Objective To explore the effect of diversified hand function exercise under the mode of collaborative nursing management on the rehabilitation of cerebral infarction patients with hand dysfunction.Methods A total of 100 patients with cerebral infarction and hand dysfunction diagnosed and treated in the Second Affiliated Hospital of Nanchang University from July 2021 to January 2023 were prospectively selected as study objects,and divided into combined group(n=50)and control group(n=50)according to stratified random sampling method.Patients in control group received routine treatment and rehabilitation training,and patients in combined group were combined with diversified hand function exercise under the mode of collaborative nursing management on the basis of control group.Fugl-Meyer assessment(FMA)scale,stroke-specific quality of life scale(SS-QOL),visual analogue scale(VAS)score before and after intervention,and rehabilitation compliance,rehabilitation training satisfaction were compared between two groups.Results After 3 months of intervention,FMA scale score and SS-QOL score of patients in two groups were significantly higher than before intervention,VAS score and swelling degree were significantly lower than before intervention(P<0.05).FMA scale score and SS-QOL score of combined group were significantly higher than those of control group,and VAS score and swelling degree were significantly lower than those of control group(P<0.05).The muscle strength,rehabilitation compliance and rehabilitation satisfaction of combined group were significantly higher than those of control group(P<0.05).Conclusion Diversified hand function exercise under the mode of collaborative nursing management can improve the limb motor function and quality of life of cerebral infarction patients with hand dysfunction,relieve pain and swelling,and improve the rehabilitation compliance of patients,which is worthy of clinical promotion and use.

Objective To explore the effect of improved operating room nursing on vitrectomy patients with diabetic retinopathy based on change theory.Methods A total of 100 patients with diabetic retinopathy who underwent vitrectomy in Affiliated Eye Hospital of Nanchang University from January to December 2023 were selected as study objects.Fifty patients admitted from January to June 2023 were included in control group and received routine nursing in operating room after vitrectomy,and fifty patients admitted from July to December 2023 were included in experimental group to receive improved operating room nursing based on change theory.Operation time,postoperative intraocular pressure,operative stress index,complications and nursing satisfaction were compared between two groups.Results The operation time of experimental group was significantly shorter than that of control group,and the postoperative intraocular pressure was significantly lower than that of control group(P<0.05).At the end of operation,heart rate,mean arterial pressure and mixed venous blood oxygen saturation of two groups were significantly higher than those before operation(P<0.05),heart rate and mean arterial pressure of experimental group were significantly lower than those of control group,and mixed venous blood oxygen saturation was significantly higher than that of control group(P<0.05).The complication rate of experimental group was significantly lower than that of control group(P<0.05).The nursing satisfaction score of experimental group was significantly higher than that of control group(P<0.05).Conclusion The application of improved operating room nursing based on change theory to vitrectomy patients with diabetic retinopathy can shorten the operation time,reduce the stress of surgery,promote postoperative recovery,reduce the incidence of complications,and improve the satisfaction of operating room nursing.

Objective To explore the effects of methimazole on endocrine function in patients with hyperthyroidism at different neuregulin 4(NRG4)levels.Methods A total of 60 patients with hyperthyroidism admitted to Huzhou First People's Hospital from January 2022 to January 2023 were selected.According to the level of NRG4,they were divided into case Ⅰ group(NRG4<80ng/ml,28 cases),case Ⅱ group(NRG4 80-120ng/ml,18 cases)and case Ⅲ group(NRG4>120ng/ml,14 cases).The clinical efficacy,thyroid hormone levels,glucose and lipid metabolism indexes and adverse reactions of three groups were compared.Results The difference of total effective rate among three groups was statistically significant(χ2=10.836,P<0.001).There were statistically significant differences in thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)between groups,time points and interactions among three groups(P<0.05).TSH levels increased and FT3 and FT4 levels decreased in all three groups after treatment(P<0.05).One month after treatment,the levels of fasting blood glucose,2h postprandial blood glucose,glycated hemoglobin,total cholesterol and low density lipoprotein cholesterol in three groups were significantly lower than before treatment(P<0.05),and the differences in above indicators among the three groups were statistically significant(P<0.05).There was no significant difference in total incidence of adverse reactions among three groups(χ2=5.349,P=0.069).After treatment,NRG4 levels in three groups decreased significantly over time(P<0.05).There were significant differences in NRG4 levels among the three groups at different time points(P<0.05),and case Ⅰ group

