Background: MUTYH-associated polyposis is an autosomal recessive disorder associated with an increased lifetime risk of colorectal cancer and a moderately increased risk of ovarian, bladder, breast, and endometrial cancers. We analyzed the carrier frequency and estimated the incidence of MUTYH-associated polyposis in East Asian and Korean populations, for which limited data were previously available. Methods: We examined 125,748 exomes from the gnomAD database, including 9,197 East Asians, and additional data from 5,305 individuals in the Korean Variant Archive and 1,722 in the Korean Reference Genome Database. All MUTYH variants were interpreted according to the American College of Medical Genetics and Genomics and Association for Molecular Pathology guidelines and the Sequence Variant Interpretation guidelines from ClinGen. Results: The global carrier frequency of MUTYH-associated polyposis was 1.29%, with Europeans (non-Finnish) having the highest frequency of 1.86% and Ashkenazi Jews the lowest at 0.06%. East Asians and Koreans had a carrier frequency of 0.35% and 0.37% and an estimated incidence of 1 in 330,409 and 1 in 293,304 in Koreans, respectively, which were substantially lower than the global average of 1 in 24,160 and the European (nonFinnish) incidence of 1 in 11,520. Conclusions This was the first study to investigate the frequency of carriers of MUTYH-associated polyposis in East Asians, including specific subgroups, utilizing gnomAD and a Korean genome database. Our data provide valuable reference information for future investigations of MUTYH-associated polyposis to understand the genetic diversity and specific variants associated with this condition in East Asian populations.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.

Purpose: To identify influencing factors of media literacy, perceived neighborhood disorder, and adult attachment styles on fear of crime in adults in their 30s. Methods: Subjects were 232 adults in their 30s residing in South Korea. Data were collected through online and mobile surveys from February 21 to 26, 2024. Results: The following factors were found to significantly influence general fear of crime: female (β=.29, p<.001), perceived neighborhood disorder (β=.22, p=.002), attachment anxiety (β=.19, p=.003), and exclusion harmful media (β=.14, p=.020). These factors explained 23% of general fear of crime in adults in their 30s. The following factors significantly influenced specific fear of crime: perceived neighborhood disorder (β=.33, p<.001), attachment anxiety (β=.29, p<.001), female (β=.17, p=.003) and daily video platform usage (β=.16, p=.045). These factors explained 32% of specific fear of crime in adults in their 30s. Conclusion A multidimensional approach to understanding influencing factors of fear of crime is necessary because such an approach can serve as a basis for future public safety policies. Community mental health nurses should also increase their focus on ensuring that citizens feel safe in their communities.