Objective:To investigate the awareness of diabetes knowledge among the health examination population and its influencing factors.Methods:A cross-sectional study. From september to november 2022, the subjects of six health examination centers located in six different cities (Beijing, Shanghai, Tianjin, Chongqing, Xiamen, Hangzhou) in China were investigated in the form of questionnaires to investigate the awareness of diabetes core information and the level of trust to different information sources of diabetes knowledge. According to the questionnaire results, the subjects were divided into a high awareness group of diabetes core information and a low awareness group. Logistic regression was used to analyze the influencing factors of diabetes core information awareness; the t-test was used to compare the trust degree of the two groups to different information sources. Results:A total of 9 315 people were included in the six centers, including 4 932 men (52.90%) with an average age of (39.36±12.64) years and 4 383 women (47.10%) with a mean age of (37.47±11.85) years. Only 36% of the people had high awareness of diabetes core information; variables such as gender, age, education level, physical examination frequency in the past three years, package price of this physical examination, self-evaluation of diabetes knowledge, diabetes status, and city of residence were variables that affect the level of awareness of core information related to diabetes (all P<0.05). Compared with the low awareness group of diabetes core information, the high awareness group trusted professional medical staff ( t=-9.597, P<0.05) and community health promotion more ( t=-5.014, P<0.05), but did not trust the emerging popular science propaganda means, such as WeChat official accounts/WeChat groups/QQ groups, Internet web page, Tiktok/Kwai and other short video APPs. Conclusion:The awareness rate of diabetes knowledge among the health examination population is low, and it is affected by many factors; Health education on diabetes knowledge should be carried out for people undergoing physical examination.

Objective:To explore the relationship between the changes of serum components in breast cancer after neoadjuvant chemotherapy and the efficacy of chemotherapy based on Raman spectroscopy.Methods:Raman spectra of serum samples from 110 breast cancer patients who received neoadjuvant chemotherapy and 15 healthy subjects admitted to the Department of Breast and Thyroid Surgery of the Affiliated Tumor Hospital of Xinjiang Medical University from Feb. 2013 to Jan. 2020 were detected, and PCA-LDA method was combined to predict the efficacy of neoadjuvant chemotherapy.Results:Raman spectra of breast cancer patients after neoadjuvant chemotherapy were similar to those of normal breast, with carotenoid peaks (1513 cm -1, 1518 cm -1) . Raman spectra combined with PCA-LDA showed high sensitivity and specificity (80.0%, 71.4%) in evaluating the efficacy of neoadjuvant chemotherapy for breast cancer. Conclusion:Raman spectroscopy combined with multivariate data analysis can be used as a new method to evaluate the efficacy of neoadjuvant chemotherapy for breast cancer and a new strategy to guide subsequent treatment regiments.

Objective:To analyze the safety and efficacy of endoscopic balloon dilatation (EBD) in the treatment of duodenal Crohn′s disease (CD) -associated strictures.Methods:Clinical data of 49 patients with duodenal CD-associated strictures undergoing EBD in Jinling Hospital from January 2011 to December 2019 were collected. The clinical characters, treatment plan and prognosis were analyzed.Results:There were 39 male patients and 10 female patients. The age of onset was 23 (18, 27.5) years old and the duration was 4 (1.75, 7) years. Most strictures (83.67%, 41/49) located in duodenum bulb, and the endoscopic features included mucosal hyperaemia, edema, ulcer and cobblestone-like changes. Forty-nine patients underwent 144 EBD procedures with an average of 2.94 EBD per patient. The balloon diamater of the first EBD were 1.5 cm in 28 patients (57.14%) , 1.8 cm in 12 (24.49%) , 1.2 cm in 7 (14.29%) and 1.35 cm in 2 (4.08%) . The duodenal perforation occurred in 1 patient. The technical success rate was 99.31% (143/144) . After the median follow-up period of 211 (105, 334.5) days, the treatment success rates were 100% (49/49) , 75.51% (37/49) and 42.86% (21/49) in 1 to 3 months, 3 to 6 months and 6 to 12 months after EBD respectively. Nine patients who had recurrence of strictures received surgery to remove the strictures in duodenum.Conclusion:EBD is a safe and effective treatment for duodenal CD-associated strictures.

