Objective:To investigate the effects of risperidone combined with metformin on homocysteine levels and glycolipid metabolism in patients with schizophrenia.Methods:A randomized controlled study was conducted involving 124 patients with schizophrenia who received treatment at Quzhou Third Hospital from January 2022 to June 2023. The patients were divided into a study group and a control group, with 62 patients in each group, based on a random number table. The study group was treated with risperidone combined with metformin, while the control group received risperidone treatment along with a placebo of the same dose as metformin. The treatment duration for both groups was 3 months. Clinical efficacy was evaluated, and changes in homocysteine levels and glycolipid metabolism were measured before and after treatment.Results:The difference in overall efficacy between the two groups was not statistically significant ( P = 0.697). After treatment, the homocysteine levels in the study group [(15.26 ± 2.11) μmol/L] were significantly lower than those in the control group [(19.01 ± 2.04) μmol/L, t = 9.87, P < 0.001]. The fasting blood glucose [(6.15 ± 0.57) mmol/L], 2-hour postprandial blood glucose [(12.41 ± 2.67) mmol/L], fasting insulin [(24.23 ± 3.21) μIU/mL], and total cholesterol [(6.04 ± 1.39) mmol/L] in the study group were all higher than those in the control group [(4.93 ± 0.45) mmol/L, (10.68 ± 2.46) mmol/L, (22.93 ± 3.05) μIU/mL, (0.91 ± 0.12) mmol/L, t = -13.23, -3.75, -2.31, -6.24, all P < 0.05]. The waist-to-hip ratio in the study group was (0.81 ± 0.09), which was significantly lower than that in the control group [(0.91 ± 0.12), t = 5.25, P < 0.001]. There was no significant difference in incidence of adverse reactions between the two groups ( P = 0.081). Conclusions:The combination of risperidone and metformin in the treatment of schizophrenia is beneficial for decreasing patients' homocysteine levels, preventing abnormalities in glycolipid metabolism, and reducing waist-to-hip ratios. This treatment demonstrates good efficacy and safety.

Objective:To investigate the factors associated with prolonged QTc interval in long-term hospitalized patients with schizophrenia, and to develop and validate a predictive model.Methods:A cross-sectional study was conducted involving 215 long-term hospitalized patients with schizophrenia at Xianyang Hospital, Yan'an University from January to December 2023. The incidence of prolonged QTc intervals among the patients was analyzed. Univariate and multivariate analyses of the factors associated with prolonged QTc intervals were performed. A mathematical model was developed to predict prolonged QTc intervals in long-term hospitalized patients with schizophrenia, and the predictive performance of the model was evaluated.Results:Among the 215 patients, 42 exhibited prolonged QTc intervals, with an incidence rate of 19.53%. Univariate analysis revealed statistically significant differences between the groups with and without prolonged QTc in terms of age, gender, body mass index, categories of antipsychotic medication used, fasting blood glucose, and potassium levels ( t = -5.66, χ2 = 29.03, t = -2.01, χ2 = 10.96, t = -5.78, t = 5.92, all P < 0.05). Multivariate logistic regression analysis indicated that age, gender, fasting blood glucose, and potassium levels were independent factors affecting QTc interval prolongation ( OR = 1.097, 10.221, 2.449, 0.014, all P < 0.05). The goodness-of-fit of the logistic regression model was validated to be satisfactory (Hosmer-Lemeshow χ2 = 14.56, P > 0.05). A risk nomogram model based on the variables from the multivariate analysis had a C-index of 0.713. Receiver operating characteristic curve analysis was performed using the independent influential factors and their P values from the logistic regression model to predict the probability of QTc interval prolongation. The area under the curve values were 0.762, 0.725, 0.730, 0.792, and 0.920, respectively. Conclusions:The incidence of prolonged QTc interval is relatively high in long-term hospitalized patients with schizophrenia. Female gender, older age, hyperglycemia, and hypokalemia are all associated with prolonged QTc intervals. The mathematical model developed based on these factors demonstrates good predictive performance for QTc interval prolongation.

