1.Erratum to "Suppression of Lipopolysaccharide-induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae" Biomol Ther 29(6), 685-696 (2021)
Seon Yeong JI ; Hee-Jae CHA ; Ilandarage Menu Neelaka MOLAGODA ; Min Yeong KIM ; So Young KIM ; Hyun HWANGBO ; Hyesook LEE ; Gi-Young KIM ; Do-Hyung KIM ; Jin Won HYUN ; Heui-Soo KIM ; Suhkmann KIM ; Cheng-Yun JIN ; Yung Hyun CHOI
Biomolecules & Therapeutics 2025;33(3):554-554
2.Erratum to "Suppression of Lipopolysaccharide-induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae" Biomol Ther 29(6), 685-696 (2021)
Seon Yeong JI ; Hee-Jae CHA ; Ilandarage Menu Neelaka MOLAGODA ; Min Yeong KIM ; So Young KIM ; Hyun HWANGBO ; Hyesook LEE ; Gi-Young KIM ; Do-Hyung KIM ; Jin Won HYUN ; Heui-Soo KIM ; Suhkmann KIM ; Cheng-Yun JIN ; Yung Hyun CHOI
Biomolecules & Therapeutics 2025;33(3):554-554
3.Erratum to "Suppression of Lipopolysaccharide-induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae" Biomol Ther 29(6), 685-696 (2021)
Seon Yeong JI ; Hee-Jae CHA ; Ilandarage Menu Neelaka MOLAGODA ; Min Yeong KIM ; So Young KIM ; Hyun HWANGBO ; Hyesook LEE ; Gi-Young KIM ; Do-Hyung KIM ; Jin Won HYUN ; Heui-Soo KIM ; Suhkmann KIM ; Cheng-Yun JIN ; Yung Hyun CHOI
Biomolecules & Therapeutics 2025;33(3):554-554
4.The Hospice and Palliative Medicine Physicians Certification Programs across Countries/Regions
Si Nae OH ; Sun-Hyun KIM ; Myung Ah LEE ; David HUI ; Masanori MORI ; Yoshiyuki KIZAWA ; Kwok-Keung YUEN ; Shao-Yi CHENG ; Josephine M CLAYTON ; Raymond NG
Journal of Hospice and Palliative Care 2025;28(2):31-39
As the demand for end-of-life care increases, the development of a well-structured training and certification system for palliative medicine specialists is becoming increasingly important. In South Korea, a certification system for palliative care physicians has been in place since 2019, managed by the Korean Society for Hospice and Palliative Care. To further develop this certification system and training process, this review aims to describe hospice and palliative medicine certification programs across eight countries/regions—the United States, the United Kingdom, Australia, Japan, Taiwan, Hong Kong, and South Korea—to identify key differences and draw insights for enhancing Korea's physician training and certification system. Most countries/regions recognize hospice and palliative medicine as medical subspecialty and provide standardized training and certification pathways. Training durations range from 1-year fellowships to multiyear structured programs with clinical experience. Japan’s tiered certification system offers a flexible approach based on care settings and physicians’ expertise. However, Korea’s system lacks in-depth clinical experience and government recognition, limiting its sustainability. To strengthen palliative care in Korea, it is essential to enhance training duration, expand clinical exposure, and foster multispecialty collaboration. A tiered certification system adapted to Korea’s healthcare environment and supported by government policy could improve both the quality and reach of palliative care services. These findings can inform future policy and educational reforms to ensure more effective and sustainable training of palliative care professionals in Korea.
