Objective:To verify the reliability and validity of the Chinese Version of Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN-C) in patients with major depressive disorder(MDD).Methods:A total of 122 patients with MDD and 122 controls were recruited and measured with the BRIAN-C, 16-Item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16), 7-Item Generalized Anxiety Disorder Scale(GAD-7) and 6-Item Short Form Health Survey(SF-6). The index D and correlation analysis were conducted to evaluate the discrimination and homogeneity of the items, respectively. The Cronbach′s α coefficient, Spearman-Brown coefficient, intraclass correlation coefficient ( ICC) and retest correlation coefficient were conducted to evaluate the reliability.Confirmatory factor analysis, correlation analysis and the receiver operating characteristic (ROC) curve were conducted to evaluate the construct validity, criterion validity and prediction validity, respectively. Results:The item distinction and homogeneity analysis showed significant differences ( P<0.05). The Cronbach′s α coefficient and the Spearman-Brown coefficient were 0.911 and 0.807, while the ICC and the correlation coefficient r of test-retest reliability were 0.639 (95% confidence interval( CI):0.375-0.729) and 0.43 ( P=0.001), respectively. Confirmatory factor analysis showed that the fit indexes χ 2/dF=1.937, goodness-of-fit index(GFI)=0.822, comparative fit index (CFI)=0.877, Tucker-lewis index (TLI)=0.855, and root mean square error of approximation (RMSEA)=0.088. The score of BRIAN-C was significantly correlated with that of QIDS-SR16, GAD-7 or SF-6 ( r=0.74, 0.46, -0.69, all P<0.05).The ROC curve suggested that the area under curve (AUC) was 0.939 (95% CI: 0.909-0.970, P<0.05) for distinguishing MDD patients from controls. The optimal cut-off was 29, with 0.861 sensitivity and 0.926 specificity. Conclusions:The BRIAN-C scale has good reliability and validity, which is supposed to be used in Chinese cultural background to evaluate the biorhythms in patients with MDD.

Objective:To verify the reliability and validity of the Chinese Version of Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN-C) in patients with major depressive disorder(MDD).Methods:A total of 122 patients with MDD and 122 controls were recruited and measured with the BRIAN-C, 16-Item Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16), 7-Item Generalized Anxiety Disorder Scale(GAD-7) and 6-Item Short Form Health Survey(SF-6). The index D and correlation analysis were conducted to evaluate the discrimination and homogeneity of the items, respectively. The Cronbach′s α coefficient, Spearman-Brown coefficient, intraclass correlation coefficient ( ICC) and retest correlation coefficient were conducted to evaluate the reliability.Confirmatory factor analysis, correlation analysis and the receiver operating characteristic (ROC) curve were conducted to evaluate the construct validity, criterion validity and prediction validity, respectively. Results:The item distinction and homogeneity analysis showed significant differences ( P<0.05). The Cronbach′s α coefficient and the Spearman-Brown coefficient were 0.911 and 0.807, while the ICC and the correlation coefficient r of test-retest reliability were 0.639 (95% confidence interval( CI):0.375-0.729) and 0.43 ( P=0.001), respectively. Confirmatory factor analysis showed that the fit indexes χ 2/dF=1.937, goodness-of-fit index(GFI)=0.822, comparative fit index (CFI)=0.877, Tucker-lewis index (TLI)=0.855, and root mean square error of approximation (RMSEA)=0.088. The score of BRIAN-C was significantly correlated with that of QIDS-SR16, GAD-7 or SF-6 ( r=0.74, 0.46, -0.69, all P<0.05).The ROC curve suggested that the area under curve (AUC) was 0.939 (95% CI: 0.909-0.970, P<0.05) for distinguishing MDD patients from controls. The optimal cut-off was 29, with 0.861 sensitivity and 0.926 specificity. Conclusions:The BRIAN-C scale has good reliability and validity, which is supposed to be used in Chinese cultural background to evaluate the biorhythms in patients with MDD.

Anorexia nervosa (AN) is a type of eating disorder characterized by severe malnutrition and abnormally low body weights, resulting from patients′ intentionally strict restrictions on eating. Patients with AN often have body image disturbances and are comorbid with psychiatric symptoms, such as obsessive-compulsive symptoms, depression, anxiety, and so forth. These patients may suffer from severe malnutrition, amenorrhea, and even death since they refuse to eat. As a mental disorder with a high mortality rate, there is still no specific medicine to treat AN. This case is a female patient with AN treated with bilateral anterior capsulotomy (BACA) combined with deep brain stimulation (DBS). The treatment efficacy was evident. Before the operation, her body mass index (BMI) was only 12.22 kg/m 2. She had repeated binge-eating-emetic behaviors, severe obsessive-compulsive symptoms, anxiety and depression, suicide attempt, severe malnutrition, amenorrhea, recurrent infections, and so forth. At the 3-month follow-up after the operation, the patient was emotionally stable and had a BMI of 19.40 kg/m 2. The reducing rates of the total scores of the Hamilton Anxiety Scale (HAMA), the 24-item Hamilton Depression Scale (HAMD 24), and the Yale-Brown Obsessive-Compulsive Scale (Y-BROW) were 64%, 64%, and 52%, respectively. This study found that BACA combined with DBS surgery can rapidly and effectively improve the prognosis of patients with the binge-eating/purging subtype of AN.

Anorexia nervosa (AN) is a type of eating disorder characterized by severe malnutrition and abnormally low body weights, resulting from patients′ intentionally strict restrictions on eating. Patients with AN often have body image disturbances and are comorbid with psychiatric symptoms, such as obsessive-compulsive symptoms, depression, anxiety, and so forth. These patients may suffer from severe malnutrition, amenorrhea, and even death since they refuse to eat. As a mental disorder with a high mortality rate, there is still no specific medicine to treat AN. This case is a female patient with AN treated with bilateral anterior capsulotomy (BACA) combined with deep brain stimulation (DBS). The treatment efficacy was evident. Before the operation, her body mass index (BMI) was only 12.22 kg/m 2. She had repeated binge-eating-emetic behaviors, severe obsessive-compulsive symptoms, anxiety and depression, suicide attempt, severe malnutrition, amenorrhea, recurrent infections, and so forth. At the 3-month follow-up after the operation, the patient was emotionally stable and had a BMI of 19.40 kg/m 2. The reducing rates of the total scores of the Hamilton Anxiety Scale (HAMA), the 24-item Hamilton Depression Scale (HAMD 24), and the Yale-Brown Obsessive-Compulsive Scale (Y-BROW) were 64%, 64%, and 52%, respectively. This study found that BACA combined with DBS surgery can rapidly and effectively improve the prognosis of patients with the binge-eating/purging subtype of AN.