Objective To evaluate the clinical efficacy of anterior maxillary segmental distraction osteogenesis and Le Fort Ⅰ Osteot-omy on secondary maxillary hypoplasia in patients with cleft lip and palate.Methods Twenty-five patients with maxillary hypoplasia secondary to cleft lip and palate underwent surgery in maxillofacial surgical department of the Affiliated Stomatological Hospital of Nan-jing Medical University were selected.Ten cases were treated using tooth-borne distractors for anterior maxillary distraction osteogene-sis,and fifteen cases underwent Le Fort Ⅰ Osteotomy.Cone-beam CT,positive and lateral features,speech recording and nasopharyn-geal fibroscope were taken one week before operation and one month after surgery.The clinical outcomes of the two methods and their influence on patients'speech function were measured and compared using t-test.Results Both techniques effectively advanced the maxilla and significantly improved the patients'profiles.Anterior maxillary segmental distraction osteogenesis,which was economical and minimally invasive,greater advanced the maxilla.However,the postoperative profile was better in patients undergoing Le Fort Ⅰ osteotomy,with statistically significant differences(P<0.05).Neither technique significantly affected speech,but Le Fort Ⅰ osteotomy had a greater impact on palatopharyngeal anatomy,indicated by increased soft palate length(2.01±1.71)mm,reduced thickness(0.98±0.50)mm,and increased pharyngeal depth(3.06±1.35)mm,with statistically significant differences(P<0.05).Conclusion Anterior maxillary segmental distraction osteogenesis and orthognathic surgery are both effective methods for the treatment of secondary maxillary hypoplasia in cleft lip and palate patients.Anterior maxillary distraction osteogenesis has advantages over Le Fort I osteotomy in terms of economic benefits and its impact on the soft palate structure.

OBJECTIVE: To determine serum levels of betatrophin in patients with polycystic ovary syndrome (PCOS) and the influential factors. 
 METHODS: A total of 100 PCOS patients were enrolled randomly as a PCOS group, and 40 age-matched healthy women were recruited as a normal control (NC) group. Primary clinical or biochemical parameters of the subjects were detected. The results were analyzed by SPSS 19.0.
 RESULTS: Serum betatrophin levels were elevated in the PCOS group compared with the NC group. Serum betatrophin levels were positively correlated with age and Whole Body Insulin Sensitivity Index (WBISI),and negatively correlated with body mass index, fasting insulin(FINS), homeostatic model assessment insulin resistance (HOMA-IR) and homeostatic model assessment β cell function (HOMA-β). Multiple linear stepwise regression analysis showed that age and waist hip ratio (WHR) were independent influential factors for the level of betatrophin. PCOS was more likely to occur in women with higher betatrophin levels.
 CONCLUSION Serum betatrophin levels increase in women with PCOS and they are independently associated with age and WHR. There is no significant correlation between betatrophin and insulin resistance or insulin levels.
Adult ; Age Factors ; Angiopoietin-like Proteins ; blood ; Biomarkers ; blood ; Body Mass Index ; Case-Control Studies ; Female ; Humans ; Insulin ; blood ; Insulin Resistance ; Insulin-Secreting Cells ; Peptide Hormones ; blood ; Polycystic Ovary Syndrome ; blood ; physiopathology ; Waist-Hip Ratio ; statistics & numerical data