As a new manner of cell death,cuproptosis depends on the accumulation of copper ions in cells.Copper ion is an essential trace element in normal physiological state of organisms.The excess of free copper in cells not only has toxic effect on normal cells,but also plays its specific killing function on tumor cells.Copper transporter 1(CTR1)is a key transporter of transmembrane uptake of copper ions by cells.As a regulator of cuproptosis,its mutation and expression changes in tumors have an impact on the distribution of copper ions inside and outside the cells.It may participate in multiple biological processes such as proliferation,invasion and migration of tumor cells by regulating the pathway of cuproptosis.This article reviews the cuproptosis pathway mediated by CTR1 and the potential value of CTR1 in tumor treatment,elaborates the importance of copper ion homeostasis regulation for normal life activities and the mechanism of CTR1 in regulating cuproptosis,and discusses the potential value of CTR1 as a new target for tumor therapy,so as to provide a theoretical basis for the treatment of tumor patients.

In the context of medical insurance payment reform,the sample hospital has implemented performance management optimization to effectively address the challenges posed by diagnosis-intervention packet(DIP)payment.Reform measures focused on disease quality,rational diagnosis and treatment,operational management,medical technological value,and policy orientation,and they have significantly optimized service ability and performance evaluation indexes of the hospital.Main achievements included a reduction in the cost consumption index and an increase in the clinical performance index,with the overall DIP payment rate increasing from 88.86%to 103.23%and a marked improvement in operational management.The quality control and operational efficiency of the hospital have been effectively enhanced by choosing proper DIP payment evaluation indexes and improving performance management,and provided strong support for the high-quality development of the hospital.

Naval hospitals,the backbone of naval health service system,are the key to build a world-class naval health service system.On the basis of the requirements of military transformation and high-quality development of public hospitals,this paper summarized five aspects of high-quality development of naval hospitals,including directions and regulations,support and contribution of combats,efficiency,sustainable development momentum,and the expansion of service functions.It is very important to strengthen the top-level design and policy support for naval hospitals,to improve the level of governance and innovation,and to find the right target for the naval hospital construction in naval health service system reform.

Objective To analyze the efficacy of higher pressure recompression therapy (≥70 m) in the patients with decompression sickness (DCS),who displayed poor efficacy after initial recompression.Methods Forty patients with type Ⅱ DCS who received treatment in our hospital from September 2011 to June 2018 were selected as research subjects,and were designated as the study group (n =6) and the control group (n =34),in accordance with whether or not they had received recompression therapy before admission into hospital.The DCS patients of the study group were those transferred to our hospital after initial lower pressure recompression treatment with unsatisfactory results.These patients were treated with the Air Diving DCS Recompression Treatment Table (Table 5,Oxygen Breathing) developed by the Chinese Naval Medical Research Institute,at a pressure of 70 meters and with a total oxygen breathing time of 225 minutes.The patients of the control group were those with type Ⅱ DCS patients who received initial recompression treatment in our hospital within the same time span.Delayed time,application rate and treatment efficacy in the patients of the 2 groups were analyzed statistically.Results The delayed time (14.5 ± 4.9 h) of the secondary recompression group (or the study group) was obviously longer than that of the control group(4.3 ± 3.0 h) (P ＜ 0.001),and there was statistical significance when comparisons were made between them (P ＜ 0.001).The application rate of higher pressure treatment profile in the secondary recompression group (83.3％) was higher than that of the control group (5.9％),also with statistical significance (P ＜ 0.001).The treatment efficacy of the 2 group was identical,without statistical significance (P =0.585).Conclusion The higher pressure recompression profile could effectively treat those DCS patients who showed unsatisfactory treatment effects after initial recompression.For those DCS patients with delayed treatment,proper recompression profile could also achieve satisfactory treatment outcome.With the lack of low pressure oxygen-breathing treatment profile and other supplementary treatment methods,secondary higher pressure recompression treatment should be performed as early possible,in the treatment of the patients with type Ⅱ DCS.

Objective To construct an operational effectiveness evaluation system for submarine rescue medical team,so as to objectively evaluate its operational effectiveness.Methods AHP method combined with the Delphi method was used to determine the operational effectiveness evaluation index and weight of the submarine rescue medical team.Results The evaluation index system consisting of 3 first-class indexes and 11 second-class indexes was constructed.In the first-class indexes,the weight of the organizing and commanding ability,the weight of support ability of the medical system and the weight of the maritime medical treatment ability were respectively 0.121,0.293 and 0.586.Conclusion The construction of the operational effectiveness evaluation system for the submarine rescue medical team by AHP method was scientifically sound and practical,and the maritime medical rescue ability was the core of the operational ability of the submarine rescue medical team.