5.Current treatment strategies for ovarian cancer in the East Asian Gynecologic Oncology Trial Group (EAGOT)
Yusuke KOBAYASHI ; Muneaki SHIMADA ; Masato TAMATE ; Hyun Woong CHO ; Jun ZHU ; Hung-Hsueh CHOU ; Hiroaki KAJIYAMA ; Aikou OKAMOTO ; Daisuke AOKI ; Sokbom KANG ; Jeong-Won LEE ; Jae-Weon KIM ; Jae-Hoon KIM ; Zhongqiu LIN ; Jihong LIN ; Xiaohua WU ; Hung-Cheng LAI ; Ting-Chang CHANG ; Chyong-Huey LAI ; Yong Man KIM ; Takayuki ENOMOTO
Journal of Gynecologic Oncology 2024;35(3):e87-
Ovarian cancer, notable for its severe prognosis among gynecologic cancers, has seen substantial progress in treatment approaches recently. Enhanced protocols in chemotherapy and the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors for maintenance therapy have markedly improved outcomes for patients with specific genetic profiles, such as those positive for BRCA mutations or exhibiting homologous recombination deficiency (HRD). Additionally, the method of intraperitoneal chemotherapy administration has emerged as a valuable alternative to traditional transvenous routes, showing promise for wider clinical adoption. The field of surgery has also evolved, with increasing exploration into the benefits and feasibility of laparoscopic methods over more invasive traditional surgeries, aiming for complete tumor removal but with reduced patient impact. The hereditary nature of ovarian cancer underscores the importance of genetic testing, which has become integral in tailoring treatment strategies, particularly in determining suitability for PARP inhibitors.The formation of the East Asian Gynecologic Oncology Trial Group (EAGOT) aims to optimize treatment across Japan, Korea, China, and Taiwan. The ovarian cancer committee of EAGOT shared the current policies, focusing on 5 topics: 1) strategies for maintenance therapy after initial surgery and chemotherapy, 2) drug regimens for platinum-sensitive and platinum-resistant recurrence, 3) intraperitoneal chemotherapy, 4) laparoscopic surgery as an alternative to laparotomy, and 5) current status of genetic testing (BRCA, HRD, and panel tests) for ovarian cancer and its prospects. EAGOT’s multi-national trials aim to harmonize these evolving treatment strategies, ensuring that the latest and most effective protocols are accessible across the region, thereby significantly impacting patient outcomes in East Asia.
6.Impact of adjuvant treatment on survival in patients with 2023 FIGO stage IIC endometrial cancer: a retrospective analysis from two tertiary centers in Korea and Taiwan
Yoo-Young LEE ; Yen-Ling LAI ; Myeong-Seon KIM ; Koping CHANG ; Hyun-Soo KIM ; Wen-Fang CHENG ; Yu-Li CHEN
Journal of Gynecologic Oncology 2024;35(3):e33-
Objective:
In early-stage endometrial cancer, aggressive histologic types (grade 3 endometrioid, serous, clear cell, carcinosarcomas, undifferentiated, mixed, and other unusual types) are associated with an increased risk of distant metastases and worse survival. However, the optimal adjuvant treatment for these patients remains controversial. The present study investigated the outcomes of different adjuvant treatments in patients with 2023 FIGO stage IIC endometrial cancer.
Methods:
We retrospectively identified patients with 2023 FIGO stage IIC endometrial cancer who underwent surgery followed by either adjuvant treatment or observation from 2000 to 2020 at two tertiary centers in Korea and Taiwan. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Kaplan-Meier estimates and Cox proportional-hazards models. We also analyzed recurrence patterns after different adjuvant treatments.
Results:
A total of 272 patients were identified; 204 received adjuvant treatment postoperatively, whereas 68 only underwent observation. Adjuvant treatment was not associated with improved RFS or OS. Non-endometrioid histologic types (p=0.003) and presence of lymphovascular space invasion (LVSI, p=0.002) were associated with worse RFS, whereas only non-endometrioid histologic types impacted OS (p=0.004). In subgroup analyses, adjuvant treatment improved OS in patients with LVSI (p=0.020) and in patients with both LVSI and grade 3 endometrioid histologic type (p=0.007). We found no difference in locoregional and distant recurrence between patients undergoing adjuvant treatment or observation.
Conclusion
In this study, the addition of adjuvant treatment was associated with an OS benefit for patients with LVSI, especially those with grade 3 endometrioid tumors.