Objective:To explore the clinical efficacy of cognitive therapy combined with transcranial direct current stimulation in the treatment of schizophrenia.Methods:A randomized controlled study was conducted involving 118 patients with schizophrenia treated at The Second People's Hospital of Lishui from January 2021 to January 2023. The participants were divided into a control group and an observation group, with 59 patients in each group using a random number table method. The control group received cognitive therapy, while the observation group received cognitive therapy combined with transcranial direct current stimulation. Both groups underwent treatment for 8 weeks. Clinical symptom scores, treatment compliance, and the scores of Excited Component of the Positive and Negative Syndrome Scale, the Berkeley Expressivity Questionnaire, the Insight and Treatment Attitudes Questionnaire, and the Social Behavior Scale were compared between the two groups.Results:After intervention, the scores for activation, cognitive impairment, paranoia, depression, and aggression on the clinical symptom rating scale in the observation group were significantly lower than those in the control group ( t = 8.45, 6.68, 4.60, 6.92, 5.59, all P < 0.001). The overall compliance rate in the observation group was significantly higher than that in the control group [89.8% (53/59) vs. 74.6% (44/59), χ2 = 4.69, P < 0.05]. The score of Excited Component of the Positive and Negative Syndrome Scale in the observation group was significantly lower than that in the control group [(7.92 ± 1.75) vs. (9.35 ± 1.89), t = 4.26, P < 0.001]. The score of the Berkeley Expressivity Questionnaire in the observation group was significantly higher than that in the control group [(61.23 ± 5.79) vs. (55.38 ± 6.05), t = 5.37, P < 0.001]. The score of Insight and Treatment Attitudes Questionnaire in the observation group was significantly higher than that in the control group [(18.74 ± 3.69) vs. (12.41 ± 2.25), t = 11.25, P < 0.001]. The score of the Social Behavior Scale in the observation group was significantly lower than that in the control group [(15.23 ± 3.76) vs. (18.09 ± 4.28), t = 3.86, P < 0.001]. Conclusions:Cognitive therapy combined with transcranial direct current stimulation has shown significant effects in treating patients with schizophrenia. This combination therapy effectively improves treatment compliance and emotional expression abilities, alleviates symptoms of agitation, and enhances cognitive function and social skills in patients.

Objective:To investigate the efficacy of high-flux hemodialysis combined with hemoperfusion in patients with uremia.Methods:Eighty patients with uremia who received treatment at the Quzhou Hospital Affiliated to Wenzhou Medical University (Quzhou People's Hospital) from January 2020 to December 2022 were selected for this prospective randomized controlled trial. Participants were grouped using a random number table method, with 40 patients in the study group receiving high-flux hemodialysis combined with hemoperfusion, and 40 patients in the control group receiving high-flux hemodialysis alone. Toxicity clearance, calcium-phosphate metabolism, immune function, and vascular endothelial function were assessed using competitive enzyme-linked immunosorbent assay, immunofluorescence assay, fully automated biochemical analyzers, and immunoturbidimetric assay. The differences in toxicity clearance, calcium-phosphate metabolism, immune function, and vascular endothelial function were compared between the two groups.Results:Compared with before treatment, both groups showed a significant decrease in parathyroid hormone (PTH), blood creatinine, β 2-microglobulin, blood urea