Objective To explore the perioperative therapeutic effects and follow-up manage-ment in 16 patients with left ventricular assist device(LVAD)implantation.Methods A retrospec-tive analysis was conducted in data of 16 patients who underwent LVAD implantation in the depart-ment of cardiovascular surgery.Data of 6-minute walk test(6MWT),European Quality of Life-5 Di-mension-5 Levels(EQ-5D-5L),New York Heart Association(NYHA)classification,echocardio-graphy,chest radiography,cardiothoracic ratio,and occurrence of complications(infection,bleed-ing,thrombosis,right heart failure,neurological issues)were collected via the electronic medical re-cord system before surgery and at 30,60,and 90 days postoperatively.Results All patients sur-vived with the pump at 90 days postoperatively.One patient with preoperative renal insufficiency un-derwent dialysis and received a heart transplant after 8 months.One patient developed a sterile granu-loma at the percutaneous lead site on the abdominal wall,which improved after treatment,no complica-tions occurred in other patients.At 90 days postoperatively,there was no statistically significant differ-ence in the right ventricular area change fraction and tricuspid annular plane systolic excursion com-pared with preoperative values(P＞0.05).The left ventricular ejection fraction,left ventricular end-diastolic diameter,and cardiothoracic ratio showed significant improvement compared with preoperative levels(P＜0.05).At 30 days postoperatively,30％of patients recovered to NYHA class Ⅰ and 70％to class Ⅱ;at 60 days,80％of patients to class Ⅰ and 20％to class Ⅱ;at 90 days,90％to classⅠ and 10％to class Ⅱ.The 6MWT and EQ-5D-5L scores of patients significantly increased within 90 days postoperatively(P＜0.01).Conclusion Through rigorous preoperative assessment by a multidisciplinary LVAD team,refinement of surgical techniques,and comprehensive management during hospitalization,self-management before discharge,daily follow-up after discharge,and fol-low-up management upon returning to the hospital for patients with LVAD implantation,the cardiac function and quality of life of patients are significantly improved at 90 days postoperatively.

Objective:To explore the pregnancy outcome of intracytoplasmic sperm injection (ICSI)/rescure-ICSI (Re-ICSI) patients with gear-like transparent dense zona pellucida and small perivitelline oocytes.Methods:Totally 6 couples with abnormal zona pellucida came to the Reproductive Medicine Center of Shijiazhuang the Fourth Hospital from January 2015 to June 2020 were retrospectively case control analyzed. A total of 8 cycles had zona pellucida abnormalities, of which 5 couples, the proportion of M I oocytes was ≥50% (part oocytes M I arrest) in 6 cycles and 1 couple (2 cycles) was all oocytes M I arrest. ICSI or in vitro fertilization (IVF) short-term fertilization was performed on M II oocytes with abnormal zona pellucida in controlled superovulation, IVF short-time fertilization failed completely, and Re-ICSI was performed. M I oocytes were performed ICSI/Re-ICSI simultaneously. The ICSI/Re-ICSI fertilization rate, degeneration rate, cleavage rate, high-quality embryo rate and blastocyst rate were compared between the two groups of M II oocytes and M I oocytes, as well as all oocytes M I arrest and part oocytes M I arrest groups, respectively. Results:Totally 37 M II oocytes and 65 M I oocytes underwent ICSI/Re-ICSI. M I oocytes fertilization and 2PN fertilization rates were lower than M II oocytes [46.2%(30/65) vs. 89.2% (33/37); 32.3% (21/65) vs. 83.8% (31/37), all P<0.001]. Both groups had high-quality embryos and blastocyst formation. Compared with part oocytes M I arrest and all oocytes M I arrest, there was no statistical difference in fertilization rate, degeneration rate, high-quality embryo rate and blastocyst formation rate between the two groups (all P>0.05). Conclusion:ICSI/Re-ICSI for patients with abnormal zona pellucida with a high proportion of M I oocytes can increase the patients' oocytes utilization rate and available embryos.

