Objectives: This qualitative study explores the perspectives of dental hygienists and examines factors influencing payment structures in a community home-based oral health care intervention program. Methods: Focus group interviews were conducted on October 26, 2023, in a quiet study room over 120 minutes. Intervention providers who participated in the older adults medical care integration support program were included in this study. Their ages ranged from 25 to 57 years, with experience in home-based oral healthcare spanning from 1.5 to 5 years. Voice recordings of the interviews were transcribed using Clova Note and Naver’s AI transcription tool. Subsequently, the ‘Word Cloud Generator 3.7’ program was employed to extract, visualize, and analyze frequently mentioned words and key concepts from the responses. Results Semantic analysis identified 61 significant keywords and 10 subcategories, categorized into four main themes: ‘oral health challenges in the elderly,’ ‘work system of home-based dental hygienists,’ ‘needs and realities of home-based oral care,’ and ‘payment and compensation frameworks.’ Conclusions: To address the demands of a super-aging society, it is imperative to establish a standardized oral healthcare cost system for home-based interventions, supported by clear laws and regulations.

Objectives: This qualitative study explores the perspectives of dental hygienists and examines factors influencing payment structures in a community home-based oral health care intervention program. Methods: Focus group interviews were conducted on October 26, 2023, in a quiet study room over 120 minutes. Intervention providers who participated in the older adults medical care integration support program were included in this study. Their ages ranged from 25 to 57 years, with experience in home-based oral healthcare spanning from 1.5 to 5 years. Voice recordings of the interviews were transcribed using Clova Note and Naver’s AI transcription tool. Subsequently, the ‘Word Cloud Generator 3.7’ program was employed to extract, visualize, and analyze frequently mentioned words and key concepts from the responses. Results Semantic analysis identified 61 significant keywords and 10 subcategories, categorized into four main themes: ‘oral health challenges in the elderly,’ ‘work system of home-based dental hygienists,’ ‘needs and realities of home-based oral care,’ and ‘payment and compensation frameworks.’ Conclusions: To address the demands of a super-aging society, it is imperative to establish a standardized oral healthcare cost system for home-based interventions, supported by clear laws and regulations.

Objectives: This qualitative study explores the perspectives of dental hygienists and examines factors influencing payment structures in a community home-based oral health care intervention program. Methods: Focus group interviews were conducted on October 26, 2023, in a quiet study room over 120 minutes. Intervention providers who participated in the older adults medical care integration support program were included in this study. Their ages ranged from 25 to 57 years, with experience in home-based oral healthcare spanning from 1.5 to 5 years. Voice recordings of the interviews were transcribed using Clova Note and Naver’s AI transcription tool. Subsequently, the ‘Word Cloud Generator 3.7’ program was employed to extract, visualize, and analyze frequently mentioned words and key concepts from the responses. Results Semantic analysis identified 61 significant keywords and 10 subcategories, categorized into four main themes: ‘oral health challenges in the elderly,’ ‘work system of home-based dental hygienists,’ ‘needs and realities of home-based oral care,’ and ‘payment and compensation frameworks.’ Conclusions: To address the demands of a super-aging society, it is imperative to establish a standardized oral healthcare cost system for home-based interventions, supported by clear laws and regulations.

Objectives: This qualitative study explores the perspectives of dental hygienists and examines factors influencing payment structures in a community home-based oral health care intervention program. Methods: Focus group interviews were conducted on October 26, 2023, in a quiet study room over 120 minutes. Intervention providers who participated in the older adults medical care integration support program were included in this study. Their ages ranged from 25 to 57 years, with experience in home-based oral healthcare spanning from 1.5 to 5 years. Voice recordings of the interviews were transcribed using Clova Note and Naver’s AI transcription tool. Subsequently, the ‘Word Cloud Generator 3.7’ program was employed to extract, visualize, and analyze frequently mentioned words and key concepts from the responses. Results Semantic analysis identified 61 significant keywords and 10 subcategories, categorized into four main themes: ‘oral health challenges in the elderly,’ ‘work system of home-based dental hygienists,’ ‘needs and realities of home-based oral care,’ and ‘payment and compensation frameworks.’ Conclusions: To address the demands of a super-aging society, it is imperative to establish a standardized oral healthcare cost system for home-based interventions, supported by clear laws and regulations.

The prevalence of thyroid cancer in pregnant women is unknown; however, given that thyroid cancer commonly develops in women, especially young women of childbearing age, new cases are often diagnosed during pregnancy. This recommendation summarizes the follow-up and treatment when thyroid cancer is diagnosed during pregnancy and when a woman with thyroid cancer becomes pregnant. If diagnosed in the first trimester, surgery should be postponed until after delivery, and the patient should be monitored with ultrasound. If follow-up before 24–26 weeks of gestation shows that thyroid cancer has progressed, surgery should be considered. If it has not progressed at 24–26 weeks of gestation or if papillary thyroid cancer is diagnosed after 20 weeks of pregnancy, surgery should be considered after delivery.