nitrogen, blood phosphorus, advanced glycation end products (AGEs), intercellular adhesion molecule-1 (ICAM-1), and homocysteine (Hcy) after treatment. Specifically, PTH levels decreased from (353.28 ± 50.26) ng/L to (235.26 ± 31.51) ng/L in the control group and from (357.17 ± 52.18) ng/L to (174.16 ± 26.35) ng/L in the study group; blood creatinine decreased from (969.47 ± 110.44) μmol/L to (511.57 ± 91.96) μmol/L in the control group and from (957.58 ± 121.99) μmol/L to (414.37 ± 87.41) μmol/L in the study group; β 2-microglobulin decreased from (40.27 ± 7.98) mg/L to (22.06 ± 3.26) mg/L in the control group and from (41.65 ± 8.40) mg/L to (17.70 ± 3.43) mg/L in the study group; blood urea nitrogen decreased from (30.64 ± 5.63) mmol/L to (14.02 ± 2.80) mmol/L in the control group and from (30.04 ± 5.90) mmol/L to (10.07 ± 1.94) mmol/L in the study group; blood phosphorus decreased from (2.23 ± 0.49) mmol/L to (1.80 ± 0.36) mmol/L in the control group and from (2.26 ± 0.53) mmol/L to (1.53 ± 0.31) mmol/L in the study group ; Hcy decreased from (35.87 ± 5.34) μmol/L to (30.93 ± 4.65) μmol/L in the control group and from (36.21 ± 5.27) μmol/L to (20.26 ± 4.53) μmol/L in the study group; ICAM-1 decreased from (574.96 ± 56.81) ng/L to (419.87 ± 40.76) ng/L in the control group and from (569.84 ± 52.37) ng/L to (384.51 ± 35.12) ng/L in the study group; AGEs levels decreased from (330.41 ± 43.69) mg/L to (297.64 ± 38.59) mg/L in the control group and from (326.98 ± 41.25) mg/L to (165.42 ± 15.74) mg/L in the study group. Conversely, compared with before treatment,blood calcium, immunoglobulin G, immunoglobulin M, immunoglobulin A, CD 4+, CD 4+/CD 8+ ratio, complement 3, and complement 4 all increased after treatment. Specifically, blood calcium increased from (1.90 ± 0.43) mmol/L to (2.27 ± 0.32) mmol/L in the control group and from (1.93 ± 0.46) mmol/L to (2.61 ± 0.36) mmol/L in the study group; IgG increased from (7.73 ± 1.56) g/L to (9.21 ± 2.04) g/L in the control group and from (7.82 ± 1.62) g/L to (10.7 ± 2.02) g/L in the study group; IgM increased from (0.42 ± 0.07) g/L to (1.29 ± 0.11) g/L in the control group and from (0.40 ± 0.08) g/L to (1.52 ± 0.08) g/L in the study group; IgA increased from (0.44 ± 0.16) g/L to (1.54 ± 0.25) g/L in the control group and from (0.48 ± 0.19) g/L to (1.93 ± 0.38) g/L in the study group; CD 4+ increased from (32.77 ± 5.71)% to (38.18 ± 4.92)% in the control group and from (32.11 ± 5.34)% to (46.07 ± 4.95)% in the study group; the CD 4+/CD 8+ ratio increased from (1.07 ± 0.14) to (1.29 ± 0.15) in the control group and from (1.07 ± 0.17) to (1.61 ± 0.26) in the study group; C3 increased from (0.80 ± 0.12) g/L to (1.01 ± 0.20) g/L in the control group and from (0.79 ± 0.14) g/L to (1.19 ± 0.23) g/L in the study group; and C4 increased from (0.32 ± 0.15) g/L to (0.67 ± 0.17) g/L in the control group and from (0.33 ± 0.14) g/L to (0.86 ± 0.12) g/L in the study group. All these differences were statistically significant between the two groups ( t = 12.01, 19.47, 33.98, 33.72, 17.64, 20.36, 22.75, 24.28, 19.25, 22.77, 4.71, 29.54, 32.01, 27.39, -5.06, -11.39, -4.79, -9.65, -61.55, -97.13, -36.63, -32.21, -7.71, -16.90, -5.78, -11.34, -9.21, -13.28, -13.25, -33.73, all P < 0.05). Additionally, when compared with the control group, the study group showed superior results ( t = -9.40, -4.84, -5.82, -7.33, -3.59, -10.40, -4.16, -20.07, 4.47, 3.28, 5.43, 7.14, 6.73, 3.73, 5.76, all P < 0.05). Conclusions:High-flux hemodialysis combined with hemoperfusion for the treatment of uremia can effectively improve calcium and phosphorus metabolism and vascular endothelial function, as well as enhance immune function and toxicity clearance rate.

