Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.
Aged ; Anticonvulsants ; Carbamazepine ; Humans ; Male ; Phenobarbital ; Phenytoin ; Skin ; Stevens-Johnson Syndrome*

PURPOSE: To evaluate the effectiveness of MR imaging in assessing the response of carcinomas of the uterinecervix to the combined therapy of interferon alpha-2a, 13-cis-retinoic acid and radiation. MATERIALS AND METHODS: Thirteen patients with untreated, locally advanced squamous cell cervical carcinoma were treated for eight weeks with 13-cis-retinoic acid plus interferon alpha-2a and radiotherapy. Axial and sagittal T1-weighted spin echo and fast spin echo MR images were obtained before and after treatment, using a 1.5-T MR scanner. MR images were correlated with biopsy findings. In each patient, pre- and post-treatment images were prospectively analyzed andcompared. RESULTS: In all patients, tumor volume could be calculated by three dimensional measurement on MR images. Initial response to the combined therapy was complete in eight patients, partial in four and progressivein one. Evidence of tumor recurrence was noted in two patients during the follow-up period. MR images correlated well with biopsy findings. CONCLUSION: MR imaging is useful in the evaluation of tumor response to the combined biologic and radiation therapy, which can be an effective first-line therapy against locally advanced squamouscell carcinoma of the cervix.
Biopsy ; Carcinoma, Squamous Cell* ; Cervix Uteri* ; Female ; Follow-Up Studies ; Humans ; Interferons* ; Isotretinoin ; Magnetic Resonance Imaging ; Prospective Studies ; Radiotherapy ; Recurrence ; Tumor Burden

Acute suppurative cholangitis is a severe inflammatory process of the bile duct occurred as a result of partial or complete obstruction of the bile duct, and may manifest clinically severe from of disease, rapidly deterioration to life-threatening condition. We analyzed emergency percutaneous transhepatic biliary drainage in 20 patients of acute suppurative cholangitis with biliary sepsis to evaluate the therapeutic effect and complication of the procedure. The underlying causes were 12 benign diseases(stones) and eight malignant tumors and among eight malignant tumors, bile duct stones(n=4) and clonorchiasis (n=1) were combined. Percutaneous transhepatic biliary drainage was performed successfully in 17 of 20 patients improvement of general condition and failed in three patients. The procedures were preterminated due to the patient's condition in two and biliary-porto fistula was developed in one. After biliary decompression by percutaneous transhepatic biliary drainage, effective and successful elective surgery was performed in nine cases, which were seven biliary stones and two biliary cancer with stones. Our experience suggests that emergency percutaneous transhepatic biliary drainage is an initial and effective treatment of choice for acute suppurative cholangitis with sepsis and a safe alternative for nonsurgical treatment.
Bile Ducts ; Cholangitis* ; Clonorchiasis ; Decompression ; Drainage* ; Emergencies ; Fistula ; Humans ; Sepsis*

We retrospectively evaluated the characteristic computed tomographic (CT) findings in nine patients with exohepatic hepatocellular carcinoma(HCC) pathologically prove by surgery(n=2) or percutaneous needle biopsy(n=7). The CT findings of exohepatic HCC were correlated with clinical findings and compared with those of usual HCC Lesions were in the left lobe lobe(n=7) and right lobe(n=2) of the liver. All lesions showed a well-marginated hypodense mass with capsular enhancement on enhanced CT scan. The patterns of capsular enhancement were complete in five and partial in four cases. The portal vein thrombosis was seen only in one case. There was no difference between exohepatic HCC and usual HCC in clinical findings such as increased α-fetoprotein(α-FP), positive Hepatitis B surface antigen(HBsAg), and underlying liver cirrhosis. In conclusion, the CT findings of exohepatic HCC were a well-defined hypodense mass with complete or partial capsular enhancement and these findings may be useful in differentiation from the tumors of adjacent organs.
Carcinoma, Hepatocellular* ; Hepatitis B ; Humans ; Liver ; Liver Cirrhosis ; Needles ; Retrospective Studies ; Tomography, X-Ray Computed ; Venous Thrombosis

No abstract available.
Stomach Neoplasms* ; Stomach* ; Water*

No abstract available.
Carotid Artery, Internal*

Spinal tuberculosis is curable disease, and early diagnosis is mandatory for early treatment. We reviewedconventional radiographies and CT from Histopathologically confirmed 30 cases of spinal tuberculosis, and comparedthese findings with radiologic findings from 2 cases of pyogenic spondylitis and 4 cases of meastasis. The resultswere as follows: 1. The frequnet site of involvement were thoracolumbar juntion and low lumbar vertebrae, and themost frequent type is multisegmented subligamentous type (93.3%). 2. CT was not of great use in the diferentaldiagnosis of the tuberculosis. Dominant CT findings of tuberculous spondylitis were anterior vertebral bodydestruction, paravertebral soft-tissue mass and thick walled abscess formation occasionally containingcalcification and disc space narrowing, in the setting of an indolent or relatively benign course. 3. CT is thebest modality for imaging the extent and anatomy of the destructive process, the degree of canal encroachment, andthe change of adjacent vital structure. So CT was particularily useful in pre-operative planing of debridement andstabilization surgery. 4. The most common causes of neurologic manifestations in tuberculous spondylitis were thecompression of spinal cord by sequestrated bony fragments and disc material, granulation tissue or abscess in thespinal canal.
Abscess ; Debridement ; Early Diagnosis ; Granulation Tissue ; Lumbar Vertebrae ; Neurologic Manifestations ; Spinal Cord ; Spondylitis ; Tuberculosis ; Tuberculosis, Spinal

