Lichen planus (LP) is a relatively common mucocutaneous disease with autoimmune etiology. Considering its malignancy potential, it is important to define the correct diagnosis, treatment, and clinical follow-up for patients with LP so that the disease is not diagnosed late, thus hindering the chances of curing the disease. This study aims to describe a clinical case of oral squamous cell carcinoma, potentially originated from LP. The patient is undergoing clinical and histopathological follow-up. A 64-year-old Caucasian male patient presented with a proliferative verrucous lesion on the tongue and sought treatment at the School of Dentistry, University of Passo Fundo (UPF), Passo Fundo, Brazil. He claimed the lesion had been present since 1988, and had been initially diagnoses as “oral lichen planus.” The physical exam presented three diagnostic hypotheses: plaque-like oral LP, verrucous carcinoma, and squamous cell carcinoma. After incisional biopsy and histopathological analysis, squamous cell carcinoma was diagnosed, probably originating from oral LP. The case study shows that malignancy from oral LP is possible, which justifies periodic clinical and histopathological follow-up, as well as the elimination of risk factors for carcinoma in patients with oral LP.
Biopsy ; Brazil ; Carcinoma, Squamous Cell* ; Carcinoma, Verrucous ; Dentistry ; Diagnosis ; Epithelial Cells* ; Follow-Up Studies ; Humans ; Lichen Planus ; Lichen Planus, Oral* ; Lichens ; Male ; Middle Aged ; Mouth Neoplasms ; Risk Factors ; Tongue

Carcinoma in the external auditory canal (EAC) is a rare malignancy with an annual incidence of one per one million people, accounting for less than 0.2% of all head and neck cancers. The most common histopathological type of EAC cancer is squamous cell carcinoma. Verrucous carcinoma is a well-differentiated, low-grade variant of squamous cell carcinoma. It is a locally destructive, invasive, and slow growing tumor that rarely metastasizes. Verrucous carcinoma occurs predominantly in the oral cavity and larynx, and its occurrence in the EAC is extremely rare. In this report, we present a histologically confirmed case of verrucous carcinoma in the EAC and temporal bone, which for several years had been classified as epithelial hyperplasia. Two-and-a-half years after diagnosis of verrucous carcinoma, a recurrent mass was found and the lesion was then confirmed to be squamous cell carcinoma.
Carcinoma, Squamous Cell* ; Carcinoma, Verrucous* ; Diagnosis ; Ear Canal* ; Epithelial Cells* ; Head ; Hyperplasia ; Incidence ; Larynx ; Mouth ; Neck ; Temporal Bone

No abstract available.
Aged ; Biopsy ; Carcinoma, Verrucous/*diagnosis ; Diagnosis, Differential ; Eyelid Neoplasms/*diagnosis ; Eyelids/*diagnostic imaging ; Female ; Humans

Carcinoma, Verrucous ; diagnosis ; Humans ; Skull Base ; pathology

Carcinoma, Squamous Cell ; diagnosis ; Carcinoma, Verrucous ; diagnosis ; Epidermis ; pathology ; Humans

OBJECTIVE: To investigate the clinical, pathological character and differential diagnosis of laryngeal verrucous carcinoma. METHOD: Clinical data of one case with laryngeal verrucous carcinoma in our hospital were retrospectively analyzed. RESULT: The diagnosis of verrucous carcinoma was difficult and depend on repeated biopsy. Verrucous carcinoma of larynx is a highly differentiated variant of squamous carcinoma that has peculiar clinical and morphological features. The basement membrane is not invaded. It is prone to distant metastasis, than to local recurrence. The case underwent the partial laryngectomy, and was followed up for more than 4 years with no recurrence. CONCLUSION Verrucous carcinoma of the larynx is a special pattern of the well-differentiated squamous cancer. A correct diagnosis requires close cooperation between the laryngologist and the pathologist. The main treatment of verrucous carcinoma is complete surgical excision to reserve larynx function as far as possible and improve the quality of life.
Carcinoma, Verrucous ; diagnosis ; surgery ; Humans ; Laryngeal Neoplasms ; diagnosis ; surgery ; Male ; Middle Aged ; Retrospective Studies

Antigens, CD ; metabolism ; Antigens, Differentiation, Myelomonocytic ; metabolism ; Carcinoma, Verrucous ; pathology ; Condylomata Acuminata ; pathology ; virology ; Diagnosis, Differential ; Human papillomavirus 11 ; isolation & purification ; Humans ; Hyperplasia ; Male ; Middle Aged ; Penile Diseases ; metabolism ; pathology ; virology ; Penile Neoplasms ; pathology ; Penis ; pathology ; Xanthomatosis ; metabolism ; pathology ; virology

Carcinoma cuniculatum or verrucous carcinoma is an uncommon variant of squamous cell carcinoma. Its exact incidence is unknown. Literature search shows that there is no published report of this form of squamous cell carcinoma in local journals. This type of carcinoma occurs on the oral cavity, larynx, genitalia, skin and esophagus. The tumor has minimal metastatic potential. We report the case of an 84-year-old man with a six-month history of solitary erythematous plaque with ulceration extruding hemopurulent discharge on the right scrotal area and multiple erythematous plaques, some with slightly verrucous surfaces on the medial aspect of the right thigh, which rapidly enlarged. Histologic examination is compatible with squamous cell carcinoma. Final diagnosis with clinicopathologic correlation is carcinoma cuniculatum. Radiotherapy was started; however, patient expired. The importance of early diagnosis and treatment is emphasized to prevent mortality from verrucous carcinoma.

Human ; Male ; Aged 80 And Over ; Carcinoma, Squamous Cell ; Carcinoma, Verrucous ; Early Diagnosis ; Esophagus ; Genitalia ; Incidence ; Larynx ; Mouth ; Skin Neoplasms ; Thigh

Aged ; Biopsy ; Carcinoma, Verrucous ; diagnosis ; Diagnosis, Differential ; Humans ; Male ; Scalp ; Skin Neoplasms ; diagnosis

Anus Neoplasms ; diagnosis ; etiology ; surgery ; Buschke-Lowenstein Tumor ; Carcinoma, Verrucous ; diagnosis ; etiology ; surgery ; Condylomata Acuminata ; etiology ; pathology ; surgery ; Human papillomavirus 16 ; Human papillomavirus 18 ; Humans ; Male ; Middle Aged ; Papillomavirus Infections ; complications ; Penile Neoplasms ; etiology ; pathology ; surgery ; Time Factors