7.Current treatment strategies for ovarian cancer in the East Asian Gynecologic Oncology Trial Group (EAGOT)
Yusuke KOBAYASHI ; Muneaki SHIMADA ; Masato TAMATE ; Hyun Woong CHO ; Jun ZHU ; Hung-Hsueh CHOU ; Hiroaki KAJIYAMA ; Aikou OKAMOTO ; Daisuke AOKI ; Sokbom KANG ; Jeong-Won LEE ; Jae-Weon KIM ; Jae-Hoon KIM ; Zhongqiu LIN ; Jihong LIN ; Xiaohua WU ; Hung-Cheng LAI ; Ting-Chang CHANG ; Chyong-Huey LAI ; Yong Man KIM ; Takayuki ENOMOTO
Journal of Gynecologic Oncology 2024;35(3):e87-
Ovarian cancer, notable for its severe prognosis among gynecologic cancers, has seen substantial progress in treatment approaches recently. Enhanced protocols in chemotherapy and the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors for maintenance therapy have markedly improved outcomes for patients with specific genetic profiles, such as those positive for BRCA mutations or exhibiting homologous recombination deficiency (HRD). Additionally, the method of intraperitoneal chemotherapy administration has emerged as a valuable alternative to traditional transvenous routes, showing promise for wider clinical adoption. The field of surgery has also evolved, with increasing exploration into the benefits and feasibility of laparoscopic methods over more invasive traditional surgeries, aiming for complete tumor removal but with reduced patient impact. The hereditary nature of ovarian cancer underscores the importance of genetic testing, which has become integral in tailoring treatment strategies, particularly in determining suitability for PARP inhibitors.The formation of the East Asian Gynecologic Oncology Trial Group (EAGOT) aims to optimize treatment across Japan, Korea, China, and Taiwan. The ovarian cancer committee of EAGOT shared the current policies, focusing on 5 topics: 1) strategies for maintenance therapy after initial surgery and chemotherapy, 2) drug regimens for platinum-sensitive and platinum-resistant recurrence, 3) intraperitoneal chemotherapy, 4) laparoscopic surgery as an alternative to laparotomy, and 5) current status of genetic testing (BRCA, HRD, and panel tests) for ovarian cancer and its prospects. EAGOT’s multi-national trials aim to harmonize these evolving treatment strategies, ensuring that the latest and most effective protocols are accessible across the region, thereby significantly impacting patient outcomes in East Asia.
8.Impact of adjuvant treatment on survival in patients with 2023 FIGO stage IIC endometrial cancer: a retrospective analysis from two tertiary centers in Korea and Taiwan
Yoo-Young LEE ; Yen-Ling LAI ; Myeong-Seon KIM ; Koping CHANG ; Hyun-Soo KIM ; Wen-Fang CHENG ; Yu-Li CHEN
Journal of Gynecologic Oncology 2024;35(3):e33-
Objective:
In early-stage endometrial cancer, aggressive histologic types (grade 3 endometrioid, serous, clear cell, carcinosarcomas, undifferentiated, mixed, and other unusual types) are associated with an increased risk of distant metastases and worse survival. However, the optimal adjuvant treatment for these patients remains controversial. The present study investigated the outcomes of different adjuvant treatments in patients with 2023 FIGO stage IIC endometrial cancer.
Methods:
We retrospectively identified patients with 2023 FIGO stage IIC endometrial cancer who underwent surgery followed by either adjuvant treatment or observation from 2000 to 2020 at two tertiary centers in Korea and Taiwan. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Kaplan-Meier estimates and Cox proportional-hazards models. We also analyzed recurrence patterns after different adjuvant treatments.
Results:
A total of 272 patients were identified; 204 received adjuvant treatment postoperatively, whereas 68 only underwent observation. Adjuvant treatment was not associated with improved RFS or OS. Non-endometrioid histologic types (p=0.003) and presence of lymphovascular space invasion (LVSI, p=0.002) were associated with worse RFS, whereas only non-endometrioid histologic types impacted OS (p=0.004). In subgroup analyses, adjuvant treatment improved OS in patients with LVSI (p=0.020) and in patients with both LVSI and grade 3 endometrioid histologic type (p=0.007). We found no difference in locoregional and distant recurrence between patients undergoing adjuvant treatment or observation.
Conclusion
In this study, the addition of adjuvant treatment was associated with an OS benefit for patients with LVSI, especially those with grade 3 endometrioid tumors.
