"Zoletil 50" is a veterinary anesthetic, a compound preparation of tiletamine and zolazepam. This report describes a case involving mental and behavioral abnormalities after prolonged use of this drug. The patient had been regularly inhaling "Zoletil 50" nasally for 4 months. Following inhalation, symptoms emerged including abundant visions, dissociation, ataxia, muscle jerking, inability to walk and lung infection, along with changes of consciousness. The symptoms were eventually relieved through the administration of benzodiazepines, low-dose antipsychotic medications, and other medications. This case illustrates the potential mental effects of inhaling "Zoletil 50" and may help clinical physicians identify and manage similar psychotic disorders resulting from the use of this veterinary anesthetic.

"Zoletil 50" is a veterinary anesthetic, a compound preparation of tiletamine and zolazepam. This report describes a case involving mental and behavioral abnormalities after prolonged use of this drug. The patient had been regularly inhaling "Zoletil 50" nasally for 4 months. Following inhalation, symptoms emerged including abundant visions, dissociation, ataxia, muscle jerking, inability to walk and lung infection, along with changes of consciousness. The symptoms were eventually relieved through the administration of benzodiazepines, low-dose antipsychotic medications, and other medications. This case illustrates the potential mental effects of inhaling "Zoletil 50" and may help clinical physicians identify and manage similar psychotic disorders resulting from the use of this veterinary anesthetic.

Amine-terminated poly (ethylene glycol) (PEG) was prepared by two steps. Firstly, potassium naphthalene was added to a solution of methoxypolyethylene glycol 5,000 in benzene until the solution maintains green in half of an hour, then excess tosylchloride was introduced; secondly, the conversion of the tosylate into an amine was carried out by Gabriel synthesis. The block copolymer poly (ethylene glycol)-co-poly (gamma-benzyl L-glutamate ) could be obtained by ring-opening polymerization of gamma-benzyl-L-glutamate N-carboxy anhydride with amine-terminated PEG as macroinitiator. And the benzyl group could be removed by sodium hydroxide. The product structure was characterized by IR, 1HNMR, GPC. The cisplatin-loaded micelle was observed by transmission electron microscope (TEM). And the block copolymer is expected to be useful as functional materials including carrier systems in drug controlled delivery applications.
Drug Carriers ; Polyethylene Glycols ; chemical synthesis ; Polyglutamic Acid ; Polymers ; chemical synthesis ; chemistry ; Surface Properties