A 40-year-old female patient was diagnosed as having left breast cancinoma and underwent modified radical mastectomy. The patient′s surgical procedure was uneventful and her vital signs were stable. After the operation,doxapram hydrochloride 100 mg injection was given by intravenous injection (about 1 minute of completing the injection)to accelerate the patient recovering from the anesthesia. The patient developed shock about 5 minutes after the injection. Her blood pressure fluctuated between 60/46 and 74/54 mmHg,blood oxygen saturation fluctuated between 58% and 74%,and wet rales were audible over both lungs. The patient immediately received oxygen inhalation via a facemask and intravenous injection of adrenaline 40 μg,furosemide 40 mg,and dexamethasone 10 mg. In addition,dopamine 80 mg dissolved in 20 ml of 0.9% sodium chloride injection was administered intravenously via an infusion pump at a rate of 8 ml/h. Twenty minutes later,the patient′s moist rales in both lungs were significantly reduced,her blood pressure was 86/52 mmHg,and oxygen saturation fluctuated between 0.84 and 0.91. On postoperative day 2,the patient had blood pressure 110/70 mmHg,oxygen saturation 0.98,and heart rate 70-80 beats/min. Auscultation revealed the patient had coarse breath sounds in both lungs and slight moist rales were heard in her right lower lung. On postoperative day 5,the patient′s condition was stable and her wound healed well and then she was discharged.

A 40-year-old female patient was diagnosed as having left breast cancinoma and underwent modified radical mastectomy. The patient′s surgical procedure was uneventful and her vital signs were stable. After the operation,doxapram hydrochloride 100 mg injection was given by intravenous injection (about 1 minute of completing the injection)to accelerate the patient recovering from the anesthesia. The patient developed shock about 5 minutes after the injection. Her blood pressure fluctuated between 60/46 and 74/54 mmHg,blood oxygen saturation fluctuated between 58% and 74%,and wet rales were audible over both lungs. The patient immediately received oxygen inhalation via a facemask and intravenous injection of adrenaline 40 μg,furosemide 40 mg,and dexamethasone 10 mg. In addition,dopamine 80 mg dissolved in 20 ml of 0.9% sodium chloride injection was administered intravenously via an infusion pump at a rate of 8 ml/h. Twenty minutes later,the patient′s moist rales in both lungs were significantly reduced,her blood pressure was 86/52 mmHg,and oxygen saturation fluctuated between 0.84 and 0.91. On postoperative day 2,the patient had blood pressure 110/70 mmHg,oxygen saturation 0.98,and heart rate 70-80 beats/min. Auscultation revealed the patient had coarse breath sounds in both lungs and slight moist rales were heard in her right lower lung. On postoperative day 5,the patient′s condition was stable and her wound healed well and then she was discharged.

Objective:To analyze the correlation of single nucleotide polymorphisms ( SNP) of ATP binding cassette transporter A1 gene (ABCA1) and lower extremity atherosclerotic disease (LEAD). Methods: The clinical data and peripheral blood were col-lected from 630 participants (314 LEAD cases and 316 normal controls) in Han population of Minnan. The 9 SNP genotypes in the ABCA1 gene were detected by Sequenom MassArray. Results:Among the 9 SNP genotypes, rs2980083 was rejected because it wasn' t in accordance with Hardy-Weinberg equilibrium. Obvious linkage disequilibrium was found between rs2066714 and rs2066715, rs1800976 and rs2246293, rs2246293 and rs2980083, and rs1800976 and rs2980083(D′>0. 9,r2 >1/3). There were no significant differences (P>0. 05) in 6 haplotypes of ABCA1 gene groups between the LEAD cases and the normal controls. No significant differ-ences (P>0. 05) were found in frequency distribution between the LEAD cases and the normal controls in 8 SNP according to the re-sults of genotype statistics. There was no onset risk of LEAD according to the gene logistic regression analysis. Conclusion:The SNPs of rs10124755, rs2980083, rs1800976, rs4149341, rs2066714, rs2066715, rs2066716, rs2230808 and rs2246293 might not correlate with the susceptibility of LEAD in Han population of Minnan.

Objective:To investigate the thoughts and methods of clinical pharmacists involving in the treatment of 2 cases of atyp-ical pathogen infection. Methods:The consultation cases of 2 patients with atypical pathogens infection were analyzed,and the consul-tation experience was summarized. Results: After the consultation, the treatment efficacy of the patients was obvious. Conclusion:Clinical pharmacists can assist doctors in improving the efficacy and safety of drug treatment.