Objective: This study was performed to evaluate the efficacy and safety of lurasidone (160 mg/day) compared to quetiapine XR (QXR; 600 mg/day) in the treatment of acutely psychotic patients with schizophrenia. Methods: Patients were randomly assigned to 6 weeks of double-blind treatment with lurasidone 160 mg/day (n=105) or QXR 600 mg/day (n=105). Primary efficacy measure was the change from baseline to week 6 in Positive and Negative Syndrome Scale (PANSS) total score and Clinical Global Impressions severity (CGI-S) score. Adverse events, body measurements, and laboratory parameters were assessed. Results: Lurasidone demonstrated non-inferiority to QXR on the PANSS total score. Adjusted mean±standard error change at week 6 on the PANSS total score was -26.42±2.02 and -27.33±2.01 in the lurasidone and QXR group, respectively. The mean difference score was -0.91 (95% confidence interval -6.35–4.53). The lurasidone group showed a greater reduction in PANSS total and negative subscale on week 1 and a greater reduction in end-point CGI-S score compared to the QXR group. Body weight, body mass index, and waist circumference in the lurasidone group were reduced, with significantly lower mean change compared to QXR. Endpoint changes in glucose, cholesterol, triglycerides, and low-density lipoprotein levels were also significantly lower. The most common adverse drug reactions with lurasidone were akathisia and nausea. Conclusion Lurasidone 160 mg/day was found to be non-inferior to QXR 600 mg/day in the treatment of schizophrenia with comparable efficacy and tolerability. Adverse effects of lurasidone were generally tolerable, and beneficial effects on metabolic parameters can be expected.

OBJECTIVE: This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders. METHODS: Inclusion criteria were as follows: age >20 years, diagnosis of anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria, taking only one type of antidepressant, and prescribed one of three oral benzodiazepines (alprazolam, clonazepam, or lorazepam). At baseline and week 6, clinical benefit was evaluated using the Clinical Global Impression-Severity Scale (CGI-S), Clinical Global Impression-Anxiety Scale (CGI-anxiety), and Clinical Global Impression-Sleep Scale (CGI-sleep). RESULTS: Among 180 patients, no differences in demographic characteristics among the three benzodiazepine groups were noted. After six weeks of treatment, all benzodiazepine groups showed significant improvements in CGI-S, CGI-anxiety, and CGI-sleep scores (p<0.001). There were no differences in mean changes in CGI-S, CGI-anxiety and CGI-sleep among the three benzodiazepine groups. The incidence of side effects was significantly lower in the clonazepam group than with the other benzodiazepines. The incidences of adverse events for the clonazepam, alprazolam, and lorazepam groups were 26.7% (n=20), 48.4% (n=31), and 43.9% (n=18), respectively. CONCLUSION: The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders. Furthermore, the safety profile of clonazepam was superior to the other benzodiazepines in this study.
Alprazolam ; Anti-Anxiety Agents ; Antidepressive Agents* ; Anxiety Disorders* ; Anxiety* ; Benzodiazepines ; Clonazepam* ; Diagnosis ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Incidence ; Lorazepam

There are many causes of prolonged postoperative muscle weakness, including drugs, residual anesthetics, cerebrovascular events, electrolyte imbalance, hypothermia, and neuromuscular disease. Neuromuscular diseases are relatively rare, with the most common being myasthenia gravis and Lambert-Eaton myasthenic syndrome (LEMS). We report an unusual case in which a patient who was given a muscle relaxant during mediastinoscopy developed postoperative muscle weakness that was ultimately diagnosed as secondary to LEMS.
Anesthetics ; Humans ; Hypothermia ; Lambert-Eaton Myasthenic Syndrome ; Mediastinoscopy ; Muscle Weakness ; Muscles ; Myasthenia Gravis ; Neuromuscular Diseases

