1.Research progress on the application of intelligent medical treatment in abdominal war trauma
Si-Zhe WANG ; Xu SUN ; Ding-Chang LI ; Xian-Qiang LIU ; Wen-Xing GAO ; Wen ZHAO ; Hao LIU ; Guang-Long DONG
Medical Journal of Chinese People's Liberation Army 2025;50(1):22-27
Abdominal war trauma is a common and high-risk type of injury in the modern battlefield,with rapid changes in condition and a high mortality rate.There is an urgent need for emerging medical technologies to improve the efficiency and success rate of first aid for military casualties.With the development of artificial intelligence(AI),5G,and other emerging technologies,the concept of intelligent medical treatment is gradually forming and can assist in the diagnosis and treatment of abdominal trauma.This paper reviews the characteristics of abdominal war trauma in modern wars,discusses the application of intelligent medical treatment for abdominal war trauma and its drawbacks to be solved,aiming to provide reference for research related to abdominal war trauma.
2.Advances in the application of machine learning-related combined models in infectious disease prediction
Weihua HU ; Huimin SUN ; Yikun CHANG ; Jinwei CHEN ; Zhicheng DU ; Yongyue WEI ; Yuantao HAO
Chinese Journal of Epidemiology 2025;46(6):1085-1094
When the epidemiology of infectious diseases is more complex, it is often difficult for disease prediction studies based on a single model to capture the multidimensional nature of disease transmission. In recent years, combining different models to improve infectious disease prediction has gradually become a research trend and hotspot. Existing studies have shown that combined models usually have higher prediction performance and better generalization ability. The current combined models mainly combine machine learning and other models, including time-series models, dynamic models, etcetera. In addition, integrated learning that combines diverse machine learning techniques also holds significant importance across various research domains. This paper reviews the progress of applying combined models around machine learning in infectious disease prediction to promote the innovation and practice of combined models for infectious diseases and help to build smarter and more efficient infectious disease early warning and prediction methods and systems.
3.Progress in application of compartment model-related combined models in infectious disease prediction
Weihua HU ; Huimin SUN ; Yikun CHANG ; Jinwei CHEN ; Zhicheng DU ; Yongyue WEI ; Yuantao HAO
Chinese Journal of Epidemiology 2025;46(7):1289-1296
Methods such as compartmental models, agent-based models, time series models, and machine learning can be used for the prediction of infectious disease incidence. When disease epidemics are complex, it is often difficult to use a single model to comprehensively and accurately capture the multi dimensional nature of the disease. Exploring the combined application of different models has gradually become a research trend and hotspot in recent years, and the prediction performance of combined models is often better than that of single ones. Current research related to combined models mainly focus on machine learning or compartmental models. In this review, we focus on the combination of compartmental models and other models, and summarize their combination principles, application progress, and advantages or disadvantages for the purpose of promoting the innovation and application of combined models for infectious disease incidence prediction, and establishing a more intelligent and efficient early warning and prediction method or systems for the prevention and control of infectious disease.
4.Comparative study of blue Laser imaging combined with magnifying endoscope and white light endoscope in the detection of esophagogastric junction lesions
Chang LIU ; Yumeng SUN ; Xin HAO ; Haiyang HUA ; Changzhou LI ; Jianhui LI
China Journal of Endoscopy 2025;31(1):32-39
Objective To explore the applicative value of blue Laser imaging combined with magnifying endoscope(BLI+ME)system for the lesion of esophagogastric junction(EGJ).Methods Retrospective study endoscopic and pathological reported during February 2022 to February 2024.6 803 patients who met the inclusion and exclusion criteria were enrolled.They were divided into BLI+ME group(2 931 cases)and white light imaging group(WLI group,3 872 cases)according to the different gastroscopy types used in the examination.Finally,the EGJ biopsy rate,positive biopsy rate,detection rate of various lesions and early diagnosis rate between the two groups were compared.Results The biopsy rate of the BLI+ME group was 27.60%,the positive biopsy rate was 68.73%,and the detection rate of all the lesions was 20.74%,the detection rate of non-cancerous lesions was 20.30%,the detection rate of early cancer was 0.10%,the detection rate of non-cancerous lesions above the dentate line was 5.53%,the detection rate of non-cancerous lesions below the dentate line was 14.77%,the detection rate of cancerous lesions below the dentate line was 0.27%,significantly higher than those of the WLI group,which the biopsy rate was 17.74%,the positive biopsy rate was 60.26%,and the detection rate of all the lesions was 11.90%,the detection rate of non-cancerous lesions was 11.67%,the detection rate of early cancer was 0.00%,the detection rate of non-cancerous lesions above the dentate line was 3.49%,the detection rate of non-cancerous lesions below the dentate line was 8.19%,the detection rate of cancerous lesions below the dentate line was 0.05%,the differences were statistically significant(P<0.05).Conclusion The BLI+ME system can enhance the biopsy rate,positive biopsy rate,the detection rate of all the lesions,early cancer detection rate,non-cancerous lesions detection rate above and below the dentate line,and cancerous lesions detection rate below the dentate line at the EGJ.It is helpful to improve the early diagnosis rate and early treatment rate of EGJ.It is worthy of clinical application.
