Objective To investigate the predictive value of serum complement C1q tumor necrosis factor-related protein 3(CTRP3)and chitinase protein-40(YKL-40)in the prognosis of implants in patients with dentition defect after implant restoration.Methods A total of 98 patients with dentition defect were selected as the observation group,and 98 healthy people were selected as the control group.Based on the prognosis of the implant,patients were assigned into the good prognosis group(67 cases)and the poor prognosis group(31 cases).Enzyme linked immunosorbent assay was applied to detect serum levels of CTRP3 and YKL-40.Multivariate Logistic regression analysis was performed to analyze factors influencing the prognosis of implant defects.The receiver operating characteristic(ROC)curve was used to evaluate the efficacy of serum CTRP3 and YKL-40 levels in predicting implant prognosis.Results Compared with the control group,the serum CTRP3 level was prominently lower in the study group,and the serum YKL-40 level was prominently higher(P＜0.05).Compared with the good prognosis group,the proportion of smoking patients and the serum YKL-40 level were prominently higher in the poor prognosis group,and the serum CTRP3 level was prominently lower(P＜0.05).Elevated serum YKL-40 level and smoking history were risk factors for poor implant prognosis in patients,while elevated serum CTRP3 level was the protective factor(P＜0.05).ROC curve analysis showed that the combination of serum CTRP3 and YKL-40 levels was superior to any single indicator in predicting the poor prognosis of implants in patients with dentition defect.Conclusion Serum CTRP3 level is decreased and serum YKL-40 level is increased in patients with dental defect,both of which are potential factors affecting poor implant prognosis.The combination of the two is more effective in predicting implant prognosis in patients with dental defect.

Objective To investigate the predictive value of serum complement C1q tumor necrosis factor-related protein 3(CTRP3)and chitinase protein-40(YKL-40)in the prognosis of implants in patients with dentition defect after implant restoration.Methods A total of 98 patients with dentition defect were selected as the observation group,and 98 healthy people were selected as the control group.Based on the prognosis of the implant,patients were assigned into the good prognosis group(67 cases)and the poor prognosis group(31 cases).Enzyme linked immunosorbent assay was applied to detect serum levels of CTRP3 and YKL-40.Multivariate Logistic regression analysis was performed to analyze factors influencing the prognosis of implant defects.The receiver operating characteristic(ROC)curve was used to evaluate the efficacy of serum CTRP3 and YKL-40 levels in predicting implant prognosis.Results Compared with the control group,the serum CTRP3 level was prominently lower in the study group,and the serum YKL-40 level was prominently higher(P＜0.05).Compared with the good prognosis group,the proportion of smoking patients and the serum YKL-40 level were prominently higher in the poor prognosis group,and the serum CTRP3 level was prominently lower(P＜0.05).Elevated serum YKL-40 level and smoking history were risk factors for poor implant prognosis in patients,while elevated serum CTRP3 level was the protective factor(P＜0.05).ROC curve analysis showed that the combination of serum CTRP3 and YKL-40 levels was superior to any single indicator in predicting the poor prognosis of implants in patients with dentition defect.Conclusion Serum CTRP3 level is decreased and serum YKL-40 level is increased in patients with dental defect,both of which are potential factors affecting poor implant prognosis.The combination of the two is more effective in predicting implant prognosis in patients with dental defect.

Terpine-4-ol is abundant in nature. As a cyclic monoterpenoid compound， terpine-4-ol is distributed in a variety of natural plants. It is the main component and the key active substance in many traditional Chinese essential oils， such as Melaleuca alba essential oil and coral ginger essential oil. Terpine-4-ol has anti-microbial， anti-tumor， insecticidal， anti-inflammatory， and other effects. It can treat cancer， as well as oral and cardiovascular diseases with great safety. In terms of antibacterial activity， terpine-4-ol can destroy bacterial cell walls， improve membrane permeability， and regulate bacterial migration， reproduction， and other related genes to inhibit bacterial activity. In terms of antifungal activity， terpine-4-ol can bind with ergosterol in fungal cell walls to cause fungal death. In terms of insecticidal activity， terpine-4-ol can inhibit Na⁺ and K⁺-ATPase activity and cause the death of the insect. In terms of anticancer activity， terpine-4-ol can regulate the expression of apoptosis-related proteins in cancer cells， so as to control the apoptosis of cancer cells. In this paper， the pharmacological activity and action mechanism of terpine-4-ol were reviewed to provide a reference for further research and utilization of terpine-4-ol.