Objective:To investigate the reliability and validity of the Chinese Version of Dimensional Anhedonia Rating Scale (DARS).Methods:136 subjects who were diagnosed with depressive disorder and 30 healthy controls were selected to complete the Chinese version of DARS, Hamilton Depression Scale (HAMD 17), and Hospital Anxiety and Depression Scale (HADS). Cronbach’s alpha coefficient, test-retest reliability and confirmatory factor analysis were conducted. HADS and HAMD 17 were considered as the gold standard to investigate the criterion validity of the Chinese version of DARS. Results:The Cronbach’s α of the Chinese version of DARS was 0.97, the coefficient of the four domains ranged from 0.89 to 0.96. The intraclass correlation coefficient ( ICC) of test-retest reliability was 0.97， ICC of four domains ranged from 0.89 to 0.95 ( P<0.01)．The results of confirmation factor analysis of the Chinese version of DARS were as followed: χ 2/ df=2.02, GFI=0.88, RMSEA=0.08, CFI=0.96, and TLI=0.96. Validity: The total score and four domains of the Chinese version of DARS were significantly correlated with the seventh item of HAMD ( r=-0.38- -0.52, P<0.01) and all five items of HADS score ( r=-0.57- -0.75, P<0.01). There was significant difference between depression group and health control group. Conclusion:The Chinese version of DARS has good psychometric properties with adequate reliability and validity, and could be applied to assess the anhedonia of depression in China.

Objective:To investigate the reliability and validity of the Chinese Version of Dimensional Anhedonia Rating Scale (DARS).Methods:136 subjects who were diagnosed with depressive disorder and 30 healthy controls were selected to complete the Chinese version of DARS, Hamilton Depression Scale (HAMD 17), and Hospital Anxiety and Depression Scale (HADS). Cronbach’s alpha coefficient, test-retest reliability and confirmatory factor analysis were conducted. HADS and HAMD 17 were considered as the gold standard to investigate the criterion validity of the Chinese version of DARS. Results:The Cronbach’s α of the Chinese version of DARS was 0.97, the coefficient of the four domains ranged from 0.89 to 0.96. The intraclass correlation coefficient ( ICC) of test-retest reliability was 0.97， ICC of four domains ranged from 0.89 to 0.95 ( P<0.01)．The results of confirmation factor analysis of the Chinese version of DARS were as followed: χ 2/ df=2.02, GFI=0.88, RMSEA=0.08, CFI=0.96, and TLI=0.96. Validity: The total score and four domains of the Chinese version of DARS were significantly correlated with the seventh item of HAMD ( r=-0.38- -0.52, P<0.01) and all five items of HADS score ( r=-0.57- -0.75, P<0.01). There was significant difference between depression group and health control group. Conclusion:The Chinese version of DARS has good psychometric properties with adequate reliability and validity, and could be applied to assess the anhedonia of depression in China.

OBJECTIVE: To explore the molecular basis for a Chinese family affected with neurofibromatosis type I. METHODS: Peripheral blood samples were collected from the proband and his parents. Potential mutations of NF1 gene were screened by PCR and Sanger sequencing. Pathogenicity of candidate mutations was analyzed using Polyphen-2 and Provean software. RESULTS: Two mutations of the NF1 gene, including c.702G>A (synonymous mutation) and c.1733T>G (missense mutation), were discovered in the proband. Neither mutation was found in his parents and 50 healthy controls. Bioinformatics analysis indicated that the c.1733T>G mutation (p.Leu578Arg) was probably damaging. The affected codon L578 is highly conserved across various species. CONCLUSION The c.1733T>C mutation of the NF1 gene probably underlies the neurofibromatosis type I in this family.
Asian Continental Ancestry Group ; Genes, Neurofibromatosis 1 ; Humans ; Mutation ; Neurofibromatosis 1 ; genetics ; Neurofibromin 1 ; genetics ; Pedigree

The aim of this study was to evaluate the effect and relative factors of hypnosis combing medication on resistant phantom limb pain (PLP).This study presented one case report involving of the use of visualization,hypnotic imagery,suggestions procedures combing venlafaxine in the alleviation of PLP and depression.Visual analogue score (VAS) and Hamilton Rating Scale for Depression-17 items (HAMD17) were used to assess the severity of PLP and depression,which were evaluated at baseline and the end.Existing literature were reviewed.After hypnosis combing medication,PLP and depression were consistently alleviated.Hypnosis may be a useful adjunct to established strategies for the treatment of PLP.