Objective:To explore the pregnancy outcome of intracytoplasmic sperm injection (ICSI)/rescure-ICSI (Re-ICSI) patients with gear-like transparent dense zona pellucida and small perivitelline oocytes.Methods:Totally 6 couples with abnormal zona pellucida came to the Reproductive Medicine Center of Shijiazhuang the Fourth Hospital from January 2015 to June 2020 were retrospectively case control analyzed. A total of 8 cycles had zona pellucida abnormalities, of which 5 couples, the proportion of M I oocytes was ≥50% (part oocytes M I arrest) in 6 cycles and 1 couple (2 cycles) was all oocytes M I arrest. ICSI or in vitro fertilization (IVF) short-term fertilization was performed on M II oocytes with abnormal zona pellucida in controlled superovulation, IVF short-time fertilization failed completely, and Re-ICSI was performed. M I oocytes were performed ICSI/Re-ICSI simultaneously. The ICSI/Re-ICSI fertilization rate, degeneration rate, cleavage rate, high-quality embryo rate and blastocyst rate were compared between the two groups of M II oocytes and M I oocytes, as well as all oocytes M I arrest and part oocytes M I arrest groups, respectively. Results:Totally 37 M II oocytes and 65 M I oocytes underwent ICSI/Re-ICSI. M I oocytes fertilization and 2PN fertilization rates were lower than M II oocytes [46.2%(30/65) vs. 89.2% (33/37); 32.3% (21/65) vs. 83.8% (31/37), all P<0.001]. Both groups had high-quality embryos and blastocyst formation. Compared with part oocytes M I arrest and all oocytes M I arrest, there was no statistical difference in fertilization rate, degeneration rate, high-quality embryo rate and blastocyst formation rate between the two groups (all P>0.05). Conclusion:ICSI/Re-ICSI for patients with abnormal zona pellucida with a high proportion of M I oocytes can increase the patients' oocytes utilization rate and available embryos.

Objective To explore the influences of the network medical health management on the coping styles , hope level and quality of life in patients with primary kidney cancer surgery .Methods The patients of control group received normal health management and the participants included 77 kidney cancer patients who were laboratory diagnosed during March 2011 and September 2012 .The patients of intervention group received the network medical health management based on the normal health management and the participants included 79 kidney cancer patients who were laboratory diagnosed during March 2013 and September 2014 .The coping styles , hope level and quality of life before and after the intervention were compared between the two groups .Results Before the intervention , the coping styles and the hope level had no statistical differences between the two groups (P>0.05).After the intervention for the coping styles , the intervention group had higher scores of the positive coping style (25.44 ±2.61) and lower scores of the negative coping style (9.76 ±1.89) and presented statistical differences compared with that of the control group ( t=-10.468, 7.572;P <0.01).For the hope level, there was no statistical significance between two groups before intervention (P >0.05); however, after intervention, the intervention group had higher scores of positive attitudes (14.5 ±2.6), positive behaviors (15.1 ±2.4) and close contact with people (15.6 ±2.1), and presented statistical differences with that of the control group (t=4.965, 5.569, 4.965; P<0.05).For the quality of life, there were no statistical differences for the dimensions of PF , RF and DY (P>0.05) but the intervention group performed better on other 12 dimensions′scores ( P <0.05 ); the quality of life in the intervention group was better than that of control group .Conclusions The network medical health management should be further applied to the clinical practice , because it can significantly improve the coping styles , hope level and quality of life among the patient with primary kidney cancer surgery .

Objective To investigate the effects of application of problem-based learning (PBL) education in primary renal cell carcinoma surgical patients.Methods A total of 1 00 renal cell carcinoma patients who received surgical treatments from July 201 3 to January 201 5 in Cancer Hospital Affiliated to Zhengzhou University were randomly divided into control group (50 cases)and observation group (50 cases). The patients in control group received routine health education and the patients in observation group received PBL health education.The psychological status,satisfaction with nursing and occurrence of postoperative complications were compared in two groups when admitted and discharged from hospital.Results The difference of psychological status in two groups was not significant when admitted hospital (P >0.05),while it is better in observation group when discharged from hospital (P <0.05).In addition,the degree of satisfaction was higher in observation group (P <0.05).Furthermore,the occurrence of complications was lower in observation group (P <0.05).Conclusions Health education based on PBL can arouse patients′enthusiasm in actively learning disease-related knowledge, improve their psychological status, decrease the occurrence of postoperative complications and increase patients′satisfaction.