Objective:To investigate the characteristics of attention bias to aggressive information under self-threat priming in college students with different types of high self-esteem.Methods:A total of 650 college students were selected,and high self-esteem participants were selected through the Self Esteem Scale(SES).Then,43 partic-ipants were selected from different types of high self-esteem(fragile and safe)groups through the Implicit Associa-tion Test(IAT).Each group participated in Raven's Standard Progressive Matrices(SPM)with different difficulty levels to complete self-threat priming,and then completed the spatial cue experiment.When the cue was invalid,the attention bias was obtained according to the variation of the reaction time difference(RTI)between the subjects're-sponses to aggressive words and neutral words.Results:The RTI values of the fragile high self-esteem group were higher under high self-threat priming than that of the secure high self-esteem group(P＜0.01).Under low self-threat priming,there was no significant difference in RTI values among different types of high self-esteem groups(P＞0.05).Conclusion:Fragile high self-esteem group are more likely to develop attention bias towards aggressive words under high self-threat priming than that of secure high self-esteem group.

Background::The pharmacokinetic and clinical behaviors of many proton pump inhibitors (PPIs) in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms. This non-inferiority study evaluated the efficacy and safety of the novel PPI anaprazole compared with rabeprazole. We also explored the influence of Helicobacter pylori ( H. pylori) infection status and CYP2C19 polymorphism on anaprazole. Methods::In this multicenter, randomized, double-blind, double-dummy, positive-drug parallel-controlled, phase III study, Chinese patients with duodenal ulcers were randomized 1:1 to receive rabeprazole 10 mg + anaprazole placebo or rabeprazole placebo + anaprazole 20 mg once daily for 4 weeks. The primary efficacy endpoint was the 4-week ulcer healing rate assessed by blinded independent review. Secondary endpoints were the proportion of patients with improved overall and individual duodenal ulcer symptoms at 4 weeks. Furthermore, exploratory subgroup analysis of the primary endpoint by H. pylori status and CYP2C19 polymorphism was conducted. Adverse events were monitored for safety. Non-inferiority analysis was conducted for the primary endpoint. Results::The study enrolled 448 patients (anaprazole, n = 225; rabeprazole, n = 223). The 4-week healing rates were 90.9% and 93.7% for anaprazole and rabeprazole, respectively (difference, -2.8% [95% confidence interval, -7.7%, 2.2%]), demonstrating non-inferiority of anaprazole to rabeprazole. Overall duodenal ulcer symptoms improved in 90.9% and 92.5% of patients, respectively. Improvement rates of individual symptoms were similar between the groups. Healing rates did not significantly differ by H. pylori status or CYP2C19 genotype for either treatment group. The incidence of treatment-emergent adverse events was similar for anaprazole (72/220, 32.7%) and rabeprazole (84/219, 38.4%). Conclusions::The efficacy of anaprazole is non-inferior to that of rabeprazole in Chinese patients with duodenal ulcers.Registration::ClinicalTrials.gov, NCT04215653.

Hepatectomy is a common surgical procedure for hepatic surgeries, and due to its high complexity, the mortality rate after hepatectomy is as high as 30%. As one of the most common postoperative complications, posthepatectomy liver failure (PHLF) directly affects the disease-free survival and overall survival of patients after hepatectomy. Although there are great improvements in liver surgeries in the past ten years, PHLF cannot be avoided due to the condition and liver reserve function of patients before surgery. Although current techniques can significantly reduce the mortality rate of PHLF and bring more opportunities to patients, how to effectively evaluate the risk of PHLF and guide prevention and treatment strategies is still a major concern of liver surgeons. This article reviews the recent research on PHLF, including the definition, risk factors, preoperative evaluation, and prevention and treatment of PHLF, so as to provide a reference for reducing PHLF and performing effective treatment.

Objective To explore the effects of hospital-home-nursing(HHN) trinity model in the patients with malignant tumor of digestive system in the advanced stage.Methods Totally 110 patients with advanced tumor were selected and equally divided into an observation group (from October 2015 to June 2016) and a control group (from January 2015 to September 2015) based on the admission date. The patients in the control group received conventional terminal nursing and psychological nursing, while the patients in the observation group received nursing with the HHN trinity model on this basis. Then the psychological distress and meaning of life were compared between the patients in the two groups.Results One month after they were discharged from hospital, the patients in the observation group were scored (5.94±2.13) for psychological distress, lower than (7.03±2.27) of the patients in the control group (t=-2.296,P=0.020). The family members of the patients in the observation group were scored (5.22±1.83) for psychological distress, lower than (6.48±1.54) of the patients in the control group (t=-2.247,P=0.023). And the patients in the observation group were scored higher in the dimensions of meaning of life, misery bearing and death acceptance than the patients in the control group (t=2.095, 2.806, 2.260;P<0.05).Conclusions The HHN trinity model which integrates the forces of the hospital, nurses and family members for treatment, home and psychological nursing, can solve the real problems of patients, improve their quality of life, and better achieve the nursing objectives for patients with advanced tumor.