Objective:To investigate the prevalence of infectious diarrhea among older adult patients with schizophrenia, identify the influential factors, and construct a nomogram prediction model for infectious diarrhea.Methods:This study is a prospective cohort study that used convenience sampling to select 160 older patients with schizophrenia from three psychiatric hospitals in Wenzhou (85 cases from Wenzhou Seventh People's Hospital, 40 cases from Lucheng Third People's Hospital, and 35 cases from The Affiliated Kangning Hospital of Wenzhou Medical University) who were admitted between January 2022 and December 2023. The prevalence of infectious diarrhea and its influential factors were statistically analyzed. Regression analysis was conducted to develop a risk prediction model for infectious diarrhea, which was presented using a nomogram.Results:A total of 160 older adult patients with schizophrenia were aged between 61 and 79 years, with an average age of (67.82 ± 7.56) years. Among these patients, 53 were female (33.13%), and 107 were male (66.87%). Thirty-four patients experienced infectious diarrhea, with an incidence rate of 21.25%. Univariate analysis revealed significant differences in body mass index ( χ2 = 9.36, P = 0.009), history of diarrhea ( χ2 = 4.52, P = 0.033), disinfection of tableware ( χ2 = 4.16, P = 0.04), handwashing before and after meals ( χ2 = 6.11, P = 0.013), intestinal flora disorder ( χ2 = 19.43, P < 0.001), CD 4+/CD 8+ ratio ( t = 12.37, P < 0.001), interleukin-17 ( t = 15.86, P < 0.001), and fecal secretory IgA ( t = 20.18, P < 0.001) in older adult patients with schizophrenia. Multifactorial analysis indicated that body mass index ( OR = 0.733), disinfection of tableware ( OR = 0.733), handwashing before and after meals ( OR = 0.452), CD 4+/CD 8+ ratio ( OR = 0.359), interleukin-17 ( OR = 0.563), and fecal secretory IgA ( OR = 0.455) were protective factors against infectious diarrhea in older adult patients with schizophrenia (all P < 0.05). Conversely, a history of diarrhea ( OR = 1.774) and intestinal flora disorder ( OR = 1.528) were identified as risk factors for infectious diarrhea in this population (both P < 0.05). Conclusions:The influential factors for the occurrence of infectious diarrhea in older adult patients with schizophrenia include body mass index, history of diarrhea, disinfection of tableware, handwashing before and after meals, intestinal flora disorder, CD 4+/CD 8+ ratio, interleukin-17, and fecal secretory IgA levels. Future studies should conduct longitudinal research to optimize the prediction model and establish a dynamic nomogram model. This will provide nurses with a reliable tool for dynamically predicting the occurrence of infectious diarrhea in older adult patients with schizophrenia, with the aim of reducing the incidence of infectious diarrhea and improving the patients' quality of life.

Objective:To investigate the clinical efficacy of Jiuwei Zhenxin Granules combined with lithium carbonate in improving sleep quality in patients with insomnia during the remission phase of bipolar disorder. Methods:A total of 140 patients with insomnia during the remission phase of bipolar disorder, admitted to Jinhua Maternal and Child Health Care Hospital from March 2021 to March 2024, were selected for this study. This study used a retrospective research method. These patients were divided into a control group ( n = 70) and an observation group ( n = 70) according to the different treatment approaches. The control group received lithium carbonate sustained-release tablets, while the observation group received Jiuwei Zhenxin Granules in addition to the lithium carbonate treatment. The efficacy of the treatments for insomnia during the remission phase of bipolar disorder, as well as sleep quality and psychological status, was assessed. Polysomnography indicators of sleep quality were monitored. Serum levels of sleep-related neurotransmitters were measured. Adverse drug reactions were statistically analyzed. Results:In the observation group, the overall treatment efficacy for insomnia during the remission phase of bipolar disorder was significantly higher at 91.43% (64/70) compared with the control group at 71.43% (50/70) ( Z = 5.00, P < 0.001). After 4 weeks of treatment, the Pittsburgh Sleep Quality Index score, the Bech-Rafaelsen Mania Scale score, the Self-Rating Depression Scale score, and the Self-Rating Anxiety Scale score in the observation group were (7.62 ± 1.83), (22.07 ± 2.42), (26.35 ± 2.79), and (24.68 ± 