Objective To analyze the secondary metabolites of Abrus cantoniensis Hance based on plant metabolomics,and the quality marker(Q-marker)of Abrus cantoniensis Hance by multivariate statistics and network pharmacology prediction.Methods The chemical constituents of 11 batches of Abrus cantoniensis Hance were analyzed by UPLC-Q-TOF-MS methods established and their common components were confirmed.At the same time,cluster analysis(HCA),principal component analysis(PCA)and partial least squares discriminant analysis(OPLS-DA)were carried out to identify the main differential components that caused the classification of the multi-batch medicinal materials of Abrus cantoniensis Hance.Then,the network of"core components-core target-core pathway"was constructed through network pharmacology to screen and predict the potential Q-marker of Abrus cantoniensis Hance,and molecular docking verification was applied to further predict the activity.Results 39 common components were identified in 11 batches of Abrus cantoniensis Hance,mainly containing triterpenoid saponins,flavonoids,alkaloids,etc.HCA and PCA analysis showed that 11 batches of Abrus cantoniensis Hance were divided into 4 categories,and OPLS-DA analysis showed that 9 chemical components played an important role in the classification.The results of network pharmacology analysis showed that the above 9 components which acted on 166 targets were active components,and 29 core targets were obtained by protein interaction(PPI)screening.Among them,four chemical components,Abrine,Hypaphorine,SoyasaponinⅠ and Arginine,were highly correlated with the core targets.Combined with the concept of Q-marker and molecular docking results,it was preliminarily predicted that Abrine and Hypaphorine would be the Q-markers of Abrus cantoniensis Hance.Conclusion The Q-marker of Abrus cantoniensis Hance can be predicted and analyzed by plant metabolomics combined with multivariate statistics and network pharmacology.This study provided data reference for the quality control and evaluation of Abrus cantoniensis Hance and research ideas for further scientific development of Abrus cantoniensis Hance.

The emergency medical rescue for nuclear accidents in nuclear submarine is a major challenge to Chinese navy. In this article, we studied the construction demands for nuclear submarine emergency medical rescue, compared the development of equipment technology and the current status of nuclear submarine emergency medical rescue training in China and other countries, analyzed the unsolved problems in China and the gap between China and the countries with more advanced development in terms of nuclear submarine emergency medical rescue, and put forward suggestions for the future construction goals and plans for the rescue system.

The emergency medical rescue for nuclear accidents in nuclear submarine is a major challenge to Chinese navy. In this article, we studied the construction demands for nuclear submarine emergency medical rescue, compared the development of equipment technology and the current status of nuclear submarine emergency medical rescue training in China and other countries, analyzed the unsolved problems in China and the gap between China and the countries with more advanced development in terms of nuclear submarine emergency medical rescue, and put forward suggestions for the future construction goals and plans for the rescue system.

Objective To investigate clinical features,induction factors and causes of upper digestive tract homorrhage in the shipboard personnel,so as to provide evidence for its prevention and treatment.Methods Clinical data of 336 cases with upper digestive tract homorrhage among the shipboard personnel were analyzed retrospectively.At the same time,971 cases of upper digestive tract homorrhage that occurred in the non-shipboad personnel with the same age catogery were selected as control.Results The shipboard personnel with upper digestive tract homorrhage were mostly under the age of 30,while the non-shipboard personnel who had the same problem were older than 30.Main induction factors of upper digestive tract hemonrhage among the shipboard personnel were:motion sickness (accounting for 58.6％),next excessive fatigue (accounting for 10.2％);then mental stress (accounting for 8.6％),and finally alcoholism (accounting for 7.7％).Research findings revealed that the disorder was not directy related to the application of nonsteroidal antiinflammtory drugs (NSAIDs).On the other hand,main induction factors of upper digestive tract hemorrhage in the non-shipboard personnel were:alcoholism and the application of NSAIDs,and the disorder was also closely related with excessive fatigue,mental stress and excessive eating.The main causes of upper digestive tract hemorrhage among the shipboard personnel were peptic ulcer,gastric mucosal erosion and cardia laceration,while the main reason for upper digestive tract homorrhage among the non-shipboard personnel was also peptic ulcer.In addition,gastro-esophageal varices,gastric mucosal erosion and gastric cancer were also common causes for the disorder (accouting for 41.8％).Conclusions The main induction factor of upper digestive tract homorrhage among the shipboard personnel was motion sickness and the main cause of the disease was peptic ulcer.For this reason,measures should be taken to guard against motion sickness,e.g.strengthening anti-seasickness exercise,and administering medication and acupuncture when motion sickness occurred.The prevention and treatment of motion sickness would help to reduce the occurrence of peptic ulcer.For the patients with known peptic ulcer,the administration of mucosal protective agent and a proton pump inhibitor could achieve satisfactory results.

Objective To investigate clinical features,induction factors and causes of upper digestive tract homorrhage in the shipboard personnel,so as to provide evidence for its prevention and treatment.Methods Clinical data of 336 cases with upper digestive tract homorrhage among the shipboard personnel were analyzed retrospectively.At the same time,971 cases of upper digestive tract homorrhage that occurred in the non-shipboad personnel with the same age catogery were selected as control.Results The shipboard personnel with upper digestive tract homorrhage were mostly under the age of 30,while the non-shipboard personnel who had the same problem were older than 30.Main induction factors of upper digestive tract hemonrhage among the shipboard personnel were:motion sickness (accounting for 58.6％),next excessive fatigue (accounting for 10.2％);then mental stress (accounting for 8.6％),and finally alcoholism (accounting for 7.7％).Research findings revealed that the disorder was not directy related to the application of nonsteroidal antiinflammtory drugs (NSAIDs).On the other hand,main induction factors of upper digestive tract hemorrhage in the non-shipboard personnel were:alcoholism and the application of NSAIDs,and the disorder was also closely related with excessive fatigue,mental stress and excessive eating.The main causes of upper digestive tract hemorrhage among the shipboard personnel were peptic ulcer,gastric mucosal erosion and cardia laceration,while the main reason for upper digestive tract homorrhage among the non-shipboard personnel was also peptic ulcer.In addition,gastro-esophageal varices,gastric mucosal erosion and gastric cancer were also common causes for the disorder (accouting for 41.8％).Conclusions The main induction factor of upper digestive tract homorrhage among the shipboard personnel was motion sickness and the main cause of the disease was peptic ulcer.For this reason,measures should be taken to guard against motion sickness,e.g.strengthening anti-seasickness exercise,and administering medication and acupuncture when motion sickness occurred.The prevention and treatment of motion sickness would help to reduce the occurrence of peptic ulcer.For the patients with known peptic ulcer,the administration of mucosal protective agent and a proton pump inhibitor could achieve satisfactory results.