Objective: To evaluate the implementation process of a school-family collaborative "online+offline" tobacco control intervention program in junior high school in Beijing and to explore the execution status, influencing factors and sustainability potential of the intervention, so as to provide evidence for optimizing youth tobacco control strategies. Methods: In November 2024, using the random number table method, four first year junior high school classes were selected from three schools each in Fengtai District, Tongzhou District, and Fangshan District of Beijing. One class served as the control group, while the other three classes were designated as intervention groups (one each for online intervention, offline intervention, and combined online offline intervention). The control group received only conventional education.The online intervention group was engaged in WeChat push interventions, including watching micro videos, viewing promotional materials, participating in online quizzes and mini games; the offline intervention group attended knowledge lectures, played peer games, and participated in offline knowledge competitions; the combined online offline intervention group integrated all the aforementioned online and offline intervention measures. The intervention period was from November 2024 to June 2025, spanning a total of 7 months. Based on the Practical, Robust Implementation and Sustainability Model(PRISM) framework, a qualitative research design was employed to conduct semi structured interviews with 48 participants (12 in each of the intervention groups and 12 organizational staff members) from the Centers for Disease Control and Prevention (CDC) in 3 districts and 3 sampled schools. The interview outlines were designed according to the intervention plan. Data was managed using Nvivo 12.0 software and analyzed following Colaizzi s seven step phenomenological analysis method. Theoretical saturation was assessed using a reserved subset of transcripts. Results: Four core themes were identified in the tobacco control intervention process. Overall fidelity of intervention implementation was largely consistent with the original plan, and students showed strong willingness and positive evaluations toward interactive formats such as knowledge contests and peer games, though occasional breakdowns in school-family communication and blurred boundaries between online and offline components were observed; the participants showed a polarized response in terms of satisfaction and participation, most students and parents recognized the significance of the activity, and some parents observed a reduction in smoking behavior; the implementation of internal tobacco control policies in the school was strict, and the atmosphere was favorable, but there was still room for improvement, such as the scarcity of community tobacco control activities and the difficulty in implementing smoke free units; implementation and sustainability infrastructure were preliminarily established, such as through homeroom teacher supervision and training student assistants to assisted in activities, while the sustainability support system required further refinement. Conclusion The school-family collaborative "online+offline" tobacco control intervention has demonstrated significant positive effects, but further optimization of activity design, enhancement of community reward mechanisms, and standardized training are required to improve the efficacy and sustainability of the intervention.

Objective:To detect the increase in skeletal muscle mass after oral megestrol administration and its influence on the levels of four cytokines,analyze the relationship between cytokine expression and sarcopenia,and provide new insights for the management,curat-ive effect prediction,and early screening of lung cancer patients with sarcopenia. Methods:A total of 60 patients with lung cancer complic-ated by sarcopenia were recruited from The Central Hospital of Shaoyang between June 2023 and June 2024. They were randomly assigned into an experimental group (30 cases) and a control group (30 cases). Patient data,including age,sex,body mass index,skeletal muscle mass index (SMI),blood glucose,serum albumin,triglyceride levels,and the levels of four cytokines (IL-1β,IL-6,IFN-γ,and TNF-α),were recorded. The correlation between the four cytokines and sarcopenia was investigated after the intervention. Results:There was no significant differ-ence between the experimental and control groups except for the IL-1β level (P>0.05). The levels of the four cytokines decreased signific-antly on the 10th day of medication compared to days 10-25 (P<0.05). A positive correlation between the levels of the four cytokines at dif-ferent time points (P<0.05) was observed. After megestrol intervention,SMI values increased by 11.8％ from the baseline. Conclusions:Oral administration of megestrol can reduce the levels of cytokines IL-1β,IL-6,IFN-γ,and TNF-α while increasing the skeletal muscle mass to a certain extent. This suggests that megestrol may have positive therapeutic value in improving the prognosis and related clinical symptoms of patients with lung cancer and sarcopenia.

Objective:To detect the increase in skeletal muscle mass after oral megestrol administration and its influence on the levels of four cytokines,analyze the relationship between cytokine expression and sarcopenia,and provide new insights for the management,curat-ive effect prediction,and early screening of lung cancer patients with sarcopenia. Methods:A total of 60 patients with lung cancer complic-ated by sarcopenia were recruited from The Central Hospital of Shaoyang between June 2023 and June 2024. They were randomly assigned into an experimental group (30 cases) and a control group (30 cases). Patient data,including age,sex,body mass index,skeletal muscle mass index (SMI),blood glucose,serum albumin,triglyceride levels,and the levels of four cytokines (IL-1β,IL-6,IFN-γ,and TNF-α),were recorded. The correlation between the four cytokines and sarcopenia was investigated after the intervention. Results:There was no significant differ-ence between the experimental and control groups except for the IL-1β level (P>0.05). The levels of the four cytokines decreased signific-antly on the 10th day of medication compared to days 10-25 (P<0.05). A positive correlation between the levels of the four cytokines at dif-ferent time points (P<0.05) was observed. After megestrol intervention,SMI values increased by 11.8％ from the baseline. Conclusions:Oral administration of megestrol can reduce the levels of cytokines IL-1β,IL-6,IFN-γ,and TNF-α while increasing the skeletal muscle mass to a certain extent. This suggests that megestrol may have positive therapeutic value in improving the prognosis and related clinical symptoms of patients with lung cancer and sarcopenia.

