Trauma can disrupt the body′s internal environment, resulting in organ dysfunction. This may manifest as symptoms such as acute respiratory distress, liver and kidney dysfunction, circulatory disorders and neurological damage. Mitochondrial quality control (MQC), encompassing processes like autophagy, dynamic changes, and biogenesis, plays an essential role in maintaining mitochondrial function. Stress responses following trauma can cause mitochondrial dysfunction and MQC imbalance, thereby exacerbating organ injury. Correcting MQC imbalance can improve organ function. Current researches on MQC in post-traumatic organ dysfunction mainly focuses on imbalance in specific MQC mechanism, lacking a systemic understanding of its incidence and progression. To this end, the authors reviewed the progress in researches on the impact of MQC imbalance on post-traumatic organ dysfunction, aiming to provide insights for clinical treatment.

Trauma can disrupt the body′s internal environment, resulting in organ dysfunction. This may manifest as symptoms such as acute respiratory distress, liver and kidney dysfunction, circulatory disorders and neurological damage. Mitochondrial quality control (MQC), encompassing processes like autophagy, dynamic changes, and biogenesis, plays an essential role in maintaining mitochondrial function. Stress responses following trauma can cause mitochondrial dysfunction and MQC imbalance, thereby exacerbating organ injury. Correcting MQC imbalance can improve organ function. Current researches on MQC in post-traumatic organ dysfunction mainly focuses on imbalance in specific MQC mechanism, lacking a systemic understanding of its incidence and progression. To this end, the authors reviewed the progress in researches on the impact of MQC imbalance on post-traumatic organ dysfunction, aiming to provide insights for clinical treatment.

This study aims to explore the potential of polyaspartic acid grafted dopamine copolymer (PAsp- g-DA) chelated Fe ³⁺ for magnetic resonance imaging (MRI) visual photothermal therapy. Polyaspartic acid grafted copolymer of covalently grafted dopamine and polyethylene glycol (PAsp- g-DA/PEG) was obtained by the ammonolysis reaction of poly succinimide (PSI), and then chelated with Fe ³⁺ in aqueous solution. The relaxivity in vitro, magnetic resonance imaging enhancement in vivo and photothermal conversion effect at 808 nm were investigated. The results showed that polymeric iron coordination had good near-infrared absorption and photothermal conversion properties, good magnetic resonance enhancement effect, and good longitudinal relaxation efficiency under different magnetic field intensities. In summary, this study provides a new magnetic resonance visual photothermal therapeutic agent and a new research idea for the research in related fields.
Dopamine ; Magnetic Resonance Imaging/methods* ; Nanoparticles ; Peptides ; Phototherapy ; Photothermal Therapy ; Polymers

Objective To investigate the effect of Reduning injection(RI)on international normalized ratio(INR) ,prothrombin time(PT)and activated partial thromboplastin time(APTT)levels in patients with Trimeresurus stejnegeri(TS)bite .Methods Three hundred cases of patients with TS bite in our hospital from July 2010 to July 2013 were randomly divided into 2 groups .The control group received the routine treatment while the observation group treated with RI besides ,and then compared the growth of symptoms ,effect and changes of INR ,PT and APTT of 2 groups .Results The observation group′s swelling time [(127 .8 ± 56 .2) h] ,analgesic time [(5 .3 ± 2 .7)h] ,hospitalization time [(3 .8 ± 2 .7)d] was lower than those of the control group[ (150 .3 ± 83 .4) h ,(11 .5 ± 6 .1)h ,(5 .8 ± 4 .4)d] .The INR ,PT and APTT of 2 groups after treatment were both extended .However ,the extended degree of observation group was much lower .The observation group′s cure rate [90 .00% (135/150)] ,markedly effective rate [98 .00% (147/150)]were higher than those of the control group [67 .33% (101/150) ,84 .67% (127/150)] ,which showed statisti‐cally significant difference(P<0 .05) .Conclusion RI shows good effect on curing TS bite patients and could effectively shorten the time for symptom improvement and inhibit the prolonged coagulation index .