ligament removal.