Objective:To evaluate the effect of value orientation brief therapy(VBT)combined with selective serotonin reuptake inhibitors(SSRIs)on clinical symptoms,rumination,decision-making ability,and cognitive func-tion in patients with mild to moderate depression.Methods:Eighty patients meeting the DSM-5 diagnostic criteria for mild to moderate depression were randomly assigned to either a medication(SSRIs)group(36 completed)or a VBT combined group(38 completed)for a 6-week intervention.Baseline and post-intervention assessments includ-ed the Hamilton Depression Scale(HAMD),Hamilton Anxious Scale(HAMA),Ruminative Response Scale-Chi-nese Version(RRS-CV),Iowa Gambling Test(IGT),number of eye fixation(NEF),responsive search score(RSS)in exploratory eye trajectory movement were used to evaluate patients'anxiety and depression symptoms,ru-minative thinking,decision-making function,and cognitive function.Results:The VBT combined group showed sig-nificantly better therapeutic effects than the medication group(P＜0.05).Compared to baseline and the medication group,the VBT combined group had significantly lower post-intervention scores in HAMD,HAMA,symptom rumi-nation,introspective reflection,compulsive meditation,and RRS-CV total scores after intervention(Ps＜0.05),and significantly higher scores in IGT net profit scores,NEF,and RSS scores(Ps＜0.05).Compared with the medica-tion group,the VBT combined group demonstrated a greater reduction in HAMD,HAMA,symptom rumination,in-trospective reflection,compulsive meditation,and RRS-CV total scores before and after intervention(Ps＜0.05),and a larger increase in IGT net profit scores,NEF,and RSS scores(Ps＜0.05).Conclusion:VBT combined with SSRIs effectively improves the symptoms of depression,anxiety,decision-making ability,rumination thinking,and cognitive function in patients with mild to moderate depression.

Objective:To evaluate the effect of value orientation brief therapy(VBT)combined with selective serotonin reuptake inhibitors(SSRIs)on clinical symptoms,rumination,decision-making ability,and cognitive func-tion in patients with mild to moderate depression.Methods:Eighty patients meeting the DSM-5 diagnostic criteria for mild to moderate depression were randomly assigned to either a medication(SSRIs)group(36 completed)or a VBT combined group(38 completed)for a 6-week intervention.Baseline and post-intervention assessments includ-ed the Hamilton Depression Scale(HAMD),Hamilton Anxious Scale(HAMA),Ruminative Response Scale-Chi-nese Version(RRS-CV),Iowa Gambling Test(IGT),number of eye fixation(NEF),responsive search score(RSS)in exploratory eye trajectory movement were used to evaluate patients'anxiety and depression symptoms,ru-minative thinking,decision-making function,and cognitive function.Results:The VBT combined group showed sig-nificantly better therapeutic effects than the medication group(P＜0.05).Compared to baseline and the medication group,the VBT combined group had significantly lower post-intervention scores in HAMD,HAMA,symptom rumi-nation,introspective reflection,compulsive meditation,and RRS-CV total scores after intervention(Ps＜0.05),and significantly higher scores in IGT net profit scores,NEF,and RSS scores(Ps＜0.05).Compared with the medica-tion group,the VBT combined group demonstrated a greater reduction in HAMD,HAMA,symptom rumination,in-trospective reflection,compulsive meditation,and RRS-CV total scores before and after intervention(Ps＜0.05),and a larger increase in IGT net profit scores,NEF,and RSS scores(Ps＜0.05).Conclusion:VBT combined with SSRIs effectively improves the symptoms of depression,anxiety,decision-making ability,rumination thinking,and cognitive function in patients with mild to moderate depression.

