1.Recent Advances in the Treatment of Inflammatory Peripheral Neuropathy
Choi KALAM ; Jinyi YAN ; Peicai FU
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2025;54(5):726-733
Inflammatory peripheral neuropathy,also known as immune-mediated peripheral neuropathy,is a rare group of heterogeneous peripheral neuropathy characterized by dysfunction and damage to different structures of the peripheral nerves,including Guillain-Barre syndrome,chronic demyelinating inflammatory polyradiculopathy,autoimmune neuropathy,multifocal motor neuropathy or neuropathy related to monoclonal gamma globulinopathy,etc.The causes of these diseases remain unclear,but B cells and autoantibodies play a key role in their pathogenesis.This group of diseases can be classified as having acute or chronic onset based on the mode of onset.Clinically,it can present as a unipolar course,recurrent or progressive course.Severe inflammatory peripheral neuropathy can lead to flaccid paralysis of the limbs,with a high risk of severe disability and death.With the rapid progress of various studies in the field of neuroimmunological diseases in recent years,the therapeutic tar-gets/methods for immune-mediated peripheral neuropathy have also presented a flourishing situation.The latest progress at home and abroad is summarized as follows.
2.Recent Advances in the Treatment of Inflammatory Peripheral Neuropathy
Choi KALAM ; Jinyi YAN ; Peicai FU
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2025;54(5):726-733
Inflammatory peripheral neuropathy,also known as immune-mediated peripheral neuropathy,is a rare group of heterogeneous peripheral neuropathy characterized by dysfunction and damage to different structures of the peripheral nerves,including Guillain-Barre syndrome,chronic demyelinating inflammatory polyradiculopathy,autoimmune neuropathy,multifocal motor neuropathy or neuropathy related to monoclonal gamma globulinopathy,etc.The causes of these diseases remain unclear,but B cells and autoantibodies play a key role in their pathogenesis.This group of diseases can be classified as having acute or chronic onset based on the mode of onset.Clinically,it can present as a unipolar course,recurrent or progressive course.Severe inflammatory peripheral neuropathy can lead to flaccid paralysis of the limbs,with a high risk of severe disability and death.With the rapid progress of various studies in the field of neuroimmunological diseases in recent years,the therapeutic tar-gets/methods for immune-mediated peripheral neuropathy have also presented a flourishing situation.The latest progress at home and abroad is summarized as follows.
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