Background: Allergic and atrophic forms of chronic rhinitis are common among the population, characterized by a chronic progressive course with a tendency toward increasing prevalence. Worldwide, allergic rhinitis affects approximately 10–40% of adults and 2–25% of children. According to a study conducted in Mongolia, the prevalence of allergic rhinitis among adults in Ulaanbaatar was reported to be 23.6%, with an increasing trend anticipated in the future. In allergic and atrophic rhinitis, structural alterations occur in the nasal mucosa, including disruption of the normal architecture of the pseudostratified epithelium and ciliated cells, accompanied by changes in goblet cell number and dysfunction of their activity, resulting in a complex pathological process. In otorhinolaryngology practice in Mongolia, there is a relative lack of studies investigating the ultrastructural changes of the nasal mucosa in allergic and atrophic rhinitis. Aim: To compare ultrastructural and histological changes of the nasal mucosa in allergic and atrophic rhinitis. Materials and Methods: Ethical approval was obtained from the Research Ethics Review Committee of the Mongolian National University of Medical Sciences at the meeting held on April 24, 2020 (Protocol No. 2020/З-04). Appropriate ethical permission was also obtained from the EMJJ ENT Hospital. Nasal mucosal tissue samples were collected from surgically resected specimens of patients aged 20–45 years diagnosed with allergic and atrophic rhinitis. The mucosal specimens were processed at the Institute of Biomedical Sciences of the Mongolian National University of Medical Sciences. Samples were fixed and dehydrated according to the protocol, coated with 100 Å gold, and examined using a scanning electron microscope (FEI Quanta FEG 250, USA). In addition, paraffin blocks were prepared, sectioned at 4 μm thickness, stained with Hematoxylin and Eosin, and analyzed histologically. Results: In allergic rhinitis, the pseudostratified epithelium was relatively preserved; however, disorganization of ciliated cells, partial loss of cilia, and goblet cell hyperplasia were observed. In contrast, atrophic rhinitis showed epithelial thinning, near-complete loss of ciliated structures, glandular atrophy, and submucosal fibrosis. Conclusion Allergic rhinitis is associated with relatively mild and predominantly functional mucosal alterations, whereas atrophic rhinitis demonstrates severe structural damage with irreversible impairment of mucosal protective function.

Background: Choriocarcinoma is an aggressive trophoblastic malignancy characterized by rapid progression and a strong tendency for early hematogenous metastasis. It may occur in gestational or nongestational forms. Nongestational choriocarcinoma is extremely rare and is most commonly reported in young women. The tumor frequently metastasizes early to organs such as the lungs, liver, and brain. Case presentation: We report the case of a 21-year-old woman who presented with dyspnea and hemoptysis and was initially treated for pneumonia. Further evaluation revealed nongestational choriocarcinoma with pulmonary and hepatic metastases. Diagnosis: Contrast-enhanced computed tomography of the chest initially suggested pulmonary artery thromboembolism; however, the diagnosis was ultimately confirmed by histopathological examination. Conclusion The distinctive feature of this case is that the disease presented with clinical and radiological findings mimicking pulmonary artery thromboembolism. This case highlights the importance of considering metastatic choriocarcinoma in young women presenting with unexplained respiratory symptoms, hemoptysis, and atypical pulmonary vascular findings.

Background: Central serous chorioretinopathy (CSCR) is described by researchers as a condition that results from fluid under the retinal pigment epithelium, originating from the choroid of the eye. This disease usually affects the central part of vision and may resolve on its own over time, though in some cases, it can persist for long periods or recur. In our country, there is a lack of research regarding this condition, which led to the motivation for gathering and reviewing existing works on this topic. Aim: To collect and analyze a review of the studies on central serous chorioretinopathy (CSCR). Methods: We reviewed and analyzed literature related to CSCR published in electronic sources such as Thomson Reuters, PubMed-central database, and Google Scholar using literature review methods. Results: CSCR is most commonly seen in individuals aged 35-55 years, with a significantly higher prevalence in men (9.9/100,000) compared to women (1.7/100,000). Researchers found that the prevalence of CSCR is nearly the same among populations in Europe, Africa, and Asia. CSCR typically affects one eye, but it occurs in both eyes in up to 40% of cases. Weenink A (2001) studied the family members of 27 patients with bilateral CSCR, finding that 52% of family members had been diagnosed with CSCR, and 27.5% of them had chronic CSCR in at least one eye. This suggests a potential genetic predisposition to CSCR. According to researchers, while CSCR can be diagnosed clinically, additional imaging techniques like fluorescein angiography and optical coherence tomography are frequently used to rule out other diagnoses and guide treatment. Conclusion CSCR generally has a favorable prognosis, but recurrences and its effects on visual function indicate the need for effective management strategies. To maintain long-term visual improvement, it is essential to provide healthcare services tailored to the patient’s specific conditions and risk factors.

Background: However kidney transplantation has being performed in Mongolia since 2006, because of pre-transplant sensitization, ABO incompatibility, hepatitis B and C virus activation many patients are taken kidney transplantation in abroad. The transplantation centers use own immunosuppressive regimens. Objective: Our aim was to assess the immunosuppressive regimens efficacy and toxicity in kidney transplant Mongolian recipients. Methods: We analyzed data from 96 adult kidney transplant recipients who had taken kidney transplantation in different transplant centers from August 2006 through January 2014. There were 3 kinds of regimens Group I Simulect induction with standard triple /FK506/CyA+MMF/AZA+steroid/, Group II Campath-1H induction with CNI monotherapy and Group III Campath-1H induction with standard triple /FK506/CyA+MMF/AZA+steroid/. We retrospectively collected the post-transplant first two years serum creatinine. The study was performed in 2014. The questionnaire was taken and blood samples collected for determination of tacrolimus through level and for other laboratory tests. The primary end point was the first two years serum creatinine, the secondary end points included rejection episodes, blood through level of tacrolimus and some laboratory findings. Results: The post-transplant first two years serum creatinine levels were significantly different in 3 groups. Group III showed similar results compared to Group I. There was not enough data of biopsy proven acute rejection episodes however group II said more rejections occurred. However participants said that rejection occurred in 15 (15.6%) biopsy was done only 3 (3.1%) cases. Blood through level of tacrolimus was significantly different in three groups. Some laboratory findings showed different between three groups. Conclusions A regimen of Campath-1H induction with CNI monotherapy (Group II) may be advantageous for short-term renal function and cost effective but there were more rejection complications and increased creatinine. The regimen of Campath-1H induction 11 with standard triple (Group III) may be advantageous for long-term renal function, allograft survival, but there should consider about infection complications and polycythemia. Simulect induction with standard triple could be best choice but transplantations were performed in experienced centers. The study enrolled few cases and cases which were performed at the beginning of transplant program so many things could influence on the result. The study was compared beginner transplant center with experienced centers. Longitudinal cohort study needed in the future.