BACKGROUND: Gastrointestinal bowel movements are reduced by opioid-based anesthesia. Remifentanil is commonly used as total intravenous anesthesia. This study compared to the effect of various anesthetic methods on gastrointestinal bowel movement after colon surgery. METHODS: Ninety patients were allocated randomly into three groups. Thirty patients received intraoperative inhalation anesthesia (desflurane + N2O, Group I), 30 patients received intraoperative total intravenous anesthesia (propofol + remifentanil, Group II), and 30 patients received intraoperative epidural anesthesia (epidural lidocaine + propofol, Group III). All patients received postoperative epidural analgesia with a mixture of ropivacaine and morphine. The time to the first passage of flatus, hospital stay and visual analog pain scale were recorded. RESULTS: There was no significant difference in first passage of flatus among groups (Group I: 92.7 +/- 19.6, Group II: 86.9 +/- 19.4, Group III: 81.9 +/- 12.8 hours, P = 0.063). There were no significant difference in the hospital stay and visual analog scale among the three groups. CONCLUSIONS: Total intravenous anesthesia with remifentanil did not reduce the gastrointestinal bowel movements compared with those of inhalation or epidural anesthesia.
Analgesia, Epidural ; Anesthesia ; Anesthesia, Epidural ; Anesthesia, Inhalation ; Anesthesia, Intravenous ; Colon* ; Flatulence ; Humans ; Inhalation ; Length of Stay ; Lidocaine ; Morphine ; Pain Measurement ; Propofol ; Visual Analog Scale

Foreign body ingestion induces various complications during the induction of and emergence from anesthesia. These complications include inconsequential mucosal scratches, abrasion, laceration, esophageal stricture, necrosis, retropharyngeal abscess formation, hemorrhage, obstruction and perforation. We experienced a case of esophageal perforation after ingestion of a dental prosthesis during emergence. A 71-year-old female patient received general anesthesia for a lumbar laminectomy. At postanesthesia care unit, she complained of a sore throat and found that her dental prosthesis was missing. The impacted dental prosthesis was found at the T7 level, which was followed due to its perforation through the esophageal wall, causing mediastinitis. She underwent an operation for the esophageal repair and was discharged with slight chest discomfort due to operation, after 10 days.
Aged ; Anesthesia ; Anesthesia, General* ; Dental Prosthesis* ; Eating ; Esophageal Perforation* ; Esophageal Stenosis ; Female ; Foreign Bodies ; Hemorrhage ; Humans ; Lacerations ; Laminectomy ; Mediastinitis ; Necrosis ; Pharyngitis ; Retropharyngeal Abscess ; Thorax

Foreign body ingestion induces various complications during the induction of and emergence from anesthesia. These complications include inconsequential mucosal scratches, abrasion, laceration, esophageal stricture, necrosis, retropharyngeal abscess formation, hemorrhage, obstruction and perforation. We experienced a case of esophageal perforation after ingestion of a dental prosthesis during emergence. A 71-year-old female patient received general anesthesia for a lumbar laminectomy. At postanesthesia care unit, she complained of a sore throat and found that her dental prosthesis was missing. The impacted dental prosthesis was found at the T7 level, which was followed due to its perforation through the esophageal wall, causing mediastinitis. She underwent an operation for the esophageal repair and was discharged with slight chest discomfort due to operation, after 10 days.
Aged ; Anesthesia ; Anesthesia, General* ; Dental Prosthesis* ; Eating ; Esophageal Perforation* ; Esophageal Stenosis ; Female ; Foreign Bodies ; Hemorrhage ; Humans ; Lacerations ; Laminectomy ; Mediastinitis ; Necrosis ; Pharyngitis ; Retropharyngeal Abscess ; Thorax

BACKGROUND AND OBJECTIVES: The ventricular activation time (VAT) is increased in both ventricular hypertrophy and bundle branch block. It is also known that the VAT is increased in myocardial ischemia due to the development of depolarization abnormality. However, little is known about the changes in the VAT on body surface electrocardiography following coronary stenting in patients with ischemic heart disease. The purpose of this study was to evaluate the clinical significance of VAT following coronary stenting by assessing the changes in the VAT during the 6 months following coronary stenting in patients with ischemic heart disease. SUBJECTS AND METHODS: The VAT was measured in 92 patients who had underdone coronary stenting due to of significant coronary artery stenosis on coronary angiography. The electrocardiography was recorded with a high paper speed at pre-stenting, immediate after and at 1 and 6 months after coronary stenting. RESULTS: The VAT was significantly decreased during the 6 month follow-up following coronary stenting (pre-stenting ; 45.9 +/-5.9 msec, immediate after stenting ; 38.5+/-2.7 msec, after 1 month ; 38.8+/-2.8 msec and after 6 months ; 38.8+/-2.5 msec, p<0.05). The VAT dispersion was significantly decreased during the 6 month follow-up following coronary stenting in the patients with one vessel disease (p<0.05), but not with two vessels disease. CONCLUSION: Coronary stenting significantly decreased the VAT during the 6 month follow-up. We would conclude that coronary stenting relieves depolarization abnormalities caused by myocardial ischemia, and improves the intraventricular conduction velocity. However, further studies are needed to assess the usefulness of VAT in evaluating myocardial ischemia.
Bundle-Branch Block ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Disease ; Coronary Stenosis ; Coronary Vessels* ; Electrocardiography ; Follow-Up Studies ; Humans ; Hypertrophy ; Myocardial Ischemia ; Stents*