Differentiated thyroid cancer demonstrates a wide range of clinical presentations, from very indolent cases to those with an aggressive prognosis. Therefore, diagnosing and treating each cancer appropriately based on its risk status is important. The Korean Thyroid Association (KTA) has provided and amended the clinical guidelines for thyroid cancer management since 2007. The main changes in this revised 2024 guideline include 1) individualization of surgical extent according to pathological tests and clinical findings, 2) application of active surveillance in low-risk papillary thyroid microcarcinoma, 3) indications for minimally invasive surgery, 4) adoption of World Health Organization pathological diagnostic criteria and definition of terminology in Korean, 5) update on literature evidence of recurrence risk for initial risk stratification, 6) addition of the role of molecular testing, 7) addition of definition of initial risk stratification and targeting thyroid stimulating hormone (TSH) concentrations according to ongoing risk stratification (ORS), 8) addition of treatment of perioperative hypoparathyroidism, 9) update on systemic chemotherapy, and 10) addition of treatment for pediatric patients with thyroid cancer.

Purpose: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. Materials and Methods: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. Results: Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020). Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.

Purpose: To compare serum selenium levels in Graves patients and non-Graves control participants and to evaluate associations between serum selenium levels and clinical features of Graves orbitopathy (GO). Methods: We conducted a single-center, retrospective case-control study among 33 patients with Graves disease without GO (GD), 31 patients with diagnosed GO, and 27 unaffected healthy participants enrolled between 2013 and 2020 at Severance Hospital. We compared serum selenium concentrations between the GD, GO, and healthy control groups, and analyzed associations between serum selenium and GO patients’ clinical activity scores, severity (assessed through modified NOSPECS scores), and other clinical features using multivariate linear regression analysis. Results: Mean serum selenium levels were 109.30 ± 16.39, 111.39 ± 14.04, and 126.09 ± 21.09 ng/mL in GO patients, GD patients, and healthy control participants, respectively. Mean serum selenium levels in Graves patients with and without orbitopathy were significantly lower than those in the healthy control group (p < 0.05), and mean selenium levels were slightly lower in GO than those in GD patients (p = 0.594). Serum selenium levels were significantly lower in GO patients with eyelid retraction than in patients without retraction (p = 0.038). However, serum selenium levels were not associated with clinical activity scores and modified NOSPECS scores (p = 0.241 and 0.801, respectively). Conclusions Serum selenium levels were significantly lower in Graves patients with or without GO, compared to non-Graves control participants. Selenium levels were not associated with clinical activity scores or NOSPECS scores, though we observed an association with eyelid retraction.

Atypical chronic myeloid leukemia (aCML), BCR-ABL1-negative is a rare myeloid neoplasm, especially in pediatric patients. The mutations identified in aCML have overlapped with those of other myeloid neoplasms. In recent studies, ruxolitinib, a Janus kinase (JAK) inhibitor, was found efficient in some patients of aCML with CSF3R mutation. Here, we report a pediatric case of aCML with CSF3Rmutation who did not respond to ruxoritinib, but was successfully rescued with hematopoietic stem cell transplantation (SCT). A stuporous 13-year-old boy was transferred with leukocytosis.Computed tomography showed an acute lobar intracranial hemorrhage in the left frontal lobe. The bone marrow aspirate demonstrated significant granulocytic proliferations with predominant dysplasia. Hydroxyurea and imatinib were initially administered to reduce leukocytosis. After BCR-ABL1 was found to be negative, imatinib was discontinued. After the identification of CSF3R mutation by customized targeted DNA sequencing (NGeneBio, Seoul, South Korea), ruxolitinib was added. He seemed to have hematologic and clinical responses on 2 months of ruxolitinib treatment, but the blast counts in the bone marrow increased. He underwent a full-matched unrelated peripheral blood SCT successfully 3 months after his diagnosis and has currently been disease-free 8 months since the transplantation. In conclusion, ruxolitinib for aCML with CSF3R mutation might not always induce a significant response but could be used as bridge to hematopoietic SCT.

To investigate signals of adverse drug reactions of finasteride by using the Korea Adverse Events Reporting System (KAERS) database. This pharmacovigilance was based on the database of the drug-related adverse reactions reported spontaneously to the KAERS from 2013 to 2017. This study was conducted by disproportionality analysis. Data mining analysis was performed to detect signals of finasteride. The signal was defined by three criteria as proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). The signals of finasteride were compared with those of the other drugs; dutasteride (similar mechanism of action), minoxidil (different mechanism but similar indications for alopecia), silodosin (different mechanism but similar indications for BPH). It was examined whether the detected signals exist in drug labels in Korea. The total number of adverse eventdrug pairs was reported 2,665,429 from 2013 to 2017, of which 1,426 were associated with finasteride. The number of investigated signals of finasteride was 42. The signals that did not include in the drug label were 29 signals, including mouth dry, hypotension, dysuria etc. The signal of finasteride was similar to that of dutasteride and silodosin but was different to that of minoxidil. Early detection of signals through pharmacovigilance is important to patient safety. We investigated 29 signals of finasteride that do not exist in drug labels in Korea. Further pharmacoepidemiological studies should be needed to evaluate the signal causality with finasteride.