Objective:To discuss the efficacy of dredging pulmonary collaterals treatment（Suzi Jiangqi decoction plus Scolopendra and Scorpio）on the level of IL-1β in induced sputum in patients with refractory asthma. Methods:A total of 60 patients with refractory asthma，admitted to the two affiliated hospitals of Shanghai University of Tradition Chinese Medicine，were randomly assigned to control group and treatment group. Both groups were given aerosol inhalation of salmeterol，fluticasone，and tiotropium bromide. Additionally，the control group was given Suzi Jiangqi decoction，while the treatment group was given Suzi Jiangqi decoction plus Scolopendra and Scorpio. Both groups were treated for 12 weeks. Asthma control test（ACT）scores，IL-1β levels in induced sputum，and safety indicators such as complete blood count，and lung，liver，and renal functions were compared between the two groups. Results:After treatment，the ACT score，the forced expiratory volume in the first second（FEV 1.0），and the ratio of FEV 1.0 to the forced vital capacity（FEV 1.0/FVC）all increased，while the IL-1β levels decreased in both two groups. And the treatment group had significantly better improvements in the above-mentioned items than the control group，all with statistically significant differences（ P<0.05 or P<0.01）. Before and after treatment，there was no obvious change in the level of eosinophil in peripheral blood in either group. After treatment，all the safety indicators were within normal ranges in both groups. Conclusion:Suzi Jiangqi decoction plus Scolopendra and Scorpio can effectively control the severity of asthma and improve the lung function in patients with refractory asthma by reducing the level of IL-1β in induced sputum，the mechanism of action may be related to the inhibition of cell pyroptosis.

Objective:To discuss the efficacy of dredging pulmonary collaterals treatment（Suzi Jiangqi decoction plus Scolopendra and Scorpio）on the level of IL-1β in induced sputum in patients with refractory asthma. Methods:A total of 60 patients with refractory asthma，admitted to the two affiliated hospitals of Shanghai University of Tradition Chinese Medicine，were randomly assigned to control group and treatment group. Both groups were given aerosol inhalation of salmeterol，fluticasone，and tiotropium bromide. Additionally，the control group was given Suzi Jiangqi decoction，while the treatment group was given Suzi Jiangqi decoction plus Scolopendra and Scorpio. Both groups were treated for 12 weeks. Asthma control test（ACT）scores，IL-1β levels in induced sputum，and safety indicators such as complete blood count，and lung，liver，and renal functions were compared between the two groups. Results:After treatment，the ACT score，the forced expiratory volume in the first second（FEV 1.0），and the ratio of FEV 1.0 to the forced vital capacity（FEV 1.0/FVC）all increased，while the IL-1β levels decreased in both two groups. And the treatment group had significantly better improvements in the above-mentioned items than the control group，all with statistically significant differences（ P<0.05 or P<0.01）. Before and after treatment，there was no obvious change in the level of eosinophil in peripheral blood in either group. After treatment，all the safety indicators were within normal ranges in both groups. Conclusion:Suzi Jiangqi decoction plus Scolopendra and Scorpio can effectively control the severity of asthma and improve the lung function in patients with refractory asthma by reducing the level of IL-1β in induced sputum，the mechanism of action may be related to the inhibition of cell pyroptosis.

Objective:To evaluate the clinical efficacy of kidney-invigorating and asthma-relieving granules in treating kidney deficiency type of bronchial asthma patients in persistent.Methods:A total of 100 patients with bronchial asthma admitted to Shanghai Municipal Hospital of TCM from March 2020 to August 2020 were selected as the research subjects. The patients were divided into control group and treatment group by random and double blind method, 50 in each group. Both groups were treated by routine basic treatment. The control group was treated with Kidney-invigorating and asthma-relieving Placebo, while the observation group was treated with kidney-invigorating and asthma-relieving granules. All the treatment lasted for 6 weeks. The TCM syndromes scores, Asthma Control Test (ACT) scores, Peak expiratory flow/predicted value (PEF%) and eosinophil in peripheral blood before and after treatment were observed.Results:A total of 91 patients completed the clinical study. There were 45 patients in the control group and 46 in the treatment group. The total effective rate in the treatment group was 93.5% (43/46), while that in the control group was 77.8% (35/45), and the difference was statistically significant ( χ2=4.579, P=0.032). After the treatment, the scores of integral efficacy on syndromes in Chinese medicine, ACT and PEF% in the treatment group were significantly higher than those in the control group ( t values were 2.802, 3.420 and 8.938, respectively, all Ps<0.01). The eosinophil in peripheral blood of patients in the treatment group was significantly lower than that of the control group ( t=3.481, P=0.001). Conclusion:On the basis of conventional treatment of western medicine, kidney-invigorating and asthma-relieving granules can relieve the clinical symptoms of asthma, improve the control level of asthma, enhance the level of PEF, reduce airway inflammation.