OBJECTIVE: To evaluate precise assessment methods for predicting the optimal acetabular cup size in total hip arthroplasty (THA). METHODS: A clinical data of 73 patients (80 hips) who underwent primary THA between December 2022 and July 2024 and met the inclusion criteria was analyzed. There were 39 males and 34 females with an average age of 66.3 years (range, 56-78 years). Among them, 66 cases were unilateral THA and 7 were bilateral THAs. There were 29 patients (34 hips) of osteoarthritis, 35 patients (35 hips) of femoral neck fractures, and 9 patients (11 hips) of osteonecrosis of the femoral head. Based on anteroposterior pelvic X-ray films, three methods were employed to predict acetabular cup size, including preoperative template planning, radiographic femoral head diameter (FHD) measurement, and intraoperative FHD measurement. The predicted acetabular cup sizes from these methods were compared with the actual implanted sizes. RESULTS: The predicted acetabular cup sizes using the preoperative template planning, radiographic FHD measurement, and intraoperative FHD measurement were (51.25±2.81), (49.72±3.11), and (49.90±2.74) mm, respectively, compared to the actual implanted cup size of (50.57±2.74) mm, with no significant difference ( P>0.05). Regarding agreement with the actual implanted cup size, the preoperative template planning achieved exact matches in 35 hips (43.75%), one-size deviation in 41 hips (51.25%), and two-size deviations in 4 hips (5%); the radiographic FHD measurement achieved exact matches in 12 hips (15%), one-size deviation in 57 hips (71.25%), and two-size deviations in 11 hips (13.75%); and the intraoperative FHD measurement achieved exact matches in 26 hips (32.5%), one-size deviation in 52 hips (65%), and two-size deviations in 2 hips (2.5%). There were significant differences in agreement distributions between the three methods and the actual implanted cup sizes ( H=18.579, P<0.001). CONCLUSION The intraoperative FHD measurement, as a simple, cost-effective, and accurate method, effectively guides acetabular cup selection, reduces the risk of prosthesis wear, enhances postoperative joint stability.
Humans ; Arthroplasty, Replacement, Hip/instrumentation* ; Male ; Female ; Middle Aged ; Acetabulum/diagnostic imaging* ; Aged ; Hip Prosthesis ; Prosthesis Design ; Femur Head/surgery* ; Osteoarthritis, Hip/surgery* ; Radiography ; Femoral Neck Fractures/surgery* ; Femur Head Necrosis/surgery*

Aim To investigate the role of miR-130b-3p in regulating the USP47/NLRP3 inflammasome in airway remodeling associated with asthma and to explore its potential therapeutic value in asthma treat-ment.Methods An OVA-induced asthma mouse mod-el was established,and intervention with miR-130b-3p agomir was performed.Histological staining,quantita-tive real-time PCR,Western blot,immunofluorescence and flow cytometry were used to analyze the effects of miR-130b-3p on the expression of USP47,NLRP3,and related inflammatory factors,as well as the inflamma-some activity.Results miR-130b-3p was significantly downregulated in asthmatic mice,and its intervention significantly inhibited airway epithelial damage,inflam-matory cell infiltration,and collagen deposition.Addi-tionally,miR-130b-3p targeted USP47 and indirectly suppressed NLRP3 expression,leading to reduced in-flammasome activity and alleviated asthma-related in-flammatory responses.Conclusion miR-130b-3p re-duces asthma-related inflammatory responses by down-regulating USP47 expression and indirectly inhibiting NLRP3 inflammasome activity.

Objective To introduce how to import and analyze data using the Research Electronic Data Capture(REDCap)system,taking a multi-center randomized controlled clinical research of total knee arthroplasty as an example.Methods Various tools within the REDCap system,including data import tools,data export functions,reports and statistics,project dashboards,and coding manuals,were used to systematically process and analyze the multi-center randomized controlled clinical trial data for total knee arthroplasty.Initially,electronically collected clinical data were adjusted and standardized,then uploaded in bulk to the system using the REDCap data import tool.Subsequently,the data were organized through REDCap's data export feature,and basic descriptive statistical analysis was performed using its reporting and statistical functions to ensure data quality and completeness.Results An electronic data collection and management platform for clinical research on knee osteoarthritis wase successfully created by the REDCap system.The platform enabled real-time data collection from multiple centers,and ensured data accuracy and consistency through built-in data management and quality control mechanisms.With the statistical analysis features of REDCap,the research team could monitor the progress of data in real time,conduct effective quality assessments,and perform dynamic analysis for further in-depth statistical evaluations.Conclusion The REDCap system can be used not only to build a new clinical research project,but also to import and analyze data that has been previously digitized of ongoing clinical researches into the system,which improved the scientificity of data management and research efficiency.