BACKGROUND: The relative frequency and clinicopathologic characteristics of lymphomas vary according to geography and race. Data on the features of cutaneous lymphoma in Korea are limited. OBJECTIVE: The aim of this study was to document the relative occurrence, the clinical and histopathological features of cutaneous lymphomas in Korea. METHODS: The Korean Dermatopathology Research Group conducted a review of nationwide collection of 80 cutaneous lymphomas, diagnosed at 23 institutes over recent 3-year period. Clinical records and pathology slides of the patients were reviewed retrospectively. RESULTS AND CONCLUSION: Korea has a higher rate of T-cell lymphoma and NK/T cell lymphoma and a much lower rate of cutaneous B cell lymphoma. The relative frequency of the major diagnostic group according to WHO classification was as follows: mycosis fungoides/Sezary syndrome, 42.5%; anaplastic large cell lymphoma, 19%; nasal and nasal type NK/T cell lymphoma, 15%; subcutaneous panniculitis-like T cell lymphoma, 11%; peripheral T cell lymphoma, unspecified, 7.5%; follicular lymphoma, 3%; marginal zone lymphoma, 1%; angioimmunoblastic lymphadenopathy, 1%. Compared with Western countries, the rate of nasal and nasal-type NK/T cell lymphoma and subcutaneous panniculitis-like T cell lymphoma were much higher. Therefore, The EORTC classification is not effective in dealing with Korean cases of cutaneous lymphoma. We consider the principles of the WHO classification are applicable to the Korean cases of cutaneous lymphoma.
Academies and Institutes ; Classification ; Continental Population Groups ; Geography ; Humans ; Immunoblastic Lymphadenopathy ; Korea* ; Lymphoma* ; Lymphoma, B-Cell ; Lymphoma, Follicular ; Lymphoma, Large-Cell, Anaplastic ; Lymphoma, T-Cell ; Lymphoma, T-Cell, Peripheral ; Pathology ; Retrospective Studies

BACKGROUND: Malignant melanoma in Korea has been increasing as in other countries, but there is no nationwide survey of malignant melanoma in Korea. OBJECTIVE: The aim of this study was to document the clinical and histopathological features of cutaneous melanoma in Korea. METHODS: The Dermatopathology Research Group conducted a review of nationwide collection of 109 primary cutaneous melanomas, diagnosed at 23 institutes over a recent 3-year period. Clinical records and pathology slides of the patients were reviewed retrospectively. RESULTS AND CONCLUSION: The peak age was the 7th decade with the mean age of 58.1 years. Korea has a higher rate of acral melanoma and much lower rate of lentigo maligna melanoma. .Major component tumor cell was spindle cell type. Clark level of tumor was III or more and Breslow depth was 2mm or more at the time of the first diagnosis in many cases (62%). Pre-existing melanocytic nevus was present in a few cases (3 cases). All these features suggest that the racial difference between the Korean and the Caucasian is evident. We also suggest that an early detection program is very important to cure this malignant tumor.
Academies and Institutes ; Diagnosis ; Humans ; Hutchinson's Melanotic Freckle ; Korea* ; Melanoma* ; Nevus, Pigmented ; Pathology ; Retrospective Studies

Moyamoya disease is an unusual cerebrovascular disorder characterized by occlusive intimal dysplasia of the distal internal carotid and proximal cerebral arteries, but the etiology remains unclear. Angiographic characteristics include bilateral stenosis or occlusion of the terminal portions of the intracranial internal carotid arteries and bilateral development of fine collateral vessels at the base of the brain known as 'Moyamoya vessels'. Cardiac surgery using cardiopulmonary bypass due to coronary artery disease and others among patients with moyamoya disease is very rare, and cardiac surgery for such patients has a potential risk of intraoperative and perioperative brain ischemia. We successfully treated a patient who underwent artrial septal defect closure and coronary artery bypass graft using the cardiopulmonary bypass, so we report this case with a brief literature review.
Brain ; Brain Ischemia ; Cardiopulmonary Bypass ; Carotid Artery, Internal ; Cerebral Arteries ; Cerebrovascular Disorders ; Constriction, Pathologic ; Coronary Artery Bypass ; Coronary Artery Disease ; Humans ; Moyamoya Disease* ; Thoracic Surgery* ; Transplants