Objective:To analyze the safety and efficacy of endoscopic balloon dilatation (EBD) in the treatment of duodenal Crohn′s disease (CD) -associated strictures.Methods:Clinical data of 49 patients with duodenal CD-associated strictures undergoing EBD in Jinling Hospital from January 2011 to December 2019 were collected. The clinical characters, treatment plan and prognosis were analyzed.Results:There were 39 male patients and 10 female patients. The age of onset was 23 (18, 27.5) years old and the duration was 4 (1.75, 7) years. Most strictures (83.67%, 41/49) located in duodenum bulb, and the endoscopic features included mucosal hyperaemia, edema, ulcer and cobblestone-like changes. Forty-nine patients underwent 144 EBD procedures with an average of 2.94 EBD per patient. The balloon diamater of the first EBD were 1.5 cm in 28 patients (57.14%) , 1.8 cm in 12 (24.49%) , 1.2 cm in 7 (14.29%) and 1.35 cm in 2 (4.08%) . The duodenal perforation occurred in 1 patient. The technical success rate was 99.31% (143/144) . After the median follow-up period of 211 (105, 334.5) days, the treatment success rates were 100% (49/49) , 75.51% (37/49) and 42.86% (21/49) in 1 to 3 months, 3 to 6 months and 6 to 12 months after EBD respectively. Nine patients who had recurrence of strictures received surgery to remove the strictures in duodenum.Conclusion:EBD is a safe and effective treatment for duodenal CD-associated strictures.

Objective To analyze the correlation between thrombelastography (TEG) and conventional coagulation indexes in breast cancer patients, and to compare the differences between the two methods in the detection of coagulation function in breast cancer patients.Methods Retrospectively analyzed the clinical data of180patients with breast cancer who were performed TEG, coagulation and blood test in the same day in our hospital from November 2016to May 2017.Linear correlation and regression analysis were performed among the parameters.The differences of positive rates of TEG parameters and conventional coagulation indexes were compared.Results The R value of TEG parameters of breast cancer patients was positively correlated with K and APTT, and negatively correlated withα-Angle, MA, CI, DD, FDPs.K was positively correlated with APTT and TT, and negatively correlated withα-Angle, MA, FIB, DD, FDPs and PLT.α-Angle was positively correlated with MA, CI, FIB, DD, FDPs and PLT.MA was positively correlated with CI, FIB, DD, FDPs and PLT.CI was positively correlated with FIB, DD, FDPs and PLT.α-Angle, MA and CI were all negatively correlated with APTT and TT, the difference were statistically significant (P＜0.05).A linear regression equation of TEG parameters and coagulation indexes was obtained.There was no significant difference between TEG detection positive rate and conventional coagulation test (P＞0.05).Conclusion There are significant correlation between the TEG parameters and routine coagulation or platelet, and the results are consistent.

Objective To analyze the correlation between thrombelastography(TEG)and coagulation, platelet count(PLT)in patients with malignant tumor.Methods Retrospectively analyzed the clinical data of 241 cases with tumor who were performed TEG,coagulation and blood test in the same day in Chongqing Cancer Institute from November 2016 to March 2017.Linear correlation and regression were carried out to an-alyze relationship among the parameters.The number of patients with positive blood clotting,PLT and TEG parameters were counted,and the χ2test was used to compare the difference between them.Using Mann-Whit-ney U test to compare the differences between multiple parameters of liver cancer,breast cancer,and pancreatic cancer.Results The R value of TEG parameters in patients with malignant tumor was positively correlated with APTT,negatively correlated with TT,DD and FDPs.K was positively correlated with APTT and TT, and negatively correlated with FIB and PLT.The relationship between α and FIB,PLT were positive,between APTT and TT were negative.MA was positively correlated with FIB and PLT,negatively correlated with TT, CI was positively correlated with FIB and PLT,and negatively correlated with APTT(P<0.05).The correla-tion between FIB,PLT and MA was the highest.And the linear regression equation of TEG parameters and coagulation indexes was obtained.The positive rate of TEG was lower than that of coagulation(P<0.05). Same certain differences of TEG and coagulation parameters were existed in liver cancer,breast cancer and pancreatic cancer patients.Conclusion TEG is significantly associated with PLT and conventional coagulation test,and the results of TEG and conventional coagulation test are consistent to a certain degree,but the overall agreement is generally not interchangeable.TEG might be play a complementary role with coagulation tests and platelet counts.And the TEG of different cancer types is not exactly the same as the coagulation parameters.

