As a tool for evaluating the value of drugs,Economic Evaluation(EE)models are playing an increasingly important role in healthcare and reimbursement decision-making in China.However,the lack of transparency and the uncertainty surrounding the results of these EE models have significantly hindered the translation of research evidence into policy decisions.Constructing a disease reference model provides a critical approach to address these challenges.First,starting from the concept of disease reference model,it compares its differences with traditional economics evaluation models and analyzes the key steps involved in their construc-tion;secondly,it takes advanced lung cancer,diabetes mellitus,and osteoporosis as typical cases to illustrate the main features and the current development of disease reference models;and it finally analyzes the advantages and challenges of the development of disease reference models in China.By systematically reviewing the methods and applications of disease reference models,it con-tributes to the exploration of future directions for economic evaluation models and promotes the high-quality development and deci-sion-making translation of pharmacoeconomics in China.

Objective:To analyze the policy evolution logic of drug supply security,in order to provide references for the improvement of China's drug supply security policy.Methods:Policy documents related to drug supply security at the national level from the founding of New China to 2024 are systematically summarized.The policy texts are coded to reveal the key issues of the policy,and the logic of policy evolution is analyzed from the perspective of the synergy among health insurance,medical care and pharmaceuticals.Results:China's drug supply security policy as a whole has practiced the evolutionary logic of"strict control,"gradual relaxation","synergistic development".The guarantee of drug supply must adhere to the interactive and integrated decision-making under the synergistic perspective of medical care,medical insurance and pharmaceuticals,while taking into account the attributes of quasi-public goods and the attributes of commodities in general.Conclusion:The security of drug supply is not simply a matter of medication,while the promotion of the high-quality development of the health security system and the improvement of the health status of the entire population are more important.

Metering unit is important component of medical service items and also serve as significant bases for scientifically estimating the costs of medical services.National Technical Specification of Medical Service Items(2023 Edition)has set up elements such as"metering unit"and"adjustment coefficient for resource consumption in special circumstances",which clearly stipulate the metering units of each medical service item and the multiples for discretionary increases or decreases in the overall resource consumption when special circumstances occur.These two elements are important references for the cost accounting in medical institutions.The project team has elaborated on the definitions,establishment principles and special circumstances of these two types of elements,namely"metering units"and"adjustment coefficient for resource consumption in special circumstances",providing references for the application of relevant governments and healthcare institutions.

The relative value of human resource consumption is a relative value scale of the workload and difficulty of medical personnel needed to provide medical service items.Based on"basic human resource consumption and time consumption","technical difficulty"and"risk level"of the medical service items,it is comprehensively calculated by"relative value indicator standardization","relative value indicator weight setting","relative value indicator calculation model construction",and"relative value indicator expert verification".By formulating the relative value of human resource consumption,it could be used in rationalizing the relative value scale of medical service items,promoting cost accounting in hospitals,and establishing a scientific and reasonable performance evaluation system as technical tools.

Objective:To plot Kaplan-Meier curves using simulated survival data and compare the characteristics of different survival probability extraction methods for Kaplan-Meier curves and their performance across various scenarios.Methods:Survival datasets were simulated using R-4.4.2 with parameters including sample sizes,censoring marker,and curve numbers.GetData Graph Digitizer,IPDfromKM getpoints,SurvdigitizeR survival_digitize were evaluated.A JavaScript script was developed to extract Kaplan-Meier curve.Root Mean Square Error(RMSE)was calculated to quantify deviations between digitized and true survival probabilities.Results:The JavaScript script method demonstrated the smallest RMSE across all simulated scenarios(RMSE=1.015×10-4),significantly outperforming the other three methods(P＜0.05),with statistically significant differences observed among methods(P＜0.05).Conclusion:For vector format illustrations,JavaScript scripts enable accurate and robust reverse engineering of Kaplan-Meier curves;for bitmaps,the GetData Graph Digitizer and SurvdigitizeR survival_digitize methods yield more accurate results,and the SurvdigitizeR survival_digitize method is the most efficient.Future research should focus on integrating intelligent algorithms for enhanced robustness and precision in survival data reconstruction.

