Excessive alcohol consumption, whether chronic or sudden, can lead to serious health issues. To mitigate these risks, it is essential to disseminate accurate information about alcohol consumption while fostering awareness and behavioral change. Previously, we developed a 10-minute video on “Alcohol Metabolism and Genetic Polymorphism” as a tool to aid in the prevention of alcohol-related diseases. We assessed its effectiveness among pharmacy students by administering pre- and post-viewing tests, with results indicating that it served as an effective educational tool within a short period. To extend this educational approach beyond pharmacy students, who generally possess higher levels of expertise and health consciousness, it is necessary to create an illustrated video incorporating visual effects and conduct a survey to evaluate its impact across a wide range of ages. Therefore, in order to clarify the effectiveness of the improved illustrated video lecture, we evaluated it with pre- and post-viewing tests on university festival participants and showed that it can improve the comprehension of people up to their 60s. These data suggest that illustrated video lectures can be an effective educational tool for spreading knowledge on alcohol consumption. Further research is needed to determine whether increased knowledge leads to changes in drinking behavior and prevention of alcohol-related social problems.

BACKGROUND: To develop human space exploration, it is necessary to study the effects of an isolated and confined environment, as well as a microgravity environment, on cerebral circulation. However, no studies on cerebral circulation in an isolated and confined environment have been reported. Therefore, we investigated the effects of a 14-day period of confinement in an isolated environment on dynamic cerebral autoregulation. METHODS: We participated in an isolation and confinement experiment conducted by the Japan Aerospace Exploration Agency in 2016. Eight healthy males were isolated and confined in a facility for 14 days. Data were collected on the days immediately before and after confinement. Arterial blood pressure waveforms were obtained using a finger blood pressure monitor, and cerebral blood flow velocity waveforms in the middle cerebral artery were obtained using transcranial Doppler ultrasonography for 6 min during quiet rest in a supine position. Dynamic cerebral autoregulation was evaluated by transfer function analysis between spontaneous variability of beat-to-beat mean arterial blood pressure and mean cerebral blood flow velocity. RESULTS: Transfer function gain in the low- and high-frequency ranges increased significantly (0.54 ± 0.07 to 0.69 ± 0.09 cm/s/mmHg and 0.80 ± 0.05 to 0.92 ± 0.09 cm/s/mmHg, respectively) after the confinement. CONCLUSION: The increases observed in transfer function gain may be interpreted as indicating less suppressive capability against transmission from arterial blood pressure oscillation to cerebral blood flow velocity fluctuation. These results suggest that confinement in an isolated environment for 14 days may impair dynamic cerebral autoregulation. TRIAL REGISTRATION UMIN000020703 , Registered 2016/01/22.
Adult ; Cerebrovascular Circulation ; physiology ; Confined Spaces ; Homeostasis ; physiology ; Humans ; Male ; Middle Aged ; Space Flight ; Young Adult