2.65), respectively, which were significantly lower than those in the control group [(11.57 ± 2.14), (29.45 ± 3.11), (33.42 ± 3.81), (35.17 ± 3.92), t = 10.52, 12.84, 14.25, 17.34, all P < 0.001]. Within 4 weeks after treatment, the total sleep duration in the observation group was longer than that in the control group [(8.09 ± 1.17) hours vs. (6.37 ± 0.96) hours, P < 0.001], while the sleep latency in the observation group was shorter than that in the control group [(20.71 ± 2.28) minutes vs. (24.39 ± 2.62) minutes, P < 0.001]. Additionally, the number of awakenings was fewer in the observation group than that in the control group [(2.36 ± 0.37) times vs. (3.51 ± 0.42) times, P < 0.001]. After 4 weeks of treatment, the levels of sleep-related neurotransmitters serum serotonin, melatonin, β-endorphin, and γ-aminobutyric acid in the observation group were (0.51 ± 0.12) μg/L, (29.65 ± 3.27) ng/L, (18.49 ± 1.92) μg/L, and (287.45 ± 15.60) μg/L, respectively. These values were significantly higher than those in the control group [(0.43 ± 0.10) μg/L, (22.41 ± 2.54) ng/L, (14.05 ± 1.73) μg/L, and (239.06 ± 12.73) μg/L, t = -6.62, -13.43, -11.67, -18.52, all P < 0.001]. There was no significant difference in the incidence of adverse drug reactions between the observation and control groups [8.57% (6/70) vs. 11.43% (8/70), χ2 = 0.31, P = 0.573]. Conclusions:The combination of Jiuwei Zhenxin Granules and lithium carbonate can improve sleep quality, alleviate insomnia-related symptoms, and enhance overall prognosis in patients with insomnia during the remission phase of bipolar disorder by regulating neuroendocrine function.

Objective:To investigate the correlation between coronary heart disease and hemoglobin levels in high-altitude regions, China.Methods:This study is a single-center retrospective study involving 298 patients who were hospitalized and underwent coronary angiography at the People's Hospital of Xizang Autonomous Region from January to December 2022. The patients were divided into a lesion group and a control group based on the presence of coronary artery lesions. Among them, 152 patients were diagnosed with coronary heart disease and were assigned to the lesion group, while 146 patients had normal coronary angiography results and were included in the control group. Hemoglobin levels, age, systolic blood pressure, diastolic blood pressure, and other relevant data were compared between the two groups. Furthermore, based on the status of the coronary artery lesions, the patients were categorized into single-vessel lesion, double-vessel lesion, and triple-vessel lesion groups to analyze the correlation between the Gensini score for coronary artery disease and hemoglobin levels in each group.Results:In the control group, hemoglobin, age, D-dimer, fibrinogen degradation products, glycated hemoglobin, C-reactive protein, and fibrinogen were (182.52 ± 28.45) g/L, (59.84 ± 13.14) years, (0.62 ± 1.70) mg/L, (2.92 ± 7.41) mg/L, (6.20 ± 1.22)%, (8.46 ± 21.90) mg/L, and (3.59 ± 1.87) g/L, respectively. In the lesion group, these values were (156.53 ± 23.35) g/L, (56.72 ± 12.70) years, (1.42 ± 2.69) mg/L, (5.32 ± 9.93) mg/L, (6.85 ± 1.88)%, (44.56 ± 64.29) mg/L, and (4.48 ± 2.18) g/L, respectively. The lesion group had lower hemoglobin levels and younger age, while levels of D-dimer, fibrinogen degradation products, glycated hemoglobin, C-reactive protein, and fibrinogen were significantly higher ( t = -5.58, -8.75, -2.59, -2.00, -2.82, -5.29, -3.21, all P < 0.05). A binary logistic regression analysis of these factors revealed that hemoglobin ( OR = 0.35, 95% CI: 0.08-0.78) is a protective factor for coronary heart disease ( P < 0.05). Both D-dimer ( OR = 1.42, 95% CI: 1.00-2.15) and glycated hemoglobin ( OR = 1.30, 95% CI: 1.00-1.60) were identified as independent risk factors for coronary heart disease (both P < 0.05). In the lesion group, hemoglobin levels were highest in the single-vessel lesion group [(161.22 ± 19.28) g/L], followed by the double-vessel lesion group [(154.84 ± 23.66) g/L], and lowest in the triple-vessel lesion group [(144.34 ± 26.57) g/L, all P < 0.05]. The Gensini scores were highest in the triple-vessel lesion group (89.96 ± 33.14), followed by the double-vessel lesion group (59.25 ± 17.28), and lowest in the single-vessel lesion subgroup (8.35 ± 4.56) (all P < 0.05). Conclusions:Hemoglobin is a protective factor for coronary heart disease, with lower hemoglobin levels associated with more severe coronary artery lesions in coronary heart disease.