In recent years, the pollution problem of particulate matter, especially PM2.5, is becoming more and more serious, which has attracted many people's attention from all over the world. In this paper, a Kalman prediction model combined with cubic spline interpolation is proposed, which is applied to predict the concentration of PM2.5 in the micro-regional environment of campus, and to realize interpolation simulation diagram of concentration of PM2.5 and simulate the spatial distribution of PM2.5. The experiment data are based on the environmental information monitoring system which has been set up by our laboratory. And the predicted and actual values of PM2.5 concentration data have been checked by the way of Wilcoxon signed-rank test. We find that the value of bilateral progressive significance probability was 0.527, which is much greater than the significant level = 0.05. The mean absolute error (MEA) of Kalman prediction model was 1.8 μg/m , the average relative error (MER) was 6%, and the correlation coefficient was 0.87. Thus, the Kalman prediction model has a better effect on the prediction of concentration of PM2.5 than those of the back propagation (BP) prediction and support vector machine (SVM) prediction. In addition, with the combination of Kalman prediction model and the spline interpolation method, the spatial distribution and local pollution characteristics of PM2.5 can be simulated.

Objective To explore the intervention effect of group intervention model on care-givers of patients with serious brain injury (SBI), so as to provide evidence for improving mental status and coping styles of their care-givers. Methods From May to December 2016, by convenience sampling, 56 care-givers of SBI patients admitted to Neurosurgery Department in Xiangya Hospital Central South University were selected and were divided according to random number table into control group and intervention group, each with 28 cases. Two objects in the control group quitted before the study was over and another two were out of contact after discharge from the hospital. The other objects in the control group (n=24) received routine reply and guidance for their medical questions, while besides that, objects in the intervention group (n=28) received group intervention, including disease knowledge explaining and communications. Anxiety level and coping styles of care-givers in the two groups were compared at admission, before discharge and 2 weeks after leaving the hospital. Statistical analysis was done by repeated measurement analysis of variance. Results Concerning comparison of anxiety scores of care-givers from the two groups at different time points, time effect (F=107.92, P< 0.001) and interaction effect (F=5.92, P=0.01) were statistically significant, while intervention effect (F=0.94, P=0.35) was not; comparisons between the two groups of positive coping (Fintergroup=17.51, P<0.001;Ftime=78.40, P<0.001; Finteraction=5.37, P=0.01) and negative coping (Fintergroup=6.02, P=0.03; Ftime=143.44, P<0.001; Finteraction=8.55, P< 0.001) were significant. Conclusions Along with status stabilization of the SBI patients, anxiety level of their care-givers decreases. Group intervention model can improve the care-givers' positive coping and reduce their negative coping.

Objective To investigate the association of thyroid carcinoma and urine iodine level in Urumqi region,intent to provide the evidence of individual iodine supplement of this region.Methods In this case-control study,there were 100 patients with thyroid carcinoma and 300 patients with normal thyroid function as the control group in Xinjiang Tumor Hospital between February 2012 and December 2012 as the case group.All the cases were detected for urine iodine concentration by arsenic-cerium catalytic spectrophotometry.Results The mean level of urinary iodine in the case group (272.69 μg/L) was higher than that in the control group (161.40 μg/L) (P ＜ 0.05).The level of iodine was excessive (urinary iodine ＞ 300 μg/L) in 34 ％ (34/100) patients in the case group and 10 ％ (30/300) patients in control group (P ＜ 0.05).Conclusion The average urinary iodine content of the thyroid carcinoma in Urmuqi region are generally higher than that of the healthy control group,which indicates that the iodine nutritional status in patients with thyroid carcinoma are better than that in the general population.The relationship between thyroid carcinoma and excessive iodine intake should be necessary for further study.

Objective To observe the effect of swallowing training exercise for promoting rehabilitation of swallowing dysfunction after skull base tumor surgery. Methods We averagedly divided 86 patients with swallowing dysfunction into experimental group and control randomly, and the patinets of control group received routine treatment and care, the patients of experimental group not only on the basis of routine treatment and but also received a self-designed swallowing training exercise. Results The effective rate of swallowing function rehabilitation was 100. 0% in the experimental group while it was 65. 1% in the control group (U=360. 5,P<0. 01). The length of hospitalization in the experimental group was lower than that of the control group. Conclusions Swallowing training exercise can promote functional recovery, shorten hospital stay and improve the quality of life of patients.