5.Cost-effectiveness of Fractional Flow Reserve Versus Intravascular Ultrasound to Guide Percutaneous Coronary Intervention: Results From the FLAVOUR Study
Doyeon HWANG ; Hea-Lim KIM ; Jane KO ; HyunJin CHOI ; Hanna JEONG ; Sun-ae JANG ; Xinyang HU ; Jeehoon KANG ; Jinlong ZHANG ; Jun JIANG ; Joo-Yong HAHN ; Chang-Wook NAM ; Joon-Hyung DOH ; Bong-Ki LEE ; Weon KIM ; Jinyu HUANG ; Fan JIANG ; Hao ZHOU ; Peng CHEN ; Lijiang TANG ; Wenbing JIANG ; Xiaomin CHEN ; Wenming HE ; Sung Gyun AHN ; Ung KIM ; You-Jeong KI ; Eun-Seok SHIN ; Hyo-Soo KIM ; Seung-Jea TAHK ; JianAn WANG ; Tae-Jin LEE ; Bon-Kwon KOO ;
Korean Circulation Journal 2025;55(1):34-46
Background and Objectives:
The Fractional Flow Reserve and Intravascular UltrasoundGuided Intervention Strategy for Clinical Outcomes in Patients with Intermediate Stenosis (FLAVOUR) trial demonstrated non-inferiority of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) compared with intravascular ultrasound (IVUS)-guided PCI. We sought to investigate the cost-effectiveness of FFR-guided PCI compared to IVUS-guided PCI in Korea.
Methods:
A 2-part cost-effectiveness model, composed of a short-term decision tree model and a long-term Markov model, was developed for patients who underwent PCI to treat intermediate stenosis (40% to 70% stenosis by visual estimation on coronary angiography).The lifetime healthcare costs and quality-adjusted life-years (QALYs) were estimated from the healthcare system perspective. Transition probabilities were mainly referred from the FLAVOUR trial, and healthcare costs were mainly obtained through analysis of Korean National Health Insurance claims data. Health utilities were mainly obtained from the Seattle Angina Questionnaire responses of FLAVOUR trial participants mapped to EQ-5D.
Results:
From the Korean healthcare system perspective, the base-case analysis showed that FFR-guided PCI was 2,451 U.S. dollar lower in lifetime healthcare costs and 0.178 higher in QALYs compared to IVUS-guided PCI. FFR-guided PCI remained more likely to be cost-effective over a wide range of willingness-to-pay thresholds in the probabilistic sensitivity analysis.
Conclusions
Based on the results from the FLAVOUR trial, FFR-guided PCI is projected to decrease lifetime healthcare costs and increase QALYs compared with IVUS-guided PCI in intermediate coronary lesion, and it is a dominant strategy in Korea.
6.Cross sectional and cross lagged network analyses of Internet addiction among university students
GOU Hao, HUANG Wenying, SUN Qunqun, HU Chang, ZHANG Wen, XIANG Luyao, SONG Chao
Chinese Journal of School Health 2025;46(9):1287-1291
Objective:
To understand the dynamic temporal evolution pathways of Internet addiction among university students and to identify the core driving nodes, so as to provide theoretical evidences for the precise implementation of targeted interventions.
Methods:
Using a convenient cluster sampling method, a total of 1 066 full time freshmen and sophomores were recruited from three universities in Guizhou, Jiangxi, and Guangdong Provinces for a follow up survey (T1:January-March 2024; T2:January-March 2025). The Revised Chen Internet Addiction Scale (CIAS-R) was employed to assess the status of Internet addiction among university students, and cross sectional as well as cross lagged panel network models were constructed to analyze Internet addiction and its multidimensional influencing factors.