Objective:To investigate auricular acupressure combined with massage-tapping exercises on body indicators, blood lipids, and liver function in patients with obesity-related fatty liver disease.Methods:This retrospective study included 78 patients with obesity-related fatty liver disease admitted to Hangzhou Hospital of Traditional Chinese Medicine from April to December 2023. The patients were divided into two groups based on different treatment methods: the conventional group (36 patients receiving conventional interventions) and the combined group (36 patients receiving auricular acupressure combined with massage-tapping exercises in addition to conventional interventions). The total response rates, physical indicators (body weight, body mass index), blood lipid levels (triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), and liver function indicators (aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase were recorded and compared between the two groups.Results:The total response rate in the combined group was 94.87% (37/39), which was significantly higher than the 76.92% (30/39) in the conventional group ( χ2 = 5.19, P < 0.05). After intervention, the combined group showed lower body weight [(70.42 ± 8.32) kg vs. (75.84 ± 8.46) kg], lower body mass index [(24.32 ± 1.26) kg/m2 vs. (25.48 ± 1.30) kg/m2], lower triglycerides [(1.62 ± 0.42) mmol/L vs. (2.94 ± 0.78) mmol/L], lower total cholesterol [(5.24 ± 0.54) mmol/L vs. (6.72 ± 0.66) mmol/L], lower low-density lipoprotein cholesterol [(2.14 ± 0.46) mmol/L vs. (2.78 ± 0.50) mmol/L], lower aspartate aminotransferase [(35.32 ± 4.38) U/L vs. (40.16 ± 5.14) U/L], lower alanine aminotransferase [(31.05 ± 4.20) U/L vs. (37.24 ± 4.56) U/L], and lower gamma-glutamyltransferase [(43.35 ± 8.74) U/L vs. (57.62 ± 9.04) U/L] levels compared with the conventional group. The combined group showed higher high-density lipoprotein cholesterol level compared with the conventional group [(1.85 ± 0.26) mmol/L vs. (1.26 ± 0.30) mmol/L]. All differences were statistically significant ( t = 2.85, 4.00, 9.31, 10.84, 5.88, 4.48, 6.24, 7.09, 9.28, all P < 0.05). Conclusions:The combination of auricular acupressure and massage-tapping exercises is effective in treating obesity-related fatty liver disease in patients. This approach can regulate physical indicators, improve lipid metabolism, and enhance liver function, making it a method worth promoting in clinical practice.

Objective:To investigate the efficacy of pelvic floor neuromuscular stimulation combined with progesterone in the treatment of pelvic floor function recovery after hysterectomy.Methods:This study used a randomized controlled design, involving 108 patients with pelvic floor dysfunction who underwent hysterectomy at Shaanxi Provincial People's Hospital between January 2021 and December 2023. These patients were randomly assigned to either a control group or an observation group, with 54 patients in each group, using a random number table for allocation. Both groups received basic pelvic floor muscle training. The control group was treated solely with progesterone vaginal soft capsules, while the observation group also received neuromuscular stimulation through pelvic rehabilitation equipment. Before and after treatment, changes in muscle strength (measured by electromyography values of type I and type II muscle fibers), quality of life (assessed using the Pelvic Floor Dysfunction Index Questionnaire-7 and the Pelvic Floor Distress Inventory-Short Form 20), pelvic relaxation indicators (levels of laminin, relaxin, and transforming growth factor beta-3), and Pelvic Organ Prolapse Quantification staging were compared between the two groups. Additionally, stress urinary incontinence, lumbosacral pain, sexual satisfaction, vaginal prolapse conditions, and overall efficacy post-treatment were compared between the two groups.Results:After treatment, electromyography values for type I and type II muscle fibers in the observation group were (4.71 ± 0.61) μA and (5.63 ± 0.79) μA, respectively, which