Objective:To observe the urinary iodine content (UIC), breast milk iodine content (BMIC) and milk iodine excretion of lactating rats under different iodine nutrition levels, and to explore the iodine metabolism of the lactating rats under different iodine nutrition levels.Methods:Forty female Wistar rats with body weight ranging from 70 to 120 g were divided into low iodine (LI) group, normal iodine (NI) group, hight iodineⅠ (HIⅠ) group and hight iodine Ⅱ (HIⅡ) group according to body weight by random number table method, with 10 rats in each group. The rats were fed low-iodine diet, and the iodine ion concentration of drinking water in each group was 0, 325, 18 700 and 37 450 μg/L. Twenty male rats were fed according to the feed method of NI group. After 8 weeks of intervention, the male and female rats were caged and mated in a ratio of 1 ∶ 2. Milk and 24 h urine were collected on the 7th, 14th and 21st days of lactation (L7, L14 and L21), and the amount of food and drinking water consumed were recorded. The 24 h milk excretion was calculated by acute lactation test. UIC and BMIC were determined by inductively coupled plasma mass spectrometry (ICP-MS).Results:The 24 h total iodine intake of lactating rats in LI, NI, HIⅠ and HIⅡ groups were (1.84 ± 0.51), (30.51 ± 6.79), (765.95 ± 317.41) and (1 654.26 ± 560.55) μg/d, respectively. The difference between groups was statistically significant ( P < 0.001). At L7, L14 and L21, there were statistically significant differences in UIC, BMIC and milk iodine excretion at the same lactation stages among different groups ( P < 0.001). In HIⅡ group, the difference of BMIC and milk iodine excretion at different lactation stages (L7, L14, and L21) were significantly signrficant ( P < 0.05). The 24 h milk iodine excretion of LI, NI, HIⅠ and HIⅡ groups was (1.23 ± 0.85), (11.88 ± 5.23), (207.09 ± 114.51), (493.67 ± 242.47) μg, respectively. The proportion of 24 h milk iodine excretion to 24 h total iodine intake was 66.85%, 38.94%, 27.04% and 29.84%, respectively. Conclusions:About 39% of dietary iodine is supplied to offspring through milk when iodine nutrition is normal. The iodine excretion ratio of milk is increased or decreased with low and high iodine levels. These results indicate that lactating rats with different iodine nutrition levels can regulate the ratio of iodine excretion in milk through their own compensatory effect to reduce the influence of iodine deficiency and iodine excess on their offspring.

Objective To study the improvement of hemorheology and prognosis of cervical spondylosis by Tongmai Dingxuan Decoction combined with Manipulation.MethodsA total of 106 patients with cervical spondylopathy in our hospital from November 2014 to November 2015 were randomly divided into observation group and control group,with 53 cases in each group.The control group were treated with manipulation,the observation group was treated with Tongmai Dingxuan Decoction combined with manipulation.The changes of hemorheology parameters such as high blood viscosity, whole blood low shear viscosity, plasma viscosity, whole blood reduction viscosity, hematocrit, erythrocyte aggregation index, fibrinogen were compared between the two groups before and after treatment.The two groups of patients were observed for a one-year follow-up, one year recurrence rate were compared.ResultsThe total effective rate was 92.45% in the observation group was significantly higher than that in the control group 77.36% (P<0.05).The whole blood low shear viscosity (7.01±1.52) mPa·s, the whole blood viscosity (1.18±0.28) mPa·s, fibrinogen (3.91±0.94) g/L were significantly lower than those in the control group (7.88±1.65) mPa·s, (1.47±0.34) mPa·s, (4.51±0.98) g/L (P<0.05).The recurrence rate in the observation group was 13.21%, which was significantly lower than that in the control group (30.19%) (P<0.05).ConclusionTongmai Dingxuan Tang combined with manipulation in the treatment with cervical spondylosis is significant, the whole blood viscosity is reduced, blood circulation function is improved, the recurrence rate after treatment is low, which is worthy of clinical application.

OBJECTIVETo evaluate the reliability and validity of SF-36 scale in urban residents, and provide reference for the selection of suitable health measure tools for urban residents.

METHODSMulti-stage cluster stratified sampling was conducted to select the residents aged ≥18 years in three urbanized communities of Hangzhou. SF-36 scale was used for the measurement of the quality of life and Spearman-Brown and Cronbach' s α coefficients were used for the evaluation of split-half reliability and internal consistency reliability. The convergent and discriminative validity were evaluated by using the success rate of experiments and the criterion-related validity was evaluated with correlation analysis and non-parameter test. Structural equation modeling was used in the evaluation of contract validity.

RESULTSSF-36 scale had good split-half reliability (R=0.94) and internal-consistency reliability (except for bodily pain and vitality, Cronbach's α range: 0.70-0.91). The convergent validity (88.57%), discriminate validity (successful rates 90.61%) and the criterion-related validity (γs=0.56, the score was consistent with the self-reported health status) were good. Second-order confirmatory factor analysis model was not well-fitted (GFI= 0.721, AGFI= 0.682, CFI= 0.731, RMR= 0.084, RMSEA= 0.098), indicating that the construct validity was poor.

CONCLUSIONThe reliability, consolidation validity, discrimination validity and criterion-related validity of SF-36 scale were good, while the construct validity was poor. Improvement is needed when the scale is used for urban residents.

Factor Analysis, Statistical ; Health Status ; Humans ; Quality of Life ; Reproducibility of Results ; Self Report ; Surveys and Questionnaires ; Urban Population