Aim To investigate the role of miR-130b-3p in regulating the USP47/NLRP3 inflammasome in airway remodeling associated with asthma and to explore its potential therapeutic value in asthma treat-ment.Methods An OVA-induced asthma mouse mod-el was established,and intervention with miR-130b-3p agomir was performed.Histological staining,quantita-tive real-time PCR,Western blot,immunofluorescence and flow cytometry were used to analyze the effects of miR-130b-3p on the expression of USP47,NLRP3,and related inflammatory factors,as well as the inflamma-some activity.Results miR-130b-3p was significantly downregulated in asthmatic mice,and its intervention significantly inhibited airway epithelial damage,inflam-matory cell infiltration,and collagen deposition.Addi-tionally,miR-130b-3p targeted USP47 and indirectly suppressed NLRP3 expression,leading to reduced in-flammasome activity and alleviated asthma-related in-flammatory responses.Conclusion miR-130b-3p re-duces asthma-related inflammatory responses by down-regulating USP47 expression and indirectly inhibiting NLRP3 inflammasome activity.

Objective To introduce how to import and analyze data using the Research Electronic Data Capture(REDCap)system,taking a multi-center randomized controlled clinical research of total knee arthroplasty as an example.Methods Various tools within the REDCap system,including data import tools,data export functions,reports and statistics,project dashboards,and coding manuals,were used to systematically process and analyze the multi-center randomized controlled clinical trial data for total knee arthroplasty.Initially,electronically collected clinical data were adjusted and standardized,then uploaded in bulk to the system using the REDCap data import tool.Subsequently,the data were organized through REDCap's data export feature,and basic descriptive statistical analysis was performed using its reporting and statistical functions to ensure data quality and completeness.Results An electronic data collection and management platform for clinical research on knee osteoarthritis wase successfully created by the REDCap system.The platform enabled real-time data collection from multiple centers,and ensured data accuracy and consistency through built-in data management and quality control mechanisms.With the statistical analysis features of REDCap,the research team could monitor the progress of data in real time,conduct effective quality assessments,and perform dynamic analysis for further in-depth statistical evaluations.Conclusion The REDCap system can be used not only to build a new clinical research project,but also to import and analyze data that has been previously digitized of ongoing clinical researches into the system,which improved the scientificity of data management and research efficiency.

Objectives: This study aimed to present the Asia-Pacific consensus on long-term and sequential therapy for osteoporosis, offering evidence-based recommendations for the effective management of this chronic condition.The primary focus is on achieving optimal fracture prevention through a comprehensive, individualized approach. Methods: A panel of experts convened to develop consensus statements by synthesizing the current literature and leveraging clinical expertise. The review encompassed long-term anti-osteoporosis medication goals, first-line treatments for individuals at very high fracture risk, and the strategic integration of anabolic and anti resorptive agents in sequential therapy approaches. Results: The panelists reached a consensus on 12 statements. Key recommendations included advocating for anabolic agents as the first-line treatment for individuals at very high fracture risk and transitioning to anti resorptive agents following the completion of anabolic therapy. Anabolic therapy remains an option for in dividuals experiencing new fractures or persistent high fracture risk despite antiresorptive treatment. In cases of inadequate response, the consensus recommended considering a switch to more potent medications. The consensus also addressed the management of medication-related complications, proposing alternatives instead of discontinuation of treatment. Conclusions This consensus provides a comprehensive, cost-effective strategy for fracture prevention with an emphasis on shared decision-making and the incorporation of country-specific case management systems, such as fracture liaison services. It serves as a valuable guide for healthcare professionals in the Asia-Pacific region, contributing to the ongoing evolution of osteoporosis management.

