Paraffin sections of atherosclerotic vessels were classified into initial lesion, preatheroma and complicated severe lesion by classification method from American Heart Association. Activation of NF-kappaB was hardly detectable in the initial atherosclerotic lesion. In the preatheroma, activated NF-kappaB was enhanced in the neointimal smooth muscle cells and macrophages in the lipid core. In contrast, activated NF-kappaB increased markedly in the neointimal and medial smooth muscle cells in the severe atherosclerotic vessel wall. However, in the severe lesion, NF-kappaB activation was diminished in the macrophages of lipid core. Our findings show that NF-kappaB was activated in the smooth muscle cells with the progression of atherosclerosis in the human coronary artery.
American Heart Association ; Atherosclerosis ; Classification ; Coronary Vessels* ; Humans* ; Macrophages ; Myocytes, Smooth Muscle ; NF-kappa B ; Paraffin

Crohn's disease is one of the chronic inflammatory disorders of unknown cause involving the gastrointestinal tract. The inflammation may occur in the colon, either alone or with small intestine. Crohn's disease has been associated with increased risk for coloretal carcinoma in patients with long-standing colitis, strictures and fistulae. Recently, we experienced a case of Crohn's disease complicating carcinoma in a 85 year old male. Ten years ago, he compained severe abdominal pain and diarrhea. and was detected colon obstruction and enteric fistula. But, he spontaneously improved. Recently, the patient was admitted complaining abdominal pain. He complaind abdominal pain and indigestion chronically and aggravated recently. He was examined with colonofibroscopy, and computered tomography, and carcinoma was detected at the site of Crohn's disease.
Abdominal Pain ; Aged, 80 and over ; Colitis ; Colon* ; Colorectal Neoplasms ; Constriction, Pathologic ; Crohn Disease* ; Diarrhea ; Dyspepsia ; Fistula ; Gastrointestinal Tract ; Humans ; Inflammation ; Intestine, Small ; Male

Three hundred patients who have congenital colour vision deficiencies were examined at the author's eye clinic for 3 years (1987-1990) using 5 types of colour vision tests: Hahn's, TMC's, Okuma's (new), H-R-R's colour vision tests and Double 15 Hue Test (Hahn). The results obtained from each test were quite different in type and grade, and the summarized results were considered to be the best: Type: protan 23.3%, deutan 76.0%, unclassified 0.7% Grade: mild 20.3%, medium 25.3%, strong 54.4% The frequency of coincidence both in type and grade between the summarized results and those of each test were compared, and the highest was 62.3% in Double 15 Hue Test. The efficiency of the author's colour vision test and Double 15 Hue Test were evaluated with the data in this clinical trial, and they were found to be useful for classifying the type and estimating the grade of the congenital and also acquired colour vision deficiencies.
Adolescent ; Adult ; Child ; Color Perception Tests ; Color Vision Defects/*congenital/diagnosis ; Evaluation Studies as Topic ; Female ; Humans ; Male ; Middle Aged

The accuracy of vision test chart is very important in examination of the visual acuity. The author examined the accuracy of the Cheongsan Vision Chart which is an imitative print of Dr. Chun Suk Hahn's Vision Test Chartby measuring it's test types of Landolt's rings, Arabic figures, Korean letters and pictures in detail with micrometer and surgical loupe. The errors in size of test types of Cheongsan Vision Chart to the standard size which was authorized by the Ministry of Health and Social Affairs of Korea in 1972 for the Chun Suk Hahn's Vision Test Chart are found as follows: 1. Error in Landolt's rings. 0.2-32.7%, av. 9.0%. Error over+/-10% in 35.7%. 2. Error in Arabic figures. 0.1-70.4% av. 12.8%. Error over+/-10% in 47.6%. 3. Error in Korean letters. 0.2-55.9% av. 15.4%. Error over+/-10% in 57.1%. 4. Error in pictures. 0.2-15.1% av. 0.9%. Error over+/-10% in 8.1%. In this study the author found that the Cheongsan Vision Chart is lacking in accuracy for examination of visual acuity.
Aphakia ; Arabs ; Argon* ; Filtering Surgery ; Glaucoma ; Glaucoma, Angle-Closure ; Humans ; Korea ; Uveitis ; Vision Tests ; Visual Acuity

1. A simplified vision test chart which is composed of test types of arabic figures and Landolt's rings for 0.1, 0.3, 0.5, 0.8 and 1.0 was designed by the author. 2. The test chart may be used at school for screeing the students who have decreased vision in early stage, and so school myopia can be prevented or cured by medical treatment. 3. It is also recommended to be used for testing the vision of students once every month at home to preserve good vision and prevent school myopia which is so much increased among the students that it has become a serious social problem in Korea.
Arabs ; Humans ; Korea ; Mass Screening* ; Myopia ; Social Problems ; Vision Tests*

1. A simplified vision test chart which is composed of test types of arabic figures and Landolt's rings for 0.1, 0.3, 0.5, 0.8 and 1.0 was designed by the author. 2. The test chart may be used at school for screeing the students who have decreased vision in early stage, and so school myopia can be prevented or cured by medical treatment. 3. It is also recommended to be used for testing the vision of students once every month at home to preserve good vision and prevent school myopia which is so much increased among the students that it has become a serious social problem in Korea.
Arabs ; Humans ; Korea ; Mass Screening* ; Myopia ; Social Problems ; Vision Tests*

The vascular reaction such as the indirect blood pressure and the pulse rate of the tail to the noise were examined in 8 naive Sprague-Dawley rats of both sexes. The sounds used in the experiment were 1KHz and 4 KHz, 95dB pure tone generated by Nagashima Audiometry. The indirect blood pressure and the pulse rate were checked at the rat tail by Polygraph at 5 minutes interval. The results were as follows: 1. The blood pressure and the pulse rate increased maximally 5 minutes after the exposure to both sounds. 2. The blood pressure and the pulse rate returned normal range within 20 minutes after the exposure of both sounds. 3. The increment of the blood pressure and the pulse rate was greater after the sound of 4KHz than after that of 1 KHz, but it wasn't statistically significant.
Animals ; Audiometry ; Blood Pressure* ; Heart Rate ; Noise* ; Rats* ; Rats, Sprague-Dawley ; Reference Values ; Tail

The Hahn Pseudoisochromatic Plates were used to test the color sense of 100 color defective subjects. Results and data obtained from the test showed the plates to be practically useful in screening. qualitative and quantitative diagnostic test for congenital color defective subjects.
Diagnostic Tests, Routine ; Mass Screening

The Double 15-Hue Test. designed by the author in 1977, was used to examine the color sense of 100 color defective subjects. Results and data obtained from the test showed that it is of more value than pseudoisochromatic plates in qualitative and quantitative diagnosis of the defective color sense because of its accuracy, simplicity and objectivity.
Diagnosis

The Double 15-Hue Test was designed to classify the types of congenital defective color vision as protan, deutan and tritan, and also to estimate its extent as strong(grade 3), medium(grade 2) and mild (grade 1) defects. This is a paired dichotomous test: Test A and B. Test A is a modified Farnsworth's Panel D-15 Test for separating the subject with strong defect from those with medium and mild defects, while Test B composing more desaturated color chips is used to separate the subject with mild defect from those with strong and medium defects. The test was evaluated with 72 color defective students detected at two high schools using Ishihara's and the author's pseudoisochromatic plates, and it was proved to be very helpful for qualitative and quantitative diagnosis of defective color vision.
Color Vision ; Congenital Abnormalities ; Diagnosis ; Humans