Objective To explore the mediating effect of negative emotion and rumination on the quality of discharge guidance and discharge readiness of patients after coronary artery bypass grafting.Methods A total of 288 patients who underwent coronary artery bypass surgery in the Second Affiliated Hospital of Nanchang University from February 2022 to February 2024 were selected as study objects.General data questionnaire,self-rating anxiety scale(SAS),self-rating depression scale(SDS),Chinese version of event related rumination inventory(CERRI),quality of discharge teaching scale(QDTS),readiness for hospital discharge scale(RHDS)were used to investigate,and Amos 24.0 structural equation model was used to analyze the chain mediation effect.Results A total of 288 questionnaires were sent out,and 280 valid questionnaires were recovered,with an effective recovery rate of 97.22％.The patients'SAS scores were(57.83±5.32)points,SDS scores were(63.31±4.97)points,CERRI total scores were(31.03±4.76)points,QDTS total scores were(116.78±9.22)points,and RHDS total scores were(79.30±7.21)points.The RHDS scores of patients who lived alone after discharge,paid at their own expense and had grade Ⅲ heart function were significantly lower than those of patients with nursing care,medical insurance payment and grade Ⅰ heart function after discharge(P<0.05).Anxiety was positively correlated with depression,intrusive rumination,but negatively correlated with purposive rumination,quality of discharge guidance and discharge readiness.Depression was positively correlated with intrusive rumination,but negatively correlated with purposive rumination,quality of discharge guidance and discharge readiness.Invasive rumination was negatively correlated with purposive rumination,quality of discharge guidance and discharge readiness.Purposive rumination was positively correlated with the quality of discharge guidance and discharge readiness.The quality of discharge guidance was positively correlated with discharge readiness(P<0.05).The chain-mediated model was well fitted,and the results showed that the quality of patients'discharge guidance could affect their discharge readiness,while negative emotions and rumination pathways also affected their discharge readiness(P<0.05).Conclusion The quality of discharge guidance can directly or indirectly affect the discharge readiness of patients after coronary artery bypass grafting through negative emotions and rumination,and there is a chain mediation effect.

Objective To analyze the hotspots and frontiers of traditional Chinese medicine treatment for allergic rhinitis(AR)in China,aiming to provide reference for the treatment of AR patients in China.Methods Literatures related to traditional Chinese medicine treatment of AR published by CNKI,Wanfang Data and VIP database from January 2004 to December 2023 were searched,and CiteSpace software was used for visual analysis of the number of literatures,key words,research institutions and authors.Results A total of 1604 literatures were included,and the annual number of literatures generally showed an upward trend.The research frontiers in the last 5 years include medication patterns,immune function,quality of life,data mining,and thumbtack needle.The top five institutions in terms of publications were Beijing University of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Nanjing University of Traditional Chinese Medicine,the First Affiliated Hospital of Beijing University of Traditional Chinese Medicine,and Chengdu University of Traditional Chinese Medicine.The core authors were Yuan Weiling,Yan Daonan,Zhao Jiping,Zhang Qinxiu,and Feng Weiyun.Conclusion The application of traditional Chinese medicine in treatment of AR has always been in a high research heat,and giving full play to the characteristics of traditional Chinese medicine can be the development direction of AR research in the future.

Objective To investigate the clinical efficacy and safety of modified single-port thoracoscopic sympathectomy combined with disconnection ventilation in the treatment of primary palmar hyperhidrosis(PPH).Methods The perioperative indexes,clinical efficacy and postoperative complications of 20 patients with PPH who underwent modified single-port thoracoscopic sympathectomy combined with disconnection ventilation in Wuming Hospital of Guangxi Medical University from June 2020 to July 2024 were retrospectively analyzed.Results All patients successfully completed the operation without serious complications and death.The average operation time was(56.15±16.00)min,and the average intraoperative blood loss was(3.35±1.39)ml.The treatment effective rate was 100%,the average postoperative hospitalization time was(2.15±0.86)days,and the average hospitalization cost was(9485.56±1601.77)yuan.During the follow-up period of 1 to 45 months,there were no recurrent cases and no obvious cases of compensatory hyperhidrosis.Conclusion The modified single-port thoracoscopic sympathectomy combined with disconnection ventilation has good efficacy and safety in the treatment of PPH.

Objective Based on the analysis of the results of retesting of blood donors with human immunodeficiency virus(HIV)serological single-reagent reactivity,the rationality and practical effect of the existing retesting strategy were discussed.Methods HIV serological single-reagent reactivity blood donors in Wenzhou from January to December 2023 were selected as the study objects,and were confirmed by Wenzhou Center for Disease Control and Prevention(CDC)and returning test to confirm whether they could be returnee.Differences in return rates were analyzed by the basic data of blood donors and the S/CO value of HIV serological test during screening.Results Among the 374 HIV serological single-reagent reactivity blood donors,55 were confirmed by CDC with uncertain HIV antibodies,319 met the criteria for return,and 84 actively applied for return.78 showed no reactivity through self-test and return test and were allowed to return to the team.Four showed HIV serological reactivity,one showed HIV nucleic acid testing(NAT)test reactivity,permanent shielding.One showed the reactivity of anti-HIV chemiluminescence immunoassay test,and the HIV NAT test was noreactivity,and continued to be screened to participate in the next round of return.There were statistically significant differences in the permissible return rate of blood donors with different ages,blood types and blood donation times(P<0.05).There was no significant difference in the allowed return rate of blood donors with different S/CO values during screening(χ2=1.898,P=0.168).Conclusion Reasonable return procedures can effectively reduce the loss of blood donors and ensure the safety of blood for clinical use.

