Objective To provide better health management for pilots by retrospective study of the disease spectrum of China Southern pilots in 2017. Methods The retrospective study method was applied to estimate the detection rate of related disease of 1 826 pilots who participated in the physical examination in 2017.The detection rates of related diseases were compared among 4 age groups (20-29 yrs ,30-39 yrs ,40-49 yrs and ＞50 yrs). Results Among 1 826 pilots ,the top ten diseases were hyperlipidemia ,fatty liver ,hyperuricemia ,presbyopia ,gallbladder polyp ,ametropia , hearing loss ,obesity ,vision loss and renal cysts.Among different age groups ,the detection rates of hyperlipidemia ,fatty liver ,hyperuricemia ,presbyopia ,gallbladder polyp ,ametropia ,hearing loss , obesity ,vision loss ,renal cysts and hypertension were significantly different (χ2＝10.456-193.402 , P＜0.05).And the detection rates of fatty liver ,hearing loss ,obesity ,renal cysts and hypertension increased with age significantly. Conclusions The risk factors of cardiovascular disease in pilots are prominent.And the detection rates of the metabolic related diseases and the decreased audio-visual function are high in them.Controlling the body weight ,uric acid and blood lipid would be critical to pilot′s health management.

Objective To provide better health management for pilots by retrospective study of the disease spectrum of China Southern pilots in 2017. Methods The retrospective study method was applied to estimate the detection rate of related disease of 1 826 pilots who participated in the physical examination in 2017.The detection rates of related diseases were compared among 4 age groups (20-29 yrs ,30-39 yrs ,40-49 yrs and ＞50 yrs). Results Among 1 826 pilots ,the top ten diseases were hyperlipidemia ,fatty liver ,hyperuricemia ,presbyopia ,gallbladder polyp ,ametropia , hearing loss ,obesity ,vision loss and renal cysts.Among different age groups ,the detection rates of hyperlipidemia ,fatty liver ,hyperuricemia ,presbyopia ,gallbladder polyp ,ametropia ,hearing loss , obesity ,vision loss ,renal cysts and hypertension were significantly different (χ2＝10.456-193.402 , P＜0.05).And the detection rates of fatty liver ,hearing loss ,obesity ,renal cysts and hypertension increased with age significantly. Conclusions The risk factors of cardiovascular disease in pilots are prominent.And the detection rates of the metabolic related diseases and the decreased audio-visual function are high in them.Controlling the body weight ,uric acid and blood lipid would be critical to pilot′s health management.

MicroRNAs ( miRNAs ) play important roles in the processes of the occurrence and development of cancers , through regulating tumor related gene expression at post-transcription.It has shown that the expression of miR-214 is aberrant in cervi-cal cancer.Also,miR-214 could affect the proliferation, migration, invasion and apoptosis of tumor cells by targeting various genes . This article focuses on the studies of miR-214 function in cervical cancer , and will provide a novel approach for the clinical diagnosis and the treatment of cervical cancer .

OBJECTIVETo assess the association of four single nucleotide polymorphisms (SNPs) (rs12190359C>T, rs562047C>G, rs1008438G>T, and rs1043618G>C) of HSPA1A gene with the development of cervical cancer among ethnic Han Chinese from Yunnan.

METHODSOne hundred and thirty patients with CIN III, 444 patients with cervical cancer, and 548 healthy individuals were recruited, and the genotypes of the above SNPs were determined with a Taqman assay. Haplotypes were constructed, and their association with the development of cervical cancer was analyzed.

RESULTSThe frequencies of G and T alleles of rs1008438G>T were significant different between the CIN III and control groups, as well as between the cancer and control groups (P=0.022 and P=0.030, respectively). There was a significant difference in genotypic frequency of rs1008438G>T between the CIN III and control groups (P=0.047). The allelic and genotypic frequencies of rs12190359C>T, rs562047C>G, and rs1043618G>C did not significantly differ between the CIN III, cervical cancer and control groups (P> 0.05). The frequencies of haplotypes formed by rs562047C>G, rs1008438G>T and rs1043618G>C also did not significantly differ between the CIN III, cancer and control groups (P> 0.05).

CONCLUSIONThe G allele of rs1008438G>T may be a protective factor for cervical cancer among ethnic Han Chinese from Yunnan.

China ; ethnology ; Female ; Genetic Predisposition to Disease ; Genotype ; HSP70 Heat-Shock Proteins ; genetics ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide ; Uterine Cervical Neoplasms ; etiology ; genetics

Objective To provide aeromedical management reference for preventing and controlling the overweight and obesity in pilots by a retrospective analysis on body mass index (BMI) and related diseases for the pilots of a civil airline in 2015.Methods The method of retrospective study was applied on 3 134 civil pilots who accepted annual physical examination in 2015 and were grouped by age.The detection rate of abnormal body mass index (BMI≥24 kg/m2) was compared among different age groups and the relationship between BMI and age was analyzed.The pilots also grouped by the level of BMI.The prevalence rate of hypertension,hyperlipidemia and other diseases were compared among different BMI groups,as well as such physiological and biochemical indexes as total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) and fasting plasma glucose (FPG).Results Age and BMI of the civil aviation pilots were weak positive correlation (r=0.232,P＜0.05).The detection rate of hypertension,hyperlipidemia,combined hyperlipidemia familial,hyperuricemia,fatty liver,impaired glucose tolerance and diabetes increased significantly with the increasing of BMI (x2 =7.783-476.795,P＜0.05).The age and physiological and biochemical indexes of TC,TG,HDL,LDL-C and FPG were significantly different among different BMI groups (F=16.046-157.706,P＜0.05).Conclusions BMI is an important risk indicator for hypertension,fatty liver,hyperlipidemia and diabetes.The individualized management of controlling the pilot's BMI in a normal range is an important measure to prevent the cardiovascular diseases.

