Purpose: This study compared the outcomes of haploidentical-related donor (HRD) and umbilical cord blood (UCB) hematopoietic stem cell transplantation (HSCT) in pediatric patients with hematologic malignancies. Methods: Data on patients who underwent HRD HSCT with post-transplant cyclophosphamide (n = 41) and UCB HSCT (n = 24) after targeted busulfan-based myeloablative conditioning with intensive pharmacokinetic monitoring between 2009 and 2018 were retrospectively analyzed. Results: The median follow-up durations in the HRD and UCB groups were 7.0 and 10.9 years, respectively. The cumu‑ lative incidence of acute graft-versus-host disease (GVHD) grades II–IV and moderate-to-severe chronic GVHD did not differ significantly between the groups. However, the HRD group demonstrated significantly lower rates of acute GVHD grades III–IV (4.9% vs. 29.2%, p = 0.009) and non-relapse mortality (2.6% vs. 34.2%, p < 0.001) but a higher relapse incidence (32.1% vs. 8.8%, p = 0.004) than the UCB group. The 5-year event-free and overall survival rates were 65.8% and 54.2% (p = 0.204) and 78.0% and 65.7% (p = 0.142) for the HRD and UCB groups, respectively. Multivariate analysis identified disease status as a significant risk factor for overall survival (hazard ratio, 3.24; p = 0.016). Additionally, UCB HSCT exhibited a trend toward worse event-free survival compared to HRD HSCT (hazard ratio, 2.63; p = 0.05). Conclusions These findings indicate that HRD HSCT with post-transplant cyclophosphamide provides promising outcomes compared to UCB HSCT in pediatric patients, with a trend toward improved survival over a long-term follow-up period exceeding a median of 7 years. Thus, HRD HSCT may be a valuable option for pediatric patients with‑ out human leukocyte antigen-matched donors.

Purpose: This study compared the outcomes of haploidentical-related donor (HRD) and umbilical cord blood (UCB) hematopoietic stem cell transplantation (HSCT) in pediatric patients with hematologic malignancies. Methods: Data on patients who underwent HRD HSCT with post-transplant cyclophosphamide (n = 41) and UCB HSCT (n = 24) after targeted busulfan-based myeloablative conditioning with intensive pharmacokinetic monitoring between 2009 and 2018 were retrospectively analyzed. Results: The median follow-up durations in the HRD and UCB groups were 7.0 and 10.9 years, respectively. The cumu‑ lative incidence of acute graft-versus-host disease (GVHD) grades II–IV and moderate-to-severe chronic GVHD did not differ significantly between the groups. However, the HRD group demonstrated significantly lower rates of acute GVHD grades III–IV (4.9% vs. 29.2%, p = 0.009) and non-relapse mortality (2.6% vs. 34.2%, p < 0.001) but a higher relapse incidence (32.1% vs. 8.8%, p = 0.004) than the UCB group. The 5-year event-free and overall survival rates were 65.8% and 54.2% (p = 0.204) and 78.0% and 65.7% (p = 0.142) for the HRD and UCB groups, respectively. Multivariate analysis identified disease status as a significant risk factor for overall survival (hazard ratio, 3.24; p = 0.016). Additionally, UCB HSCT exhibited a trend toward worse event-free survival compared to HRD HSCT (hazard ratio, 2.63; p = 0.05). Conclusions These findings indicate that HRD HSCT with post-transplant cyclophosphamide provides promising outcomes compared to UCB HSCT in pediatric patients, with a trend toward improved survival over a long-term follow-up period exceeding a median of 7 years. Thus, HRD HSCT may be a valuable option for pediatric patients with‑ out human leukocyte antigen-matched donors.