9.Current treatment strategies for ovarian cancer in the East Asian Gynecologic Oncology Trial Group (EAGOT)
Yusuke KOBAYASHI ; Muneaki SHIMADA ; Masato TAMATE ; Hyun Woong CHO ; Jun ZHU ; Hung-Hsueh CHOU ; Hiroaki KAJIYAMA ; Aikou OKAMOTO ; Daisuke AOKI ; Sokbom KANG ; Jeong-Won LEE ; Jae-Weon KIM ; Jae-Hoon KIM ; Zhongqiu LIN ; Jihong LIN ; Xiaohua WU ; Hung-Cheng LAI ; Ting-Chang CHANG ; Chyong-Huey LAI ; Yong Man KIM ; Takayuki ENOMOTO
Journal of Gynecologic Oncology 2024;35(3):e87-
Ovarian cancer, notable for its severe prognosis among gynecologic cancers, has seen substantial progress in treatment approaches recently. Enhanced protocols in chemotherapy and the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors for maintenance therapy have markedly improved outcomes for patients with specific genetic profiles, such as those positive for BRCA mutations or exhibiting homologous recombination deficiency (HRD). Additionally, the method of intraperitoneal chemotherapy administration has emerged as a valuable alternative to traditional transvenous routes, showing promise for wider clinical adoption. The field of surgery has also evolved, with increasing exploration into the benefits and feasibility of laparoscopic methods over more invasive traditional surgeries, aiming for complete tumor removal but with reduced patient impact. The hereditary nature of ovarian cancer underscores the importance of genetic testing, which has become integral in tailoring treatment strategies, particularly in determining suitability for PARP inhibitors.The formation of the East Asian Gynecologic Oncology Trial Group (EAGOT) aims to optimize treatment across Japan, Korea, China, and Taiwan. The ovarian cancer committee of EAGOT shared the current policies, focusing on 5 topics: 1) strategies for maintenance therapy after initial surgery and chemotherapy, 2) drug regimens for platinum-sensitive and platinum-resistant recurrence, 3) intraperitoneal chemotherapy, 4) laparoscopic surgery as an alternative to laparotomy, and 5) current status of genetic testing (BRCA, HRD, and panel tests) for ovarian cancer and its prospects. EAGOT’s multi-national trials aim to harmonize these evolving treatment strategies, ensuring that the latest and most effective protocols are accessible across the region, thereby significantly impacting patient outcomes in East Asia.
10.Impact of adjuvant treatment on survival in patients with 2023 FIGO stage IIC endometrial cancer: a retrospective analysis from two tertiary centers in Korea and Taiwan
Yoo-Young LEE ; Yen-Ling LAI ; Myeong-Seon KIM ; Koping CHANG ; Hyun-Soo KIM ; Wen-Fang CHENG ; Yu-Li CHEN
Journal of Gynecologic Oncology 2024;35(3):e33-
Objective:
In early-stage endometrial cancer, aggressive histologic types (grade 3 endometrioid, serous, clear cell, carcinosarcomas, undifferentiated, mixed, and other unusual types) are associated with an increased risk of distant metastases and worse survival. However, the optimal adjuvant treatment for these patients remains controversial. The present study investigated the outcomes of different adjuvant treatments in patients with 2023 FIGO stage IIC endometrial cancer.
Methods:
We retrospectively identified patients with 2023 FIGO stage IIC endometrial cancer who underwent surgery followed by either adjuvant treatment or observation from 2000 to 2020 at two tertiary centers in Korea and Taiwan. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Kaplan-Meier estimates and Cox proportional-hazards models. We also analyzed recurrence patterns after different adjuvant treatments.
Results:
A total of 272 patients were identified; 204 received adjuvant treatment postoperatively, whereas 68 only underwent observation. Adjuvant treatment was not associated with improved RFS or OS. Non-endometrioid histologic types (p=0.003) and presence of lymphovascular space invasion (LVSI, p=0.002) were associated with worse RFS, whereas only non-endometrioid histologic types impacted OS (p=0.004). In subgroup analyses, adjuvant treatment improved OS in patients with LVSI (p=0.020) and in patients with both LVSI and grade 3 endometrioid histologic type (p=0.007). We found no difference in locoregional and distant recurrence between patients undergoing adjuvant treatment or observation.
Conclusion
In this study, the addition of adjuvant treatment was associated with an OS benefit for patients with LVSI, especially those with grade 3 endometrioid tumors.

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