Results:
The T1 network comprised 19 nodes and 114 non zero edges, while the T2 network comprised 19 nodes and 126 non zero edges. Cross sectional network analysis revealed the strongest association between "insufficient sleep" and "daytime fatigue"; the core nodes were "first thought upon waking for going online" and "feeling low after disconnection" (characteristics of psychological dependence) at T1, while the core nodes shifted to "impaired health" and "excitement when online" (characteristics of functional impairment and addictive psychodynamic features) at T2. Cross lagged network analysis further indicated that "reduced leisure" directly predicted "sleep compression", and a bidirectional relationship was observed between "needing more time to achieve satisfaction" and "academic decline".
Conclusions
Internet addiction among university students exhibits dynamic evolutionary characteristics. Stage specific targeted interventions focusing on core driving nodes are needed, integrating behavioral regulation and academic support to break the vicious cycle and enhancing the ability to cope with real life demands.
7.Cost-effectiveness of Fractional Flow Reserve Versus Intravascular Ultrasound to Guide Percutaneous Coronary Intervention: Results From the FLAVOUR Study
Doyeon HWANG ; Hea-Lim KIM ; Jane KO ; HyunJin CHOI ; Hanna JEONG ; Sun-ae JANG ; Xinyang HU ; Jeehoon KANG ; Jinlong ZHANG ; Jun JIANG ; Joo-Yong HAHN ; Chang-Wook NAM ; Joon-Hyung DOH ; Bong-Ki LEE ; Weon KIM ; Jinyu HUANG ; Fan JIANG ; Hao ZHOU ; Peng CHEN ; Lijiang TANG ; Wenbing JIANG ; Xiaomin CHEN ; Wenming HE ; Sung Gyun AHN ; Ung KIM ; You-Jeong KI ; Eun-Seok SHIN ; Hyo-Soo KIM ; Seung-Jea TAHK ; JianAn WANG ; Tae-Jin LEE ; Bon-Kwon KOO ;
Korean Circulation Journal 2025;55(1):34-46
Background and Objectives:
The Fractional Flow Reserve and Intravascular UltrasoundGuided Intervention Strategy for Clinical Outcomes in Patients with Intermediate Stenosis (FLAVOUR) trial demonstrated non-inferiority of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) compared with intravascular ultrasound (IVUS)-guided PCI. We sought to investigate the cost-effectiveness of FFR-guided PCI compared to IVUS-guided PCI in Korea.
Methods:
A 2-part cost-effectiveness model, composed of a short-term decision tree model and a long-term Markov model, was developed for patients who underwent PCI to treat intermediate stenosis (40% to 70% stenosis by visual estimation on coronary angiography).The lifetime healthcare costs and quality-adjusted life-years (QALYs) were estimated from the healthcare system perspective. Transition probabilities were mainly referred from the FLAVOUR trial, and healthcare costs were mainly obtained through analysis of Korean National Health Insurance claims data. Health utilities were mainly obtained from the Seattle Angina Questionnaire responses of FLAVOUR trial participants mapped to EQ-5D.
Results:
From the Korean healthcare system perspective, the base-case analysis showed that FFR-guided PCI was 2,451 U.S. dollar lower in lifetime healthcare costs and 0.178 higher in QALYs compared to IVUS-guided PCI. FFR-guided PCI remained more likely to be cost-effective over a wide range of willingness-to-pay thresholds in the probabilistic sensitivity analysis.
Conclusions
Based on the results from the FLAVOUR trial, FFR-guided PCI is projected to decrease lifetime healthcare costs and increase QALYs compared with IVUS-guided PCI in intermediate coronary lesion, and it is a dominant strategy in Korea.
