Objective:To analyze and summarize the operational mechanisms of the " National Facility for Translational Medicine (Shanghai)" (referred to as the Shanghai Facility), providing reference for the high-quality construction, management, and utilization of such facilities.Methods:Using the construction and operation of the Shanghai facility as a case study, this paper analyzed and discussed the facility's construction content, functional positioning, operational management systems, operational outcomes, in the meanwhile summarizing experience in construction and running of the facility.Results:Since the Shanghai facility was completed and officially put into operation in December 2020, significant achievements had been made in platform construction and operation.Conclusions:The successful operation of the Shanghai facility provides valuable experience for the construction of national major scientific and technological infrastructure in the field of translational medicine. In the future, its construction and management can be further improved through measures such as multi-channel fundraising, building-up of a multidisciplinary translational medicine talent team, and establishment of reasonable facility assessment criteria and talent evaluation standards.

Objective:To analyze and summarize the operational mechanisms of the " National Facility for Translational Medicine (Shanghai)" (referred to as the Shanghai Facility), providing reference for the high-quality construction, management, and utilization of such facilities.Methods:Using the construction and operation of the Shanghai facility as a case study, this paper analyzed and discussed the facility's construction content, functional positioning, operational management systems, operational outcomes, in the meanwhile summarizing experience in construction and running of the facility.Results:Since the Shanghai facility was completed and officially put into operation in December 2020, significant achievements had been made in platform construction and operation.Conclusions:The successful operation of the Shanghai facility provides valuable experience for the construction of national major scientific and technological infrastructure in the field of translational medicine. In the future, its construction and management can be further improved through measures such as multi-channel fundraising, building-up of a multidisciplinary translational medicine talent team, and establishment of reasonable facility assessment criteria and talent evaluation standards.

Objective To investigate the impact of statistical uncertainty per control point(SUpCP)on dose calculation on volumetric modulated arc therapy(VMAT)for rectum cancer,and to analyze the accuracy and efficiency of calculation.Methods 19 patients with rectum cancer undergoing radiotherapy were selected.The initial VMAT plans were generated on Monaco TPS using SUpCP=3,then changed SUpCP in the dose calculation process as follow:10 SUpCPs(1～10)for each patient,and totally190 VMAT dose distributions were obtained.For plan evaluation,Dmax,Dmean,D95%,V50,homogeneity index(HI),conformity index(CI)of the planning target volume(PTV),dissymmetric variations of bladder,small intestine and femoral head,and time calculation(Time)were analyzed.Patient specific quality assurance(PSQA),dose deviation of isocenter(ΔDISO)and passing rate of three-dimensional dose distribution(γ33,γ32,γ22)between calculated and delivered radiation doses were measured.Results AsSUpC increased,Dmax and HI of PTV,Dmax of bladder were increased,but D95%and V50 of PTV,Time,γ32 and γ22 were decreased(P<0.05).Dmax and CI of PTV,Dmean of bladder,Dmax and Dmean of small intestine and femoral head,ΔDISO and γ33 showed no statistical significance(P>0.05).When ΔDISO<1%,gamma passing rate>90%for all VMAT plan.When SUpCP<6,Dmax of PTV<110%of the prescribed dose was obtained;while SUpCP>2,time for dose calculation was less than 5 min.Conclusion For VMAT plan of rectum cancer on Monaco TPS using XVMC algorithm,3%～5%of statistical uncertainty per control point for dose calculation,and 3%2 mm or 2%2 mm gamma criteria for three-dimensional dose verification is recommended.This study provides clinical application basis for precise dose calculation of VMAT plan of rectum cancer.

Objective:Based on an exploratory case study of the National Major Science and Technology Infrastructure for Translational Medicine (Shanghai), this study aims to investigate the current development status of the construction and governance of the achievement transformation system in China′s new research and development institutions, explore the tools and means to improve the efficiency of scientific and technological achievement transformation in the biopharmaceutical field, and explore effective ways for medical institutions to promote scientific and technological achievement transformation in the biopharmaceutical achievement transformation chain.Methods:By reviewing the policies and regulations issued by national and local departments in recent years, and reviewing literature and real cases related to the transformation of scientific and technological achievements in medical institutions in the past five years, an analysis was conducted.Results:Based on an exploratory case study of the National Major Science and Technology Infrastructure for Translational Medicine (Shanghai), strategies and suggestions were proposed to promote the transformation of scientific and technological achievements in new research and development institutions.Conclusions:A scientific research and development and verification platform mainly based on large scientific facilities, through the establishment of a professional transfer office team, is more conducive to the construction and governance of a hospital park close transformation model of scientific and technological achievements, promoting the two-way integration and development of the biopharmaceutical industry and medical institutions, and promoting the rapid marketization of medical scientific and technological achievements.

Objective:Based on an exploratory case study of the National Major Science and Technology Infrastructure for Translational Medicine (Shanghai), this study aims to investigate the current development status of the construction and governance of the achievement transformation system in China′s new research and development institutions, explore the tools and means to improve the efficiency of scientific and technological achievement transformation in the biopharmaceutical field, and explore effective ways for medical institutions to promote scientific and technological achievement transformation in the biopharmaceutical achievement transformation chain.Methods:By reviewing the policies and regulations issued by national and local departments in recent years, and reviewing literature and real cases related to the transformation of scientific and technological achievements in medical institutions in the past five years, an analysis was conducted.Results:Based on an exploratory case study of the National Major Science and Technology Infrastructure for Translational Medicine (Shanghai), strategies and suggestions were proposed to promote the transformation of scientific and technological achievements in new research and development institutions.Conclusions:A scientific research and development and verification platform mainly based on large scientific facilities, through the establishment of a professional transfer office team, is more conducive to the construction and governance of a hospital park close transformation model of scientific and technological achievements, promoting the two-way integration and development of the biopharmaceutical industry and medical institutions, and promoting the rapid marketization of medical scientific and technological achievements.