Objective To analyze the efficacy of higher pressure recompression therapy (≥70 m) in the patients with decompression sickness (DCS),who displayed poor efficacy after initial recompression.Methods Forty patients with type Ⅱ DCS who received treatment in our hospital from September 2011 to June 2018 were selected as research subjects,and were designated as the study group (n =6) and the control group (n =34),in accordance with whether or not they had received recompression therapy before admission into hospital.The DCS patients of the study group were those transferred to our hospital after initial lower pressure recompression treatment with unsatisfactory results.These patients were treated with the Air Diving DCS Recompression Treatment Table (Table 5,Oxygen Breathing) developed by the Chinese Naval Medical Research Institute,at a pressure of 70 meters and with a total oxygen breathing time of 225 minutes.The patients of the control group were those with type Ⅱ DCS patients who received initial recompression treatment in our hospital within the same time span.Delayed time,application rate and treatment efficacy in the patients of the 2 groups were analyzed statistically.Results The delayed time (14.5 ± 4.9 h) of the secondary recompression group (or the study group) was obviously longer than that of the control group(4.3 ± 3.0 h) (P ＜ 0.001),and there was statistical significance when comparisons were made between them (P ＜ 0.001).The application rate of higher pressure treatment profile in the secondary recompression group (83.3％) was higher than that of the control group (5.9％),also with statistical significance (P ＜ 0.001).The treatment efficacy of the 2 group was identical,without statistical significance (P =0.585).Conclusion The higher pressure recompression profile could effectively treat those DCS patients who showed unsatisfactory treatment effects after initial recompression.For those DCS patients with delayed treatment,proper recompression profile could also achieve satisfactory treatment outcome.With the lack of low pressure oxygen-breathing treatment profile and other supplementary treatment methods,secondary higher pressure recompression treatment should be performed as early possible,in the treatment of the patients with type Ⅱ DCS.

Objective To construct an operational effectiveness evaluation system for submarine rescue medical team,so as to objectively evaluate its operational effectiveness.Methods AHP method combined with the Delphi method was used to determine the operational effectiveness evaluation index and weight of the submarine rescue medical team.Results The evaluation index system consisting of 3 first-class indexes and 11 second-class indexes was constructed.In the first-class indexes,the weight of the organizing and commanding ability,the weight of support ability of the medical system and the weight of the maritime medical treatment ability were respectively 0.121,0.293 and 0.586.Conclusion The construction of the operational effectiveness evaluation system for the submarine rescue medical team by AHP method was scientifically sound and practical,and the maritime medical rescue ability was the core of the operational ability of the submarine rescue medical team.

To develop a portable medicine coffer for medical support in order to standardize the management of special medicine. The coffer with double-fingerprint cryptography and internal mechanical lock was com-posed of a body and a cap. The coffer had the body made of high-intensity plastics or light alloy, monitor made of high-intensity abrasion-resistant glass as well as rechargeable lithium battery. The coffer eliminated the deficiencies of traditional medicine chest. The portable coffer standardizes the management of special medicine for medical support.

Objective To investigate the training and requirements of first aid skills among medical officers onboard naval vessels .Methods An investigation was made on the first aid skills of 56 naval afloat medical officers from a certain naval detachment , who took part in the first aid training , and a statistical analysis was made accordingly .Results A total of 56 effective questionnaires were recovered .Analysis revealed that the medical officers onboard the naval vessels were lacking in the skills of cardiopulmonary resus -citation, the establishment of venous access , invasive diagnosis and treatment techniques , the application of first aid , etc.Conclusion Most naval afloat medical officers were insufficient in the training of comprehensive first aid skills , and they had urgent demands for further training on first aid skills .

Objective To identify the medical qualities and requirements for standardized training of medical officers in basic naval units , so as to provide evidence for the implementation of targeted standardized medical training in basic naval units .Methods Medical officers in the basic units of a certain fleet were chosen as research subjects and a questionnaire survey was conducted accord -ingly .The results obtained were analyzed statistically by using the statistical software .Results The scores of insufficiency for "medical manipulating skills"were the highest , comprehensive scores of work ability , work performance and work environment were moderate (7.97 ±1.55).The daily workload of medical officers in naval basic units was relatively lower and the diseases they commonly en -countered were upper respiratory tract infection , trauma, training injury and dermatosis , etc.The skills for the diagnosis and treatment of cardiovascular-cerebrovascular diseases , infectious diseases , gastrointestinal diseases , as well as manipulating skills of medical e-quipment demanded further improvement .71.13%of medical officers were in the opinion that it was absolutely necessary for them to receive standardized training , with a training duration of one year as the most desirable .Training focuses should be directed at the fol-lowing:the training of clinical analysis and solution of medical problems (80.06%), the training of basic skills and manipulating skills (67.56%) and extension of comprehensive knowledge (56.55%).Conclusion The professional qualities of navy medical officers were relatively weak, for this reason, there was an urgent requirement for them to have standardized medical training .It was recommen-ded that the mechanism of training , employment and management be developed in accordance with the practical conditions of basic u -nits, the time for training be properly arranged , standardized training subjects be optimized , and most importantly , the system for the training of medical officers in basic naval units be perfected step by step , so as to promote medical support capability of front-line units.