To address the challenges of fragmented data, inconsistent standards, and delayed feedback in the full-cycle competency development process at teaching hospitals, this paper proposes the LEADS data governance system for Precision Medical Education (LEADS-PME), drawing on the practical experience of building the integrated medical education management platform at Zhongshan Hospital, Fudan University. The LEADS-PME framework comprises five interconnected core components: Longitudinal foundation, Evidence-chain generation, Analytics and profiling, Decision-support and prediction, and Simulation and digital-twin governance. Currently, Zhongshan Hospital has established a full-cycle educational data infrastructure and achieved multi-system data integration and competency-based profiling and evaluation, while the prediction and simulation modules are still in the prototype exploration phase. A mixed-methods evaluation will be subsequently conducted from the perspectives of data quality, management effectiveness, and predictive intervention. As a locally adapted framework, LEADS-PME can transform operational data derived from clinical practice, teaching, assessment, and management processes into traceable, interpretable, and reusable evidence of competency development. It is expected to facilitate the transformation of medical education management from a outcome-oriented approach to process monitoring, evidence-driven decision-making, and precision governance, thereby providing both a theoretical framework and practical reference for precision medical education in Chinese teaching hospitals.

ObjectiveTo evaluate the roles of imbalance between peripheral blood T helper 17 (Th17) cells and CD4+CD25+ regulatory T(Treg) cells in the pathogenesis of atopic dermatitis (AD).Methods Peripheral blood samples were obtained from 52 patients with AD aged 2-14 years and 30 age- and sex-matched healthy controls.Flow cytometry was performed to detect the percentage of Th17 cells and Treg cells in peripheral blood.Meanwhile,enzyme linked immunosorbent assay(ELISA) was carried out to detect the serumlevel of interleukin (IL)-6 and transforming growth factor (TGF)-β1.Results The children with AD showed a higher percentage of Th17 cells but a lower percentage of Treg cells in CD3+ T cells compared with the controls (( 1.20 ± 0.41 )％ vs.(0.54 ± 0.28)％,t =2.58,P ＜ 0.05; (2.29 ± 0.67)％ vs.(5.95 ± 0.45)％,t =15.23,P ＜ 0.01 ).Moreover,the serum level of IL-6 was significantly higher,while that of TGF-β1 was lower in patients with AD than in the controls ((5.12 ± 0.45) ng/L vs.(3.89 ± 0.38) ng/L,t =2.59,P＜ 0.05; (57.65 ± 10.78) ng/L vs. (81.18 ± 7.78) ng/L,t =5.41,P ＜ 0.01 ).ConclusionsChildren with AD experience a change in the percentage of Thl7 cells and Treg cells in peripheral blood as well as in the serum level of IL-6 and TGF-β1,and the imbalance between Th17 cells and Treg cells in peripheral blood may contribute to the development of AD.