Objective To provide aeromedical management reference for preventing and controlling the overweight and obesity in pilots by a retrospective analysis on body mass index (BMI) and related diseases for the pilots of a civil airline in 2015.Methods The method of retrospective study was applied on 3 134 civil pilots who accepted annual physical examination in 2015 and were grouped by age.The detection rate of abnormal body mass index (BMI≥24 kg/m2) was compared among different age groups and the relationship between BMI and age was analyzed.The pilots also grouped by the level of BMI.The prevalence rate of hypertension,hyperlipidemia and other diseases were compared among different BMI groups,as well as such physiological and biochemical indexes as total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) and fasting plasma glucose (FPG).Results Age and BMI of the civil aviation pilots were weak positive correlation (r=0.232,P＜0.05).The detection rate of hypertension,hyperlipidemia,combined hyperlipidemia familial,hyperuricemia,fatty liver,impaired glucose tolerance and diabetes increased significantly with the increasing of BMI (x2 =7.783-476.795,P＜0.05).The age and physiological and biochemical indexes of TC,TG,HDL,LDL-C and FPG were significantly different among different BMI groups (F=16.046-157.706,P＜0.05).Conclusions BMI is an important risk indicator for hypertension,fatty liver,hyperlipidemia and diabetes.The individualized management of controlling the pilot's BMI in a normal range is an important measure to prevent the cardiovascular diseases.

Objective To provide the scientific basis for the prevention and control of hypertension by analyzing the related risk factors for prolonging pilot's career.Methods Two thousand seven hundred and fifty-five pilots examined in 2013 were divided into different groups by age to compare the abnormal rate of blood pressure among groups.Such biochemical indicators as the prevalence of hyperglycemia and the hyperlipidemia were also analyzed for the comparison of normal blood pressure and hypertension.Results In 2 755 examined pilots,the cases of primary hypertension were 71 cases,and the prevalence rate was 2.58％.Prevalence of hypertension significantly increased with age (x2=64.704,P＜0.01).Triglyceride (TG),fasting plasma glucose (FPG),body mass index (BMI) in hypertension group was significantly higher than that in normal blood pressure group (t=3.173-5.684,P＜0.01).Conclusions Age,BMI,blood fat and blood sugar level are the significant risk factors of hypertension in civil aviation pilots.Prevention and control of the risk factors of the cardiovascular disease could be useful to restrict pilot's hypertension.

Objective To provide the scientific basis for the prevention and control of hypertension by analyzing the related risk factors for prolonging pilot's career.Methods Two thousand seven hundred and fifty-five pilots examined in 2013 were divided into different groups by age to compare the abnormal rate of blood pressure among groups.Such biochemical indicators as the prevalence of hyperglycemia and the hyperlipidemia were also analyzed for the comparison of normal blood pressure and hypertension.Results In 2 755 examined pilots,the cases of primary hypertension were 71 cases,and the prevalence rate was 2.58％.Prevalence of hypertension significantly increased with age (x2=64.704,P＜0.01).Triglyceride (TG),fasting plasma glucose (FPG),body mass index (BMI) in hypertension group was significantly higher than that in normal blood pressure group (t=3.173-5.684,P＜0.01).Conclusions Age,BMI,blood fat and blood sugar level are the significant risk factors of hypertension in civil aviation pilots.Prevention and control of the risk factors of the cardiovascular disease could be useful to restrict pilot's hypertension.

Objective To investigate the sleep quality of teachers from preschool institution and related factors.Methods Totally 220 teachers of various preschool institution in Shandong and Beijing were selected by cluster sampling and surveyed with questionnaire including Pittsburgh sleep quality index (PSQI).Results ①There were 27.7％ of the teachers having sleeping problems.②There was statistical significance by sleep disorder,using of sleep medications,daytime dysfunction,the PSQI scores of groups were significantly different (P ＜0.05).③Age of 36 ～ 40 years old (2.00 ± 0.71),married teachers (1.57 ± 0.72),seniority in 36 ～ 40 years,length of service in 13-17 years (1.75 ± 1.03) and ＞ 18 years (1.76 ± 0.66),form teacher(1.50 ± 0.71),formal staff teachers(1.63 ± 0.71)in sleep disorder were significantly higher than other teachers in their group and the difference was significant (P ＜ 0.05).College degree (0.22 ± 0.68),private kindergarden teachers (0.65 ± 0.90)in using of sleep medications were significantly higher than other teachers in their group,the difference was significant (P ＜ 0.05).formal staff teachers (1.33 ± 0.77) in daytime dysfunction were significantly higher than other teachers in their group and the difference was significant(P＜ 0.05).@The multiple factor logistic regression analysis demonstrated that sleeping quality of preschool institution ’s teachers were associated with having breakfast,regular diet,work breaks,insist on physical excise,Job burnout.Conclusion The sleep disorder is serious among teachers of preschool institution.