Objective:To analyze the safety and efficacy of endoscopic balloon dilatation (EBD) in the treatment of duodenal Crohn′s disease (CD) -associated strictures.Methods:Clinical data of 49 patients with duodenal CD-associated strictures undergoing EBD in Jinling Hospital from January 2011 to December 2019 were collected. The clinical characters, treatment plan and prognosis were analyzed.Results:There were 39 male patients and 10 female patients. The age of onset was 23 (18, 27.5) years old and the duration was 4 (1.75, 7) years. Most strictures (83.67%, 41/49) located in duodenum bulb, and the endoscopic features included mucosal hyperaemia, edema, ulcer and cobblestone-like changes. Forty-nine patients underwent 144 EBD procedures with an average of 2.94 EBD per patient. The balloon diamater of the first EBD were 1.5 cm in 28 patients (57.14%) , 1.8 cm in 12 (24.49%) , 1.2 cm in 7 (14.29%) and 1.35 cm in 2 (4.08%) . The duodenal perforation occurred in 1 patient. The technical success rate was 99.31% (143/144) . After the median follow-up period of 211 (105, 334.5) days, the treatment success rates were 100% (49/49) , 75.51% (37/49) and 42.86% (21/49) in 1 to 3 months, 3 to 6 months and 6 to 12 months after EBD respectively. Nine patients who had recurrence of strictures received surgery to remove the strictures in duodenum.Conclusion:EBD is a safe and effective treatment for duodenal CD-associated strictures.

Objective:To analyze the safety and efficacy of endoscopic balloon dilatation (EBD) in the treatment of duodenal Crohn′s disease (CD) -associated strictures.Methods:Clinical data of 49 patients with duodenal CD-associated strictures undergoing EBD in Jinling Hospital from January 2011 to December 2019 were collected. The clinical characters, treatment plan and prognosis were analyzed.Results:There were 39 male patients and 10 female patients. The age of onset was 23 (18, 27.5) years old and the duration was 4 (1.75, 7) years. Most strictures (83.67%, 41/49) located in duodenum bulb, and the endoscopic features included mucosal hyperaemia, edema, ulcer and cobblestone-like changes. Forty-nine patients underwent 144 EBD procedures with an average of 2.94 EBD per patient. The balloon diamater of the first EBD were 1.5 cm in 28 patients (57.14%) , 1.8 cm in 12 (24.49%) , 1.2 cm in 7 (14.29%) and 1.35 cm in 2 (4.08%) . The duodenal perforation occurred in 1 patient. The technical success rate was 99.31% (143/144) . After the median follow-up period of 211 (105, 334.5) days, the treatment success rates were 100% (49/49) , 75.51% (37/49) and 42.86% (21/49) in 1 to 3 months, 3 to 6 months and 6 to 12 months after EBD respectively. Nine patients who had recurrence of strictures received surgery to remove the strictures in duodenum.Conclusion:EBD is a safe and effective treatment for duodenal CD-associated strictures.