PURPOSE: The target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis. MATERIALS AND METHODS: We conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis, and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry. RESULTS: Patients in group 3 showed statistically significantly elevated calciuria (15.4 mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups. CONCLUSIONS: Recurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.
Bone Density ; Bone Resorption ; Calcium ; Cross-Sectional Studies ; Fasting ; Female ; Humans ; Lithiasis ; Nephrolithiasis ; Urolithiasis

Bone formation in the urinary tract is a rare phenomenon. Osseous metaplasia in the kidney which presented as a pelvolithiasis is presented in this case. The patient consulted with a complaint of left subcostal mass. Ultrasound revealed nephrolithiasis with hydronephrosis of the left kidney while CT stonogram revealed staghorn calculus with hydronephrosis. Subsequently, left nephrectomy was performed. Grossly, the kidney was enlarged to 11.5m x 5cm x 3cm on cut section with an intrarenal mass measuring 7cm x 6.5cm x 6cm composed of tan gray irregular hard tissue. Histopathologically, the renal mass consisted of benign compact and cancellous bone wherein osseous metaplasia was considered.
Osseous Metaplasia ; Heterotopic Bone Formation ; Bone Lithiasis ; Nephrolithiasis