Objective To investigate the predictive value of serum albumin(ALB),C-reactive protein(CRP)and globulin(GLB)in recurrent diabetic foot ulcers(DFU).Methods A total of 101 DFU patients admitted to Wuhan Third Hospital from January 2020 to November 2023 were selected as study objects.According to whether the patients had recurrent DFU,they were divided into recurrent group(59 cases)and control group(42 cases).The clinical data of two groups were compared,and the influencing factors of recurrent DFU were analyzed by Logistic regression.Receiver operating characteristic curve was drawn to analyze the predictive value of serum ALB,CRP and GLB for recurrent DFU.Results The body mass index,hemoglobin and ALB in recurrent group were significantly lower than those in control group,while the levels of CRP,GLB,prealbumin and creatinine were significantly higher than those in control group(P<0.05).Logistic regression analysis showed that ALB was an independent protective factor for DFU recurrence(P<0.05),CRP and GLB were independent risk factors for DFU recurrence(P<0.05).The area under the curve(AUC)of ALB,CRP and GLB for predicting recurrent DFU were 0.782(95%CI:0.691-0.874),0.824(95%CI:0.742-0.906)and 0.686(95%CI:0.582-0.790),respectively.The AUC for the combined prediction of recurrent DFU was 0.849(95%CI:0.775-0.922).Conclusion Serum ALB levels were decreased in patients with recurrent DFU,while CRP and GLB levels were increased.ALB,CRP and GLB have a certain predictive value for recurrent DFU,and the combined predictive value is higher.

Objective To investigate the influencing factors of grade 3-4 multiple myeloma bone disease(MBD)in newly diagnosed multiple myeloma(NDMM)patients,and establish a risk prediction model based on a nomogram.Methods A total of 261 patients with NDMM who were treated in Ningbo Medical Center Lihuili Hospital from January 2015 to December 2021 were retrospectively selected.The patients were divided into group A(MBD grade 0-2,110 cases)and group B(MBD grade 3-4,151 cases)according to MBD grade at the time of initial diagnosis.Logistic regression analysis was used to screen the risk factors for grade 3-4 MBD in NDMM patients,and the risk prediction model was constructed.The receiver operating characteristic(ROC)curve was used for comprehensive evaluation.Results Multivariate regression analysis showed that age,serum phosphorus,C-reactive protein(CRP),globulin(GLB)and bone marrow plasma cell percentage(BMPCp)were independent risk factors for grade 3-4 MBD in NDMM patients(P<0.05).Based on this,risk prediction model was constructed as follows:logit(P)=-15.092+0.107(age)+1.150(serum phosphorus)+0.057(CRP)+0.040(GLB)+0.212(BMPCp).There was no significant difference between the predicted probability and the actual incidence by the Hosmer-Lemeshow goodness of fit test(P=0.770).The accuracy of the model in predicting grade 3-4 MBD in NDMM patients was 90.40%,and the area under the curve was 0.957(95%CI:0.932-0.981),indicating a reliable prediction ability.Conclusion Age,serum phosphorus,CRP,GLB and BMPCp were all independent risk factors for grade 3-4 MBD in NDMM patients,and the constructed risk prediction model has a relatively good predictive effect on the occurrence of grade 3-4 MBD in NDMM patients.

Objective To calculate and analyze the research and development(R&D)efficiency,as well as the technological achievements transformation efficiency,of ten"Double First-Class"medical universities and ten medical universities in the accumulative science and technology evaluation metrics over the last five years,in order to make recommendations for improving technological achievements transformation management at these universities.Methods The study used both classic data envelopment analysis and super-effectiveness data envelopment analysis models to assess the effectiveness of the R&D stage and technological achievements transformation stage at the selected medical universities.Furthermore,the Malmquist model was used to measure the changes in the efficiency of the transformation of scientific and technological achievements of the medical universities as a whole.Results Among the 20 medical universities chosen,the output efficiency in the R&D stage was greater than that in the technological achievements transformation stage.Five medical universities were output-effective at the R&D stage,and two medical universities were in the technological achievements transformation stage.The overall efficiency of scientific and technological achievements transformation in medical universities was steadily improving.Conclusion Based on the current situation,medical universities in China should strengthen effective collaboration between industry,academia,and research,establish professional teams for technological achievements transformation,improve the technological achievements transformation management system,improve talent team construction,and increase technological achievements transformation efficiency.