Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis is a special type of dermatomyositis. It has characteristic clinical manifestations, mild myositis symptoms, and is prone to be accompanied by rapidly progressive interstitial lung disease, which indicates a poor prognosis. Its pathogenesis remains unclear, and may be related to genetic and environmental factors. This review summarizes progress in the treatment of anti-MDA5 antibody-positive dermatomyositis in recent years, in order to provide new ideas for its clinical treatment.

Objective This study aims to explore the effectiveness of constructing a performance management system that integrates business and financial aspects based on the RBRVS concept in a public tertiary hospital.Methods The study selected seven departments in a public tertiary hospital,including Oral and Maxillofacial Surgery,Rehabilitation Medicine,General Sur-gery and Gastrointestinal Surgery,Obstetrics,Gynecology,General Surgery of Hepatobiliary Pancreatic and Breast,and Neuro-surgery.A comparative analysis of performance management was conducted between the control group(January to June 2023)and the observation group(January to June 2024).The control group used traditional performance management methods,while the observation group implemented a new performance management strategy based on the RBRVS concept and the integration of business and financial aspects.Results Compared to the control group,the observation group showed lower values in terms of average outpatient cost,average inpatient cost,cost of consumables per 100 yuan of revenue,and proportion of inpatient drug costs.Additionally,the observation group performed better than the control group in terms of the proportion of medical service in-come and management quality,with statistically significant differences(P＜0.05).Conclusion The performance management system based on the integration of RBRVS concept and financial management plays a significant role in increasing the proportion of medical service income and reducing medical costs.Furthermore,this system improves the reliability and rationality of manage-ment,focuses more on humanized management,significantly enhances management quality,and has important reference value for clinical practice.

Objective This study aims to explore the effectiveness of constructing a performance management system that integrates business and financial aspects based on the RBRVS concept in a public tertiary hospital.Methods The study selected seven departments in a public tertiary hospital,including Oral and Maxillofacial Surgery,Rehabilitation Medicine,General Sur-gery and Gastrointestinal Surgery,Obstetrics,Gynecology,General Surgery of Hepatobiliary Pancreatic and Breast,and Neuro-surgery.A comparative analysis of performance management was conducted between the control group(January to June 2023)and the observation group(January to June 2024).The control group used traditional performance management methods,while the observation group implemented a new performance management strategy based on the RBRVS concept and the integration of business and financial aspects.Results Compared to the control group,the observation group showed lower values in terms of average outpatient cost,average inpatient cost,cost of consumables per 100 yuan of revenue,and proportion of inpatient drug costs.Additionally,the observation group performed better than the control group in terms of the proportion of medical service in-come and management quality,with statistically significant differences(P＜0.05).Conclusion The performance management system based on the integration of RBRVS concept and financial management plays a significant role in increasing the proportion of medical service income and reducing medical costs.Furthermore,this system improves the reliability and rationality of manage-ment,focuses more on humanized management,significantly enhances management quality,and has important reference value for clinical practice.

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis is a special type of dermatomyositis. It has characteristic clinical manifestations, mild myositis symptoms, and is prone to be accompanied by rapidly progressive interstitial lung disease, which indicates a poor prognosis. Its pathogenesis remains unclear, and may be related to genetic and environmental factors. This review summarizes progress in the treatment of anti-MDA5 antibody-positive dermatomyositis in recent years, in order to provide new ideas for its clinical treatment.

Background::Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early childhood. This study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in China.Methods::We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies. A healthy parental lifestyle score (ranged 0-5) was constructed based on the following five modifiable lifestyle factors: Smoking, drinking, exercise, sleep, and diet. Generalized estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years (2012, 2014, 2016, and 2018).Results::Offspring in the top tertile of parental healthy lifestyle scores performed better in overall fluid intelligence (multivariable-adjusted β = 0.53, 95% confidence interval [CI]: 0.29-0.77) and overall crystallized intelligence (multivariable-adjusted β = 0.35, 95% CI: 0.16-0.54) than those in the bottom tertile of parental healthy lifestyle scores. The results were similar after further adjustment for the offspring’s healthy lifestyle scores and persisted across the subgroups of parental socioeconomic status. Additionally, maternal and paternal healthy lifestyle scores were independently associated with better offspring’s cognitive performance, with significant contribution observed for paternal never-smoking, weekly exercise, and diversified diet. When both parents and offspring adhered to a healthier lifestyle, we observed the highest level of the offspring’s overall crystallized intelligence. Conclusions::Our study indicates that parental adherence to a healthier lifestyle is associated with significantly better offspring’s cognitive performance during adolescence and early adulthood, regardless of socioeconomic status. These findings highlight the potential cognitive benefits of promoting healthy lifestyles among parents of adolescents.

Gastric cancer ranks fifth in global cancer mortality,which is highly aggressive and heterogeneous.How-ever,the research and treatment of gastric cancer is hindered by short of research models that may characterize the developmental properties of gastric cancer.Gastric cancer organoid is a multicellular three-dimensional structure de-veloped in vitro,which can mimic the structure and function of native gastric cancer.Gastric cancer organoids have great application potential and development prospects in establishing gastric cancer research models,mimicking the tumor microenvironment,high-throughput screening of drugs,discovering new therapeutic targets,predicting clinical therapeutic responses,and guiding individualized treatment.In this paper,the progress of gastric cancer or-ganoids in basic research and clinical application is reviewed aiming for promoting the progress of preclinical re-search and supporting the clinical treatment of gastric cancer.

Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare disease characterized by multiple non-specific superficial ulcers in the small intestine, for which there is a lack of effective medical treatment. Loss-of-function mutations in the SLCO2A1 gene contribute to the onset of CEAS. However, the downstream target cell and molecular mechanisms of the gene mutation still require further investigation. In this article, we comprehensively review recent findings regarding the pathogenesis of CEAS, encompassing five aspects: PGE2 metabolic disorder, immunology, endothelial dysfunction, Maxi-Cl channel, and epigenetics, while also presenting future prospects and outlook.

Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare disease characterized by multiple non-specific superficial ulcers in the small intestine, for which there is a lack of effective medical treatment. Loss-of-function mutations in the SLCO2A1 gene contribute to the onset of CEAS. However, the downstream target cell and molecular mechanisms of the gene mutation still require further investigation. In this article, we comprehensively review recent findings regarding the pathogenesis of CEAS, encompassing five aspects: PGE2 metabolic disorder, immunology, endothelial dysfunction, Maxi-Cl channel, and epigenetics, while also presenting future prospects and outlook.

Humans ; Asthma/drug therapy* ; Biological Therapy

N 6-methyladenosine (m 6A) modification can regulate gene expression by influencing RNA stability, nuclear transport, translation efficiency, alternative splicing and degradation. Current studies have shown that m 6A modification is associated with multiple biological behaviors of melanoma, such as proliferation, metastasis and resistance to immunotherapy, but specific mechanisms still need further study. This review summarizes the regulation of m 6A RNA methylation, and its related biological behaviors and mechanisms of action in melanoma.