Interleukin-33(IL-33)is a member of the interleukin-1 superfamily and a"warning fac-tor"for inflammation in the body.When cells die or tissues are damaged,IL-33 is released in large quantities and binds to its receptor ST2 to form a complex,exerting various biological effects.IL-33/ST2 signaling pathway is activated in many kidney diseases,such as acute renal injury,obstructive ne-phropathy,diabetes nephropathy,IgA nephropathy,lupus nephritis,and kidney transplantation.It plays an important role in inflammation and renal fibro-sis by regulating the intrinsic and adaptive immune responses of the kidney.This article reviews the re-search progress of IL-33/ST2 signaling in common kidney diseases,hoping to provide new targets and ideas for the treatment of kidney diseases.

Interleukin-33(IL-33)is a member of the interleukin-1 superfamily and a"warning fac-tor"for inflammation in the body.When cells die or tissues are damaged,IL-33 is released in large quantities and binds to its receptor ST2 to form a complex,exerting various biological effects.IL-33/ST2 signaling pathway is activated in many kidney diseases,such as acute renal injury,obstructive ne-phropathy,diabetes nephropathy,IgA nephropathy,lupus nephritis,and kidney transplantation.It plays an important role in inflammation and renal fibro-sis by regulating the intrinsic and adaptive immune responses of the kidney.This article reviews the re-search progress of IL-33/ST2 signaling in common kidney diseases,hoping to provide new targets and ideas for the treatment of kidney diseases.