Objective To conduct a visualization analysis of acupuncture treatment for cervical spondylosis of vertebral artery type(CSA)using CiteSpace and VOSviewer,exploring the current research status and development trends in this field,and providing evidence and recommendations for future studies.Methods Journal articles on acupuncture treatment for CSA were retrieved from the China National Knowledge Infrastructure(CNKI)database from its inception to September 14,2024.Excel 2021,VOSviewer(1.6.20),and CiteSpace(5.7r5)were used to perform visualization analyses of author output,journal publications,research institutions,collaboration networks,and keywords,with knowledge maps generated accordingly.Results A total of 2 769 articles were retrieved,and after screening,1 874 articles were included.The publication output in the field of acupuncture for CSA generally showed an increasing trend.There were 129 authors who published≥3 articles,with the top three being Jia Hongling,Zhang Yongchen,and Wang Xilin.A total of 277 journals published relevant articles,with the Shanghai Journal of Acupuncture and Moxibustion being the most prolific.Research institutions were primarily represented by Tianjin University of Traditional Chinese Medicine and Hubei University of Chinese Medicine.The number of institutions in this field was large and widely distributed,yet independent.Due to geographical and other factors,cross-regional collaborations were limited.Keyword co-occurrence analysis revealed that,apart from"cervical spondylosis of vertebral artery type",the most frequently occurring terms included cervical spondylosis,acupuncture,tuina,acupuncture therapy,electroacupuncture,vertigo,hemodynamics,therapeutic effect,acupotomy,and warm needling.Cluster analysis mainly identified different acupuncture therapies,acupoint selection patterns,and clinical research related to CSA.Conclusion Clinical research on acupuncture for CSA is active,but mechanistic studies remain relatively insufficient.Future research should focus on elucidating the underlying mechanisms to provide new insights.Additionally,studies in this field are highly fragmented,lacking extensive collaboration among authors and institutions.Research teams should strengthen cooperation and diversify their approaches to further advance the study of acupuncture for CSA.

BACKGROUND:Numerous clinical studies have suggested a close relationship between obesity and osteoporosis,but whether there is a genetic causal effect between obesity and osteoporosis remains unclear. OBJECTIVE:To explore the association between obesity and osteoporosis using summary data from a large-scale genome-wide association study(GWAS)through Mendelian randomization analysis. METHODS:Obesity data were derived from summary statistics of the Genetic Investigation of Anthropometric Traits(GIANT)and the UK Biobank(UKBB).Osteoporosis data were obtained from the Genetic Factors for Osteoporosis(GeFOS)consortium,including two bone density phenotypes:total body bone mineral density(BMD)and heel BMD.The inverse variance-weighted method was the primary analysis,with the Mendelian randomization method based on Egger regression(MR-Egger)and weighted median method as supplementary approaches to calculate the causal association between genetic variations related to obesity and osteoporosis.Sensitivity analyses were conducted to validate the reliability of the results.Heterogeneity was assessed using Cochran's Q test.Horizontal pleiotropy was assessed through the MR-Egger intercept test.Leave-one-out analysis was performed to evaluate the potential influence of single nucleotide polymorphisms on the combined inverse variance-weighted estimates. RESULTS AND CONCLUSION:(1)Impact of obesity on osteoporosis:In addition to body mass index and forearm BMD,body mass index,waist-to-hip ratio,body mass index-adjusted waist-to-hip ratio,and whole-body body mass index,heel BMD,forearm BMD,lumbar spine BMD,and femoral neck BMD were causally related to each other.Further Meta-analysis revealed that obesity increased the risk of BMD(odds ratio=1.07,95%confidence interval:1.03-1.12,P<0.01).(2)Impact of osteoporosis on obesity:Apart from arm BMD and lumbar spine BMD as exposure factors showing causal relationships with obesity,other datasets indicated no causal effect between total body BMD,heel BMD,femoral neck BMD,and obesity.Additional meta-analysis demonstrated that BMD did not increase the risk of obesity(odds rate=0.99,95%confidence interval:0.98-1.01,P<0.01).There is a causal relationship between obesity and osteoporosis,suggesting that obesity may be a risk factor for osteoporosis.However,no causal association is found between osteoporosis and obesity.