8.Cost-effectiveness of Fractional Flow Reserve Versus Intravascular Ultrasound to Guide Percutaneous Coronary Intervention: Results From the FLAVOUR Study
Doyeon HWANG ; Hea-Lim KIM ; Jane KO ; HyunJin CHOI ; Hanna JEONG ; Sun-ae JANG ; Xinyang HU ; Jeehoon KANG ; Jinlong ZHANG ; Jun JIANG ; Joo-Yong HAHN ; Chang-Wook NAM ; Joon-Hyung DOH ; Bong-Ki LEE ; Weon KIM ; Jinyu HUANG ; Fan JIANG ; Hao ZHOU ; Peng CHEN ; Lijiang TANG ; Wenbing JIANG ; Xiaomin CHEN ; Wenming HE ; Sung Gyun AHN ; Ung KIM ; You-Jeong KI ; Eun-Seok SHIN ; Hyo-Soo KIM ; Seung-Jea TAHK ; JianAn WANG ; Tae-Jin LEE ; Bon-Kwon KOO ;
Korean Circulation Journal 2025;55(1):34-46
Background and Objectives:
The Fractional Flow Reserve and Intravascular UltrasoundGuided Intervention Strategy for Clinical Outcomes in Patients with Intermediate Stenosis (FLAVOUR) trial demonstrated non-inferiority of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) compared with intravascular ultrasound (IVUS)-guided PCI. We sought to investigate the cost-effectiveness of FFR-guided PCI compared to IVUS-guided PCI in Korea.
Methods:
A 2-part cost-effectiveness model, composed of a short-term decision tree model and a long-term Markov model, was developed for patients who underwent PCI to treat intermediate stenosis (40% to 70% stenosis by visual estimation on coronary angiography).The lifetime healthcare costs and quality-adjusted life-years (QALYs) were estimated from the healthcare system perspective. Transition probabilities were mainly referred from the FLAVOUR trial, and healthcare costs were mainly obtained through analysis of Korean National Health Insurance claims data. Health utilities were mainly obtained from the Seattle Angina Questionnaire responses of FLAVOUR trial participants mapped to EQ-5D.
Results:
From the Korean healthcare system perspective, the base-case analysis showed that FFR-guided PCI was 2,451 U.S. dollar lower in lifetime healthcare costs and 0.178 higher in QALYs compared to IVUS-guided PCI. FFR-guided PCI remained more likely to be cost-effective over a wide range of willingness-to-pay thresholds in the probabilistic sensitivity analysis.
Conclusions
Based on the results from the FLAVOUR trial, FFR-guided PCI is projected to decrease lifetime healthcare costs and increase QALYs compared with IVUS-guided PCI in intermediate coronary lesion, and it is a dominant strategy in Korea.
9.Advances in the application of machine learning-related combined models in infectious disease prediction
Weihua HU ; Huimin SUN ; Yikun CHANG ; Jinwei CHEN ; Zhicheng DU ; Yongyue WEI ; Yuantao HAO
Chinese Journal of Epidemiology 2025;46(6):1085-1094
When the epidemiology of infectious diseases is more complex, it is often difficult for disease prediction studies based on a single model to capture the multidimensional nature of disease transmission. In recent years, combining different models to improve infectious disease prediction has gradually become a research trend and hotspot. Existing studies have shown that combined models usually have higher prediction performance and better generalization ability. The current combined models mainly combine machine learning and other models, including time-series models, dynamic models, etcetera. In addition, integrated learning that combines diverse machine learning techniques also holds significant importance across various research domains. This paper reviews the progress of applying combined models around machine learning in infectious disease prediction to promote the innovation and practice of combined models for infectious diseases and help to build smarter and more efficient infectious disease early warning and prediction methods and systems.
10.Progress in application of compartment model-related combined models in infectious disease prediction
Weihua HU ; Huimin SUN ; Yikun CHANG ; Jinwei CHEN ; Zhicheng DU ; Yongyue WEI ; Yuantao HAO
Chinese Journal of Epidemiology 2025;46(7):1289-1296
Methods such as compartmental models, agent-based models, time series models, and machine learning can be used for the prediction of infectious disease incidence. When disease epidemics are complex, it is often difficult to use a single model to comprehensively and accurately capture the multi dimensional nature of the disease. Exploring the combined application of different models has gradually become a research trend and hotspot in recent years, and the prediction performance of combined models is often better than that of single ones. Current research related to combined models mainly focus on machine learning or compartmental models. In this review, we focus on the combination of compartmental models and other models, and summarize their combination principles, application progress, and advantages or disadvantages for the purpose of promoting the innovation and application of combined models for infectious disease incidence prediction, and establishing a more intelligent and efficient early warning and prediction method or systems for the prevention and control of infectious disease.


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