As a new manner of cell death,cuproptosis depends on the accumulation of copper ions in cells.Copper ion is an essential trace element in normal physiological state of organisms.The excess of free copper in cells not only has toxic effect on normal cells,but also plays its specific killing function on tumor cells.Copper transporter 1(CTR1)is a key transporter of transmembrane uptake of copper ions by cells.As a regulator of cuproptosis,its mutation and expression changes in tumors have an impact on the distribution of copper ions inside and outside the cells.It may participate in multiple biological processes such as proliferation,invasion and migration of tumor cells by regulating the pathway of cuproptosis.This article reviews the cuproptosis pathway mediated by CTR1 and the potential value of CTR1 in tumor treatment,elaborates the importance of copper ion homeostasis regulation for normal life activities and the mechanism of CTR1 in regulating cuproptosis,and discusses the potential value of CTR1 as a new target for tumor therapy,so as to provide a theoretical basis for the treatment of tumor patients.

In the context of medical insurance payment reform,the sample hospital has implemented performance management optimization to effectively address the challenges posed by diagnosis-intervention packet(DIP)payment.Reform measures focused on disease quality,rational diagnosis and treatment,operational management,medical technological value,and policy orientation,and they have significantly optimized service ability and performance evaluation indexes of the hospital.Main achievements included a reduction in the cost consumption index and an increase in the clinical performance index,with the overall DIP payment rate increasing from 88.86%to 103.23%and a marked improvement in operational management.The quality control and operational efficiency of the hospital have been effectively enhanced by choosing proper DIP payment evaluation indexes and improving performance management,and provided strong support for the high-quality development of the hospital.

Naval hospitals,the backbone of naval health service system,are the key to build a world-class naval health service system.On the basis of the requirements of military transformation and high-quality development of public hospitals,this paper summarized five aspects of high-quality development of naval hospitals,including directions and regulations,support and contribution of combats,efficiency,sustainable development momentum,and the expansion of service functions.It is very important to strengthen the top-level design and policy support for naval hospitals,to improve the level of governance and innovation,and to find the right target for the naval hospital construction in naval health service system reform.

To develop a portable medicine coffer for medical support in order to standardize the management of special medicine. The coffer with double-fingerprint cryptography and internal mechanical lock was com-posed of a body and a cap. The coffer had the body made of high-intensity plastics or light alloy, monitor made of high-intensity abrasion-resistant glass as well as rechargeable lithium battery. The coffer eliminated the deficiencies of traditional medicine chest. The portable coffer standardizes the management of special medicine for medical support.

Objective To investigate the training and requirements of first aid skills among medical officers onboard naval vessels .Methods An investigation was made on the first aid skills of 56 naval afloat medical officers from a certain naval detachment , who took part in the first aid training , and a statistical analysis was made accordingly .Results A total of 56 effective questionnaires were recovered .Analysis revealed that the medical officers onboard the naval vessels were lacking in the skills of cardiopulmonary resus -citation, the establishment of venous access , invasive diagnosis and treatment techniques , the application of first aid , etc.Conclusion Most naval afloat medical officers were insufficient in the training of comprehensive first aid skills , and they had urgent demands for further training on first aid skills .

Objective To identify the medical qualities and requirements for standardized training of medical officers in basic naval units , so as to provide evidence for the implementation of targeted standardized medical training in basic naval units .Methods Medical officers in the basic units of a certain fleet were chosen as research subjects and a questionnaire survey was conducted accord -ingly .The results obtained were analyzed statistically by using the statistical software .Results The scores of insufficiency for "medical manipulating skills"were the highest , comprehensive scores of work ability , work performance and work environment were moderate (7.97 ±1.55).The daily workload of medical officers in naval basic units was relatively lower and the diseases they commonly en -countered were upper respiratory tract infection , trauma, training injury and dermatosis , etc.The skills for the diagnosis and treatment of cardiovascular-cerebrovascular diseases , infectious diseases , gastrointestinal diseases , as well as manipulating skills of medical e-quipment demanded further improvement .71.13%of medical officers were in the opinion that it was absolutely necessary for them to receive standardized training , with a training duration of one year as the most desirable .Training focuses should be directed at the fol-lowing:the training of clinical analysis and solution of medical problems (80.06%), the training of basic skills and manipulating skills (67.56%) and extension of comprehensive knowledge (56.55%).Conclusion The professional qualities of navy medical officers were relatively weak, for this reason, there was an urgent requirement for them to have standardized medical training .It was recommen-ded that the mechanism of training , employment and management be developed in accordance with the practical conditions of basic u -nits, the time for training be properly arranged , standardized training subjects be optimized , and most importantly , the system for the training of medical officers in basic naval units be perfected step by step , so as to promote medical support capability of front-line units.

Objective To investigate the training requirements of military civilian nursing backbones in scientific nursing re-search.Methods A questionnaire survey was conducted among the 93 military civilian personnel taking part in the 8t h working-post training class of military civilian nursing backbones by using the questionnaire specifically developed for the study.Results Ninety per cent of the military civilian nursing backbones held that it was absolutely necessary to conduct training on scientific nursing research. The top 3 training requirements for scientific nursing research were:scientific nursing research design (accounting for 89%),medical statistics (accounting for 83%)and thesis writing skill (accounting for 80%).The top 3 requirements of training forms were:scientific research training courses (accounting for 85%),seminars (accounting for 82%)and expert instruction (accounting for 71%).A 2 to 4-week training period was most appropriate for scientific research training.Conclusion Attention should be paid on the part of the nursing administration to the selection of appropriate scientific research training programs and training methods,as well as flexible ar-rangement of training time,so as to improve scientific research capacity of the military civilian nursing backbones.

Objective:To reveal the behavior characteristics of health delivery system(HDS) and the dynamical mechanism by which HDS promoting population health,so as to provide theoretical and methodological evidences for the decision-making of national macro health system.Methods: The macro model of HDS was constructed by using the theory of complex system and the method of system dynamics.Results: The principle of "high coverage and reasonable quality" was put forward as developmental strategy of national health service.The improvement of population health was taken as the system objective of HDS;meanwhile,HDS was community-centered and city-country integrative.The macro model of HDS was constructed based on the above objectives.Conclusion: Modeling based on system dynamics is effective to reveal the complexity of health delivery system.The HDS complex system model constructed in this article can be used to analyze and interpret the behavior characteristics of HDS and the dynamic mechanism by which HDS promoting population health.