Objective:To investigate the correlation between three-dimensional (3D) true acetabular cup coverage and two-dimensional (2D) X-ray acetabular cup coverage in total hip arthroplasty (THA) and identify effective parameters for evaluating acetabular cup coverage.Methods:Sixteen pelvic models were 3D-printed from CT reconstruction data of healthy adult pelvises. Postoperative acetabular models were prepared using standard THA procedures. The postoperative models were centered on the acetabulum and positioned under a C-arm fluoroscope. Fluoroscopy was conducted by rotating the C-arm at different angles (15°, 30°, and 45°) to obtain anteroposterior (AP) and iliac oblique X-ray images of the hip joint. The 2D acetabular coverage at different fluoroscopic angles (AP, 15° iliac oblique, 30° iliac oblique, and 45° iliac oblique) was recorded and compared with the 3D acetabular coverage measured from the pelvic models. Two independent observers assessed related parameters (coverage, abduction angle, anteversion angle) from the 2D X-ray images, and inter-observer reliability was statistically analyzed. Differences between 2D and 3D acetabular coverage were compared, and multiple linear regression analysis was used to assess correlations between acetabular anteversion angle, abduction angle, and both 2D and 3D acetabular coverage.Results:The acetabular coverage for the 2D X-ray groups (AP, 15° iliac oblique, 30° iliac oblique, and 45° iliac oblique) was 87.37%±2.59%, 87.01%±2.53%, 85.39%±2.57%, and 83.20%±2.51%, respectively, with statistically significant differences ( F=6.700, P=0.001). The 45° iliac oblique group had significantly lower coverage than both the 30° iliac oblique group and the AP group, while the 30° iliac oblique group showed significantly lower coverage than the 15° iliac oblique group (all differences, P<0.05). The mean abduction and anteversion angles were 45.33°±2.22° and 14.61°±2.53°, respectively. The 3D acetabular coverage was 85.66%±2.51%. The 45° iliac oblique group had significantly lower coverage than the 3D coverage group ( P<0.05), whereas no significant difference was observed between the AP group and the 3D coverage group ( t=1.893, P=0.062). Multiple linear regression analysis revealed significant negative correlations between the acetabular abduction angle, anteversion angle, and both 2D and 3D acetabular coverage, with the following regression equations: 2D coverage=124.627-0.700× (abduction angle) -0.379× (anteversion angle) ( R2=0.814, P=0.001); 3D coverage=120.291-0.603× (abduction angle) -0.499× (anteversion angle) ( R2=0.917, P<0.001). Conclusion:Acetabular cup coverage rates vary with different X-ray projection angles, with the anteroposterior X-ray view potentially overestimating coverage. Changes in the abduction angle appear to significantly impact the differences between 2D and 3D coverage, thereby increasing errors in assessing true acetabular cup coverage. These discrepancies between 2D and 3D coverage should be carefully considered when evaluating minimal acetabular cup coverage.