were significantly higher than those in the control group [(3.51 ± 0.53) μA, (4.53 ± 0.50) μA, t = -10.91, -8.65, both P < 0.001]. The scores for the Pelvic Floor Dysfunction Index Questionnaire-7 and Pelvic Floor Distress Inventory-Short Form 20 in the observation group were (4.56 ± 0.64) and (4.56 ± 0.64), respectively, both of which were significantly lower than those in the control group [(5.36 ± 0.70), (5.36 ± 0.70), t = 6.20, 26.74, both P < 0.001]. The levels of laminin, relaxin, and transforming growth factor beta-3 in the observation group were (27.28 ± 3.00) μg/L, (53.32 ± 6.40) μg/L, and (28.25 ± 3.67) mg/L, respectively, all of which were significantly lower than those in the control group [(32.14 ± 3.54) μg/L, (59.22 ± 6.51) μg/L, (36.25 ± 3.99) mg/L, t = 7.70, 4.75, 10.84, all P < 0.001]. The proportion of patients in the observation group with a POP-Q stage of 0 was 90.74% (49/54), which was significantly higher than that in the control group [68.52% (37/54), χ2=8.22, P < 0.05]. The proportion in the observation group with a stage of 1 was 7.41% (4/54), which was significantly lower than that in the control group [25.93% (14/54), χ2 = 6.67, P < 0.05]. The incidence rates of stress urinary incontinence, lumbosacral pain, sexual dissatisfaction, and vaginal prolapse in the observation group were all significantly lower than those in the control group ( χ2 = 4.41, 4.36, 4.70, 4.41, all P < 0.05). The overall effective rate in the observation group was 92.59% (50/54), which was significantly higher than that in the control group [74.07% (40/54), χ2 = 6.67, P < 0.05]. Conclusions:Pelvic floor neuromuscular stimulation combined with progesterone vaginal soft capsules can improve muscle strength in patients with pelvic floor dysfunction after hysterectomy, enhance life satisfaction, relieve pelvic relaxation, and promote comprehensive recovery of pelvic function.

Objective:To analyze the risk factors for dysphagia in older adult patients with Parkinson's disease.Methods:The clinical data of 100 older adult patients with Parkinson's disease admitted to Zhejiang Xin'an International Hospital between January 2022 and December 2023 were retrospectively analyzed. The patients were divided into two groups based on the presence of dysphagia: an occurrence group ( n = 40) and a non-occurrence group ( n = 60). General data and clinical characteristics of both groups were compared. Multivariate logistic regression analysis was performed to analyze the risk factors associated with the occurrence of dysphagia in older adult patients with Parkinson's disease. Results:In the cohort of 100 patients, the percentages of those aged 70 years and above, those with a Parkinson's disease H-Y classification greater than 3, those with an Eating Assessment Tool-10 (EAT-10) score of 3 or higher, and the Unified Parkinson's Disease Rating Scale (UPDRS) score in the occurrence group were 75.00% (30/40), 75.00% (30/40), 80.00% (32/40), and (17.23 ± 1.02), respectively. These measurements were higher than those in the non-occurrence group [16.67% (28/60), 43.33% (26/60), 33.33% (20/60), (13.23 ± 0.48), χ2 = 7.91, 9.77, 20.94, t = 22.44, P < 0.05]. The level of uric acid in the occurrence group was significantly lower than that in the non-occurrence group [(345.63 ± 11.35) μmol/L vs. (375.62 ± 10.24) μmol/L, t = 12.41, P < 0.05]. The results of the multivariate logistic regression analysis indicated that age of 70 years and older, H-Y classification greater than 3, Eating Assessment Tool-10 score of 3 or higher, Unified Parkinson's Disease Rating Scale score, and uric acid level were relevant risk factors for dysphagia in older adult patients with Parkinson's disease ( OR = 3.44, 3.82, 3.86, 3.60, 3.71, all P < 0.05). Conclusions:Age of 70 years and older, H-Y classification greater than 3, Eating Assessment Tool-10 score of 3 or higher, Unified Parkinson's Disease Rating Scale score, and uric acid level are relevant risk factors for dysphagia in older adult patients with Parkinson's disease.