Objective To investigate the effect of isosorbide mononitrate tablets in conjunction with contin-uous renal replacement therapy(CRRT)on renal and cardiac function in uremia patients complicated with chronic heart failure(CHF).Methods A total of 120 in uremia patients complicated with CHF admitted to this hospital from May 2020 and July 2022 were selected as the research subjects.According to the treatment plan,they were divided into the observation group(62 cases)and the control group(58 cases).The control group was treated with CRRT,while the observation group was treated with isosorbide mononitrate tablets on the basis of the control group.The treatment course for both groups was 4 weeks.The clinical efficacy of the two groups of patients after treatment,the changes in renal function,cardiac function before and after treat-ment,as well as the levels of serum creatinine(Scr),and N-terminal pro-brain natriuretic peptide(NT-proB-NP)were observed and compared.The adverse reactions during the treatment period was recorded.Results The total clinical effective rate of the observation group was higher than that of the control group(P＜0.05).The levels of blood urea nitrogen(BUN),left ventricular end-diastolic diameter(LVED),heart rate(HR),mean arterial pressure(MAP),sST2,and NT-proBNP after treatment in both groups decreased compared with those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P＜0.05).The hemoglobin(Hb),albumin(ALB),left ventricular e-jection fraction(LVEF),and six-minute walk distance(6MWD)in both groups NT-proBNP increased and the levels in the observation group were higher than those in the control group,and the differences were statisti-cally significant(P＜0.05).The total incidence of adverse reactions in the observation group was slightly low-er than that in the control group,but the difference was not statistically significant(P＞0.05).Conclusion The ther-apeutic regimen of isosorbide mononitrate tablets combined with CRRT can significantly improve the renal and cardiac functions of patients with uremia complicated with CHF,reduce the levels of serum sST2 and NT-proBNP,and it has few adverse reactions and good safety.