Objective To study the differences in dynamic stability characteristics between older and young adults during continuous turning and walking in different directions.Methods Fifteen healthy older adults and 15 healthy young adults were recruited to complete continuous clockwise and counterclockwise figure-of-8 walk.A three-dimensional motion capture system was used to collect kinematic data based on 43 bone markers.The gait and velocity of the center of mass parameters were determined using V3D software.The margins of stability in both the anterior and medial direction at characteristic moments were calculated.Results Compared with clockwise turning,the step width of the inner leg increased and the anterior margin of stability of the inner leg at the toe-off instant decreased during counterclockwise turning in young adults.Meanwhile,there were no significant differences in the above parameters for older adults.Conclusions Both the age and turning direction affected the forward dynamic stability of the inner leg at the toe-off instant.Healthy older adults adopted more cautious strategies to maintain anterior and medial stability during continuous walking.It is recommended that older adults should increase turning training in daily life to improve their medial-lateral control capability and confidence in turning.

Objective To study the differences in dynamic stability characteristics between older and young adults during continuous turning and walking in different directions.Methods Fifteen healthy older adults and 15 healthy young adults were recruited to complete continuous clockwise and counterclockwise figure-of-8 walk.A three-dimensional motion capture system was used to collect kinematic data based on 43 bone markers.The gait and velocity of the center of mass parameters were determined using V3D software.The margins of stability in both the anterior and medial direction at characteristic moments were calculated.Results Compared with clockwise turning,the step width of the inner leg increased and the anterior margin of stability of the inner leg at the toe-off instant decreased during counterclockwise turning in young adults.Meanwhile,there were no significant differences in the above parameters for older adults.Conclusions Both the age and turning direction affected the forward dynamic stability of the inner leg at the toe-off instant.Healthy older adults adopted more cautious strategies to maintain anterior and medial stability during continuous walking.It is recommended that older adults should increase turning training in daily life to improve their medial-lateral control capability and confidence in turning.

We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults. A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included. Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory. Participants with systolic blood pressure ≽ 140 mmHg or diastolic blood pressure ≽ 90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary zinc intake and new-onset hypertension followed a J-shape (P for non-linearity < 0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake (per mg/day: hazard ratio (HR) 0.93; 95% confidence interval (CI) 0.88-0.98) in participants with zinc intake < 10.9 mg/day, and increased with the increment of zinc intake (per mg/day: HR 1.14; 95% CI 1.11-1.16) in participants with zinc intake ≽ 10.9 mg/day. In conclusion, there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults, with an inflection point at about 10.9 mg/day.
Adult ; Humans ; Cohort Studies ; Zinc ; Diet ; Hypertension/epidemiology* ; Eating ; China/epidemiology*

Objective To explore the effect of terazosin hydrochloride combined with finasteride on serum TNF-αand PSA in old patients with benign prostatic hyperplasia.Methods 64 elderly patients of benign prostatic hyperplasia were randomly divided into 2 groups, 32 cases in each group.2 groups were given routine treatment and symptomatic treatment, the control group was given finasteride; the experimental group were treated with terazosin hydrochloride combined with finasteride.A cycle of 2 groups were 28 d, a total of 1 cycle of treatment.Clinical efficacy, maximum urinary flow rate, prostate volume, residual urine volume, international prostate symptom score(IPSS), serum tumor necrosis factor alpha, prostate specific antigen level and adverse reactions were compared after the end of treatment.Results Compared with before treatment, maximum urinary flow rate (Qmax) level of 2 groups increased, prostate volume, residual urine volume, international prostate symptom score(IPSS)decreased (P<0.05), compared with the control group, maximum urinary flow rate of the experimental group was higher (P<0.05), prostate volume, residual urine volume, IPSS were lower (P<0.05), 2 groups of TNF-αand PSA levels decreased after treatment (P<0.05), compared with the control group, TNF-αand PSA levels were lower(P<0.05).There was no significant difference in adverse reactions in 2 groups.Conclusion Terazosin hydrochloride combined with finasteride had a clinical efficacy of elderly patients with benign prostatic hyperplasia, can reduce serum TNF-αand PSA levels.