We have analyzed utrasonographic finding of 55 cases of hydronephrosis and 34 cases of renal maasses. The results are as follows; 1. 55 cases of hydronephrosis revealed renal enlargement in 55 cases, separation of central echo complex in 27 cases, multiple anechoic areas radiating from the center in 25 cases and dilated renalpelvis in 24 cases. 2. Among the renal masses in 34 cases, simple renal cyst were 15 cases, polycystic kidney in 8 cases, hypernephroma in 8 cases, Wilms' tmor in 2 cases and angiomyolipoma in 1 case. 3. Simple renal cystrevealed single in 14 cases (93%) and well defined anechoic mass with posterior enhancement in all cases. 4. Polycystic kidney revealed bilateral irregular shaped renal enlargement and multiple anechoic cysts throughout the kidney. 2 cases (25%) involved liver. 5. 6 cases (75%) of hypernephroma revealed ill defined modarately echogenicmass without posterior enhancement. 6. All cases of Wilms' tumor revealed well defined large mixed echogenic massin right kidney. 7. Angiomyolipoma revealed bilateral dense echogenic mass with large hemorrhagic cyst in rightkidney. 8. The ultrasonography is useful noninvasive diagnostic modality of evaluation of renal masses and hydronephrosis.
Angiomyolipoma ; Carcinoma, Renal Cell ; Hydronephrosis ; Kidney ; Liver ; Polycystic Kidney Diseases ; Ultrasonography ; Wilms Tumor

The authors reviewed serial chest films of 113 patients of spontaneous pneumothorax which were treated byclosed tube thoracotomy during the period from May, 1979 till July, 1982 in CNUH. The resuls are as follows; 1.Male was more frequently affected than female, and the sex ratio was 3.5:1. 2. 71.1 per cent of patients were over31 years of age. 3. Of the 113 cases, 51.3 per cent were on the right, 48.7 per cent on the left. 4. The mostcommon underlying pulmonary disease was pulmonary tuberculosis(39.8), the next was belb or bullar (17.7%), and thelast was pneumonia(8.8%). 5. Pneumothorax was the most common type in pulmonary tuberculosis(66.7%), andpyopneumothorax in pneumonia(80.0%). 6. Among 103 cases in complete re-expansion of collapsed lung after closedthe thoracotomy, 39.5 per cent was expanded completely within 1 week in presence of visceral and/or parietalpleural thickening, and 86.2 per cent in none of it. According to the degree of pneumothorax, the more severedegree of pneumothorax, the more delay in re-expansion times. 7. Most common chest finding after re-expansion ofcollapsed lung was pleural thickening(51.4%).
Female ; Humans ; Lung ; Lung Diseases ; Pneumothorax ; Sex Ratio ; Thoracotomy ; Thorax

The radiologic findings of lumbosacral spine and measurement of lumbosacral angle were analysed in 238 with backache and 102 without backache which were visited at Chungnam National University from March 1980 to July 1981.The measurement of lumbosacral angle was based on a method of Fergson. The results obtained were as follows; 1. The age group of 18 to 29 years was most common in backache group and the male was affected more frequently than the female with the ratio of 1.9 to 1. 2. In patients with backache, the overall mean lumbosacral angles were 44.2±2.6 degrees in male and 35.8±2.0 degrees in female. In patients without backache, in control group, the overall mean lumbosacral angles were 32.6±0.7 degrees in male and 33.4±1.4degrees in female. 3. In control group, difference of means between male and female was about 1degrees in patients with backache, the overall mean lumbosacral angles were increased about 12degrees in male and 2degrees in female than control group. In patients with and without backache, no significant difference of lumbosacral angle between the 4 age groups was present. 4. In backache group, increased lordosis was more common and increased lumbosacral angle than the decreased lordosis. 5. In backache group, lumbosacral angle of abnormal radiologic findings in lumbosacral spine was significantly increased than control group. 6. In patients with backache, radiologic findings and its lumboscral angles were alumbosacral anomaly 56 cases (23.5%): 46.9 degrees, increased lumbar lordosis 46 cases (19.2%): 48.1 degrees, osteoarthritis 44 cases(18.5%) : 40.8 degrees, decreased lumbar lordosis 30 cases (12.6%): 29.9 degrees, in order, And these radiologic findings were similar with many other authors.
Animals ; Back Pain ; Chungcheongnam-do ; Female ; Humans ; Lordosis ; Male ; Methods ; Osteoarthritis ; Spine