Purpose: This study compared the outcomes of haploidentical-related donor (HRD) and umbilical cord blood (UCB) hematopoietic stem cell transplantation (HSCT) in pediatric patients with hematologic malignancies. Methods: Data on patients who underwent HRD HSCT with post-transplant cyclophosphamide (n = 41) and UCB HSCT (n = 24) after targeted busulfan-based myeloablative conditioning with intensive pharmacokinetic monitoring between 2009 and 2018 were retrospectively analyzed. Results: The median follow-up durations in the HRD and UCB groups were 7.0 and 10.9 years, respectively. The cumu‑ lative incidence of acute graft-versus-host disease (GVHD) grades II–IV and moderate-to-severe chronic GVHD did not differ significantly between the groups. However, the HRD group demonstrated significantly lower rates of acute GVHD grades III–IV (4.9% vs. 29.2%, p = 0.009) and non-relapse mortality (2.6% vs. 34.2%, p < 0.001) but a higher relapse incidence (32.1% vs. 8.8%, p = 0.004) than the UCB group. The 5-year event-free and overall survival rates were 65.8% and 54.2% (p = 0.204) and 78.0% and 65.7% (p = 0.142) for the HRD and UCB groups, respectively. Multivariate analysis identified disease status as a significant risk factor for overall survival (hazard ratio, 3.24; p = 0.016). Additionally, UCB HSCT exhibited a trend toward worse event-free survival compared to HRD HSCT (hazard ratio, 2.63; p = 0.05). Conclusions These findings indicate that HRD HSCT with post-transplant cyclophosphamide provides promising outcomes compared to UCB HSCT in pediatric patients, with a trend toward improved survival over a long-term follow-up period exceeding a median of 7 years. Thus, HRD HSCT may be a valuable option for pediatric patients with‑ out human leukocyte antigen-matched donors.

Objectives: This study aims to evaluate the efficacy of single-tuft toothbrushes in removing dental plaque, particularly in areas that are difficult to reach using conventional toothbrushes. The study also explores the current level of awareness and usage of these brushes, and it identifies gaps in research and education regarding their application. Methods: A scoping review was conducted using the framework proposed by Arksey and O’Malley and guidelines by Peters et al. Databases including PubMed, Scopus, and Korean academic repositories were searched using keywords like “single-tuft toothbrush” and “end-tuft toothbrush.” A total of 403 articles were initially identified, with 9 studies meeting the inclusion criteria. These studies included 8 randomized controlled trials and 1 in-vitro experiment, focusing on the effectiveness of single-tuft toothbrushes in various contexts. Results: Single-tuft toothbrushes demonstrated superior plaque removal in challenging areas, such as interproximal surfaces of molars, lingual surfaces, and around orthodontic appliances. In combination with conventional toothbrushes, they showed significantly better results compared to conventional tools alone. However, they did not consistently outperform other interdental cleaning devices like floss or interdental brushes across all metrics. User satisfaction with single-tuft toothbrushes was high, especially among orthodontic patients, although their usage rate was significantly lower due to limited awareness and accessibility. Conclusions Single-tuft toothbrushes are highly effective as adjuncts to conventional oral hygiene tools, particularly in managing hard-to-reach areas. However, their overall efficacy in replacing other oral hygiene tools is limited. To maximize their potential, increased public awareness, improved accessibility, and targeted education programs are needed. Further research should explore their role in specific patient populations, such as those with orthodontic appliances or implant restorations.

Objectives: This study aims to evaluate the efficacy of single-tuft toothbrushes in removing dental plaque, particularly in areas that are difficult to reach using conventional toothbrushes. The study also explores the current level of awareness and usage of these brushes, and it identifies gaps in research and education regarding their application. Methods: A scoping review was conducted using the framework proposed by Arksey and O’Malley and guidelines by Peters et al. Databases including PubMed, Scopus, and Korean academic repositories were searched using keywords like “single-tuft toothbrush” and “end-tuft toothbrush.” A total of 403 articles were initially identified, with 9 studies meeting the inclusion criteria. These studies included 8 randomized controlled trials and 1 in-vitro experiment, focusing on the effectiveness of single-tuft toothbrushes in various contexts. Results: Single-tuft toothbrushes demonstrated superior plaque removal in challenging areas, such as interproximal surfaces of molars, lingual surfaces, and around orthodontic appliances. In combination with conventional toothbrushes, they showed significantly better results compared to conventional tools alone. However, they did not consistently outperform other interdental cleaning devices like floss or interdental brushes across all metrics. User satisfaction with single-tuft toothbrushes was high, especially among orthodontic patients, although their usage rate was significantly lower due to limited awareness and accessibility. Conclusions Single-tuft toothbrushes are highly effective as adjuncts to conventional oral hygiene tools, particularly in managing hard-to-reach areas. However, their overall efficacy in replacing other oral hygiene tools is limited. To maximize their potential, increased public awareness, improved accessibility, and targeted education programs are needed. Further research should explore their role in specific patient populations, such as those with orthodontic appliances or implant restorations.