Objective:To investigate the correlation between three-dimensional (3D) true acetabular cup coverage and two-dimensional (2D) X-ray acetabular cup coverage in total hip arthroplasty (THA) and identify effective parameters for evaluating acetabular cup coverage.Methods:Sixteen pelvic models were 3D-printed from CT reconstruction data of healthy adult pelvises. Postoperative acetabular models were prepared using standard THA procedures. The postoperative models were centered on the acetabulum and positioned under a C-arm fluoroscope. Fluoroscopy was conducted by rotating the C-arm at different angles (15°, 30°, and 45°) to obtain anteroposterior (AP) and iliac oblique X-ray images of the hip joint. The 2D acetabular coverage at different fluoroscopic angles (AP, 15° iliac oblique, 30° iliac oblique, and 45° iliac oblique) was recorded and compared with the 3D acetabular coverage measured from the pelvic models. Two independent observers assessed related parameters (coverage, abduction angle, anteversion angle) from the 2D X-ray images, and inter-observer reliability was statistically analyzed. Differences between 2D and 3D acetabular coverage were compared, and multiple linear regression analysis was used to assess correlations between acetabular anteversion angle, abduction angle, and both 2D and 3D acetabular coverage.Results:The acetabular coverage for the 2D X-ray groups (AP, 15° iliac oblique, 30° iliac oblique, and 45° iliac oblique) was 87.37%±2.59%, 87.01%±2.53%, 85.39%±2.57%, and 83.20%±2.51%, respectively, with statistically significant differences ( F=6.700, P=0.001). The 45° iliac oblique group had significantly lower coverage than both the 30° iliac oblique group and the AP group, while the 30° iliac oblique group showed significantly lower coverage than the 15° iliac oblique group (all differences, P<0.05). The mean abduction and anteversion angles were 45.33°±2.22° and 14.61°±2.53°, respectively. The 3D acetabular coverage was 85.66%±2.51%. The 45° iliac oblique group had significantly lower coverage than the 3D coverage group ( P<0.05), whereas no significant difference was observed between the AP group and the 3D coverage group ( t=1.893, P=0.062). Multiple linear regression analysis revealed significant negative correlations between the acetabular abduction angle, anteversion angle, and both 2D and 3D acetabular coverage, with the following regression equations: 2D coverage=124.627-0.700× (abduction angle) -0.379× (anteversion angle) ( R2=0.814, P=0.001); 3D coverage=120.291-0.603× (abduction angle) -0.499× (anteversion angle) ( R2=0.917, P<0.001). Conclusion:Acetabular cup coverage rates vary with different X-ray projection angles, with the anteroposterior X-ray view potentially overestimating coverage. Changes in the abduction angle appear to significantly impact the differences between 2D and 3D coverage, thereby increasing errors in assessing true acetabular cup coverage. These discrepancies between 2D and 3D coverage should be carefully considered when evaluating minimal acetabular cup coverage.

OBJECTIVE: To compare the short-term clinical efficacy of SuperCap approach and direct anterior approach in total hip arthroplasty. METHODS: Clinical data of 70 patients who underwent minimally invasive SuperCap approach and DAA THA in January 2016 to June 2017 were retrospective analyzed. These patients were divided into two groups:SuperCap approach group(SuperCap group) and direct anterior approach group(DAA group). There were 15 males and 15 females in SuperCap group, aged from 45 to 71 years old, and the follow-up time ranged from 24 to 30 months. There were 24 males and 16 females in Group B, aged from 51 to 76 years and the follow-up time ranged from 24 to 36 months. Hemoglobin level of the 3rd day after operation, transfusion rate, acetabular abduction angle, anteversion angle and creatine kinase level of the 3rd day after operation, Harris score of 3 months and the last time, VAS score of 1 week and the last time were recorded and compared. Complications were recorded at the final follow-up. RESULTS: All patients were followed up, the follow-up time of SuperCap group ranged from 24 to 30 months, that of DAA group ranged from 24 to 36 months. No significant differences were found in hemoglobin level on the 3rd day after operation, transfusion rate, Harris score or VAS score between two group (P>0.05). There was no significant difference in Harris score between 3 months after operation and the final follow-up in both groups (P>0.05). There were no significant difference in VAS scores of 6 weeks after operation and on the final follow-up neither(P>0.05). The level of creatine kinase in SuperCap group was significant lower than that in DAA group(P<0.05). Until the final follow-up, there was no significant difference in the incidence of complications between the two groups(P>0.05). CONCLUSION The clinical effect of minimally invasive SuperCap approach after total hip arthroplasty is comparable to that of DAA approach with less soft tissue injury. Patients can recover rapidly after operation and it is a safe and effective surgical approach for surgeons with short learning curve.
Male ; Female ; Humans ; Middle Aged ; Aged ; Arthroplasty, Replacement, Hip ; Retrospective Studies ; Antiviral Agents ; Treatment Outcome ; Creatine Kinase ; Hemoglobins

The formulation and revision of the detection methods of indoor air quality standards is an important, rigorous and delicate endeavor. This paper introduced the formulation and revision of the detection methods of the standards for indoor air quality (GB/T 18883-2022), focusing on the revision process, revision principles, main adjustments and technical points of some key indicators to facilitate users to better understand and apply the detection methods in standards for indoor air quality (GB/T 18883-2022).
Humans ; Air Pollution, Indoor ; China ; Reference Standards ; Air Pollutants/analysis*