Objective:To analyze the underlying issues and root causes of primary healthcare resource allocation in China,to identify the key elements of the current mismatch in primary healthcare resource allocation,and to propose targeted optimization strategies.Methods:Utilizing the fuzzy set Qualitative Comparative Analysis(fsQCA)method to conduct a comprehensive investigation on the fundamental drivers of misallocation in the provision of primary healthcare resources in China,along with the associated grouping patterns.Results:From 2011 to 2021,the overall misallocation of primary medical and health resources in 31 provinces and cities of China showed a downward trend,with the average value decreasing from 0.801 to 0.661.There were 8 configuration paths to improve the optimal allocation of primary medical resources,including 2 biased factors-driven,4"system,society,and population"three-way synergistic types,and 2 multi-factor comprehensive synergistic types.Conclusion:It is recommended that all provinces need to adhere to the principle of government leadership and promote comprehensive reform of the medical and healthcare sector,with particular consideration given to the specific medical needs of the elderly.Furthermore,it is essential to implement the strategic guiding principle of diversified and synergistic development,with the objective of promoting a balanced distribution of high-quality medical resources.

In September 2023,the issues of National Technical Specification of Medical Service Items(Version 2023)and Financial Classification of Medical Service Items provide national-level standards and guidance for regulating healthcare facilities'charging practices and economic operation management.It highlights the overarching design principles,structural frameworks,and practical implementation approaches of National Technical Specification of Medical Service Items(Version 2023),in order to provide comprehensive support and directional guidance for fee regulation,cost accounting,performance evaluation,and other critical areas.

As an important indicator to assess the revenue structure of hospitals,healthcare service revenue can truly reflect the labor value of medical personnel.A unified financial classification is the premise of accurate calculation of revenue structure.Meeting the needs of financial management of medical institutions through mapping with current healthcare service items in various regions,Financial Classification of Medical Service Items has unified the financial classification from the aspects of bill classification,accounting subject and expense classification in medical record.

Objective:To examine the impact and mechanisms of the direct settlement of nonlocal medical expenses policy on migrant health and quantify its inter-provincial medical insurance fund flow effects.Methods:Using China Labor-Force Dynamics Survey data and city-level policy implementation data,a staggered difference-in-differences model evaluates the policy's health benefits for migrants.Models based on migrant distribution,medical costs,and reimbursement rates estimate 2023 provincial medical fund changes and forecast future expenditure shares from 2026-2030.Results:The policy increases the likelihood of migrants reporting good health by approximately 4.4%,likely through higher reimbursement rates,increased education spending,and improved social integration.Guizhou and Anhui face the highest migrant-related net expenditure shares.Conclusion:The policy significantly enhances migrant health,with rigid costs ensuring equal rights in destination regions.However,inter-provincial disparities call for a regional balance mechanism to manage fund expenditures in high-quality urbanization.

Objective:In order to advance the upgrade of the Traditional Chinese Medicine(TCM)"preventive healthcare"project and develop high-quality TCM preventive healthcare services.Methods:Utilizing stakeholder theory to identify the stakeholders of current TCM health preservation services,and analyze the core stakeholders'interest relationships,influence,connection strength,policy impact,and the recognition degree for TCM"preventive healthcare".Results:It describes the economic connotations and current development status of TCM"preventive healthcare"services,where the core stakeholders include government and functional departments,medical insurance departments,medical institutions,medical and health technicians,and patient groups.By comparing the interest descriptions of core stakeholders,the existing problems are analyzed.Conclusion:The government should improve policy management and promote departmental collaboration.Medical insurance departments need to strengthen policy coordination and product development.Medical institutions should establish a multi-level service system,optimize the service model,improve the incentive mechanism for medical and health technicians,and enhance service capabilities.The patient group should enhance health awareness and optimize the service experience.Through the management strategy driven by interests,it can promote the high-quality development of TCM preventive treatment services and meet the health needs of the residents.