Objectives: This study aims to evaluate the efficacy of single-tuft toothbrushes in removing dental plaque, particularly in areas that are difficult to reach using conventional toothbrushes. The study also explores the current level of awareness and usage of these brushes, and it identifies gaps in research and education regarding their application. Methods: A scoping review was conducted using the framework proposed by Arksey and O’Malley and guidelines by Peters et al. Databases including PubMed, Scopus, and Korean academic repositories were searched using keywords like “single-tuft toothbrush” and “end-tuft toothbrush.” A total of 403 articles were initially identified, with 9 studies meeting the inclusion criteria. These studies included 8 randomized controlled trials and 1 in-vitro experiment, focusing on the effectiveness of single-tuft toothbrushes in various contexts. Results: Single-tuft toothbrushes demonstrated superior plaque removal in challenging areas, such as interproximal surfaces of molars, lingual surfaces, and around orthodontic appliances. In combination with conventional toothbrushes, they showed significantly better results compared to conventional tools alone. However, they did not consistently outperform other interdental cleaning devices like floss or interdental brushes across all metrics. User satisfaction with single-tuft toothbrushes was high, especially among orthodontic patients, although their usage rate was significantly lower due to limited awareness and accessibility. Conclusions Single-tuft toothbrushes are highly effective as adjuncts to conventional oral hygiene tools, particularly in managing hard-to-reach areas. However, their overall efficacy in replacing other oral hygiene tools is limited. To maximize their potential, increased public awareness, improved accessibility, and targeted education programs are needed. Further research should explore their role in specific patient populations, such as those with orthodontic appliances or implant restorations.

Objectives: This study aims to evaluate the efficacy of single-tuft toothbrushes in removing dental plaque, particularly in areas that are difficult to reach using conventional toothbrushes. The study also explores the current level of awareness and usage of these brushes, and it identifies gaps in research and education regarding their application. Methods: A scoping review was conducted using the framework proposed by Arksey and O’Malley and guidelines by Peters et al. Databases including PubMed, Scopus, and Korean academic repositories were searched using keywords like “single-tuft toothbrush” and “end-tuft toothbrush.” A total of 403 articles were initially identified, with 9 studies meeting the inclusion criteria. These studies included 8 randomized controlled trials and 1 in-vitro experiment, focusing on the effectiveness of single-tuft toothbrushes in various contexts. Results: Single-tuft toothbrushes demonstrated superior plaque removal in challenging areas, such as interproximal surfaces of molars, lingual surfaces, and around orthodontic appliances. In combination with conventional toothbrushes, they showed significantly better results compared to conventional tools alone. However, they did not consistently outperform other interdental cleaning devices like floss or interdental brushes across all metrics. User satisfaction with single-tuft toothbrushes was high, especially among orthodontic patients, although their usage rate was significantly lower due to limited awareness and accessibility. Conclusions Single-tuft toothbrushes are highly effective as adjuncts to conventional oral hygiene tools, particularly in managing hard-to-reach areas. However, their overall efficacy in replacing other oral hygiene tools is limited. To maximize their potential, increased public awareness, improved accessibility, and targeted education programs are needed. Further research should explore their role in specific patient populations, such as those with orthodontic appliances or implant restorations.

Objectives: This study addressed longstanding issues in Korea’s public health dentist system by defining and standardizing job duties. A practical job description was drafted based on job analysis results to promote work efficiency and lay the groundwork for future educational programs. Methods: The job description elements were selected and drafted based on previous studies.These drafts were revised and refined with expert panel validation. Results: The main job duties of public health dentists encompass community oral health, dental practice, public oral health research, and special oral health, tailored for institutions such as health sub-centers, health centers, health clinics, national health organizations, and correctional facilities. For community oral health at public health subcenters involves 12 key duties including projects, education, and community engagement. Public health centers/clinics focus on 16 key duties mainly around health project planning and evaluation. Dental care across both settings has 15 main duties. Public oral health research emphasizes community surveys and epidemiology. Special oral health in correctional facilities covers 11 main duties including education and external resource linking. Conclusions It concluded that for the development of public health dentists in South Korea, it is necessary to develop public health dentist education programs to promote the performance of public health dentists and to equip them with the competencies necessary to perform such duties, focusing on job descriptions organized around the characteristics of workplaces and major tasks.