OBJECTIVE To explore the effects of different concentrations of aconitine on the ventricular electrophysiology of the rat heart when applied to the heart. METHODS By optical mapping technology, the effects of different concentrations of aconitine on ventricular action potential and calcium signal in rats before and 15 min after administration were observed by in vitro administration of aconitine 0.3, 1, 3 ng·mL−1. RESULTS Compared with the blank group, aconitine could be concentration-dependent to delay the conduction of action potentials under both spontaneous and 6 Hz stimulation rhythms, and there was a significant difference at a concentration of 3 ng·mL−1(P<0.05 or P<0.01). Compared with blank group, when the concentration of aconitine was 1 and 3 ng·mL−1, the action potential duration(APD) of the ventricle was significantly prolonged(P<0.01). Aconitine could also increase the dispersion of action potential conduction(P<0.05) and reduce the ratio of effective refractory period(ERP) to APD90(P<0.01). In addition, aconitine could also be concentration-dependent delay of calcium signal conduction, reduce the speed of calcium conduction(P<0.05 or P<0.01), increase the dispersion of calcium conduction and calcium transient duration(P<0.05 or P<0.01), and reduce the amplitude of calcium signal(P<0.01). CONCLUSION Using the optical labeling technique, it can be visualized that aconitine induces arrhythmia by concentration-dependent delay of ventricular action potential and calcium signaling in rats.To explore the effects of different concentrations of aconitine on the ventricular electrophysiology of the rat heart when applied to the heart. METHODS By optical mapping technology, the effects of different concentrations of aconitine on ventricular action potential and calcium signal in rats before and 15 min after administration were observed by in vitro administration of aconitine 0.3, 1, 3 ng·mL−1. RESULTS Compared with the blank group, aconitine could be concentration-dependent to delay the conduction of action potentials under both spontaneous and 6 Hz stimulation rhythms, and there was a significant difference at a concentration of 3 ng·mL−1(P<0.05 or P<0.01). Compared with blank group, when the concentration of aconitine was 1 and 3 ng·mL−1, the action potential duration(APD) of the ventricle was significantly prolonged(P<0.01). Aconitine could also increase the dispersion of action potential conduction(P<0.05) and reduce the ratio of effective refractory period(ERP) to APD90(P<0.01). In addition, aconitine could also be concentration-dependent delay of calcium signal conduction, reduce the speed of calcium conduction(P<0.05 or P<0.01), increase the dispersion of calcium conduction and calcium transient duration(P<0.05 or P<0.01), and reduce the amplitude of calcium signal(P<0.01). CONCLUSION Using the optical labeling technique, it can be visualized that aconitine induces arrhythmia by concentration-dependent delay of ventricular action potential and calcium signaling in rats.

Humans ; Aripiprazole/therapeutic use* ; Schizophrenia/drug therapy* ; Antipsychotic Agents/therapeutic use* ; Risperidone ; China ; Treatment Outcome

Objective To explore the effect of temperature on the risk of hand-foot-and-mouth disease (HFMD) and population susceptibility. Methods The data of HFMD cases in Chengdu from January 1, 2016 to October 31, 2022 were collected, and local meteorological data during the same period were also collected. Distributional lag nonlinear models were developed. The relative risk (RR) of morbidity at different temperatures and different lags was calculated. Differences in the relative risk levels of different populations were analyzed and compared. Results A total of 263 776 cases of HFDM were reported in Chengdu during the study period. The distribution of HFMD was periodic. For the overall population, the short-term average temperature and RR showed a ^“U^”-shaped relationship. When the lag time was 0-7 days, the cumulative RR was 1.59 (95%CI: 1.18-2.14) at the average temperature of -0.5℃ and 2.16 (95%CI: 1.60-2.91) at the average temperature of 34.5℃. The RR values under high and low temperatures decreased with increasing lag period. When the lag time was extended, the average temperature and RR showed an inverted ^“U^”-shaped relationship, with higher RR at moderate temperatures and increasing as the lag period increased. The results of the subgroups showed that the RR of onset among scattered children was higher at high and low temperatures. Conclusion The risk effect of temperature on the onset of HFMD in different populations is variable and changes with the lag period, and the prevention and control measures should be adjusted in a timely and targeted manner.

OBJECTIVE: Autologous blood acupoint injection has practiced for treatment of various diseases, but its therapeutic mechanism remains unknown. This study aimed to explore the histological changes in the acupoint area after blood injection. METHODS: Blood samples (0.1 mL) collected from donator mice was injected in the recipient mice at the acupoint of left Zusanli (ST- 36). At 0, 6, 12, 24, 48, 72 and 96 h after the injection (3 mice at each time point), peripheral blood and muscular tissue were collected from the injection site for blood cell classification and histological study with HE staining. RESULTS: White blood cells and lymphocytes tended to increase but platelets tended to decrease at the acupoint after blood injection, but these changes were not statistically significant. Within 24 h after blood injection, acute inflammation occurred at the acupoint, and the injected blood components were infiltrated by neutrophils; a small number of monocytes were observed at the injection site, where red blood cells gradually disappeared. From 24 to 96 h, the injected area showed chronic inflammation with infiltration by mononuclear cells, macrophages, and lymphocytes, and the number of fibroblasts increased and neutrophils decreased gradually over time; the local muscle fibers were destroyed, and proliferation of fibrous tissue could be seen. CONCLUSIONS Blood injection at the acupoints can mimic the process of hematoma absorption in the muscular tissue, and local inflammation is initiated to engulf and clear the blood components, which may be the basis for the therapeutic effects induced by acupoint stimulation.

Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76％) men and 11 981 (50.24％) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P＜0.01) and marital status (x2=137.143,P＜0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P＜0.01),gender (Wald x2=13.131,P＜0.01),education level (Wald x2=48.338,P＜0.01),marital status (Wald x2=54.495,P＜0.01) and family history (Wald x2=107.340,P＜0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.

Objective:To understand the current status of drug compliance in patients with serious mental disorder in Henan，and to study its influencing factors.Methods:Using stratified random sampling method. The baseline data of patients were collected by self-designed questionnaires. Logistic regression analysis was conducted to determine associated factors. Independent sample t-test and chi-square test were performed to compare the baseline data of the two groups. Results:A total of 1 872 valid questionnaires were collected, and the rate of medication compliance in patients with serious mental disorder was 51.34%(961). Through multivariate logistic regression analysis, we found that 10 variables, such as relation ship, household income level, and year treatment cost were significantly associated with drug compliance. Conjugal（ Wald χ2=10.491, P=0.001）, and sibling relationship ( Wald χ2=10.472, P=0.001) were the risk factors for drug compliance, and it has an increased tendency. Regarding household income level, compared with the level of ‘good’, the level of ‘very good’, ‘better than good’ （ Wald χ2=4.373, P=0.037）, and ‘moderate’ ( Wald χ2=4.189, P=0.041) were the protective factors for drug compliance, and it has a reducing tendency. In addition, patients′ age (45-59 years)( Wald χ2=7.060, P=0.008), living status (living together with caregivers)（ Wald χ2=32.029， P<0.01）, and residency (urban residents)（ Wald χ2=21.908, P<0.01） were the protective factors for drug compliance. Conclusions:The current status of drug compliance in patients with serious mental disorder in Henan was rigorous, and its influence factors are complicated. The interaction between factors should be comprehensively considered before applying interventions.

Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76％) men and 11 981 (50.24％) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P＜0.01) and marital status (x2=137.143,P＜0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P＜0.01),gender (Wald x2=13.131,P＜0.01),education level (Wald x2=48.338,P＜0.01),marital status (Wald x2=54.495,P＜0.01) and family history (Wald x2=107.340,P＜0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.

Objective:To understand the current status of drug compliance in patients with serious mental disorder in Henan，and to study its influencing factors.Methods:Using stratified random sampling method. The baseline data of patients were collected by self-designed questionnaires. Logistic regression analysis was conducted to determine associated factors. Independent sample t-test and chi-square test were performed to compare the baseline data of the two groups. Results:A total of 1 872 valid questionnaires were collected, and the rate of medication compliance in patients with serious mental disorder was 51.34%(961). Through multivariate logistic regression analysis, we found that 10 variables, such as relation ship, household income level, and year treatment cost were significantly associated with drug compliance. Conjugal（ Wald χ2=10.491, P=0.001）, and sibling relationship ( Wald χ2=10.472, P=0.001) were the risk factors for drug compliance, and it has an increased tendency. Regarding household income level, compared with the level of ‘good’, the level of ‘very good’, ‘better than good’ （ Wald χ2=4.373, P=0.037）, and ‘moderate’ ( Wald χ2=4.189, P=0.041) were the protective factors for drug compliance, and it has a reducing tendency. In addition, patients′ age (45-59 years)( Wald χ2=7.060, P=0.008), living status (living together with caregivers)（ Wald χ2=32.029， P<0.01）, and residency (urban residents)（ Wald χ2=21.908, P<0.01） were the protective factors for drug compliance. Conclusions:The current status of drug compliance in patients with serious mental disorder in Henan was rigorous, and its influence factors are complicated. The interaction between factors should be comprehensively considered before applying interventions.