Iron is an essential trace element for brain development and cognitive function maintenance. Iron homeostasis disruption in the body, whether due to iron overload or deficiency, may lead to a series of adverse consequences to the brain. Vascular cognitive impairment is a neurodegenerative disease characterized by cognitive impairment such as mental decline and weak thinking, which seriously endangers people's health. At present, the relationship between iron metabolism and vascular cognitive impairment is receiving more and more attention. This paper summarizes the progress of iron metabolism and its role in vascular cognitive impairment, in order to provide new ideas and methods for prevention and treatment of vascular cognitive impairment.

The diagnosis and treatment rates of hepatitis B virus (HBV) infection in China in 2020 were 22.1% and 15.0%, respectively, according to the Polaris Observatory HBV Collaborators report. This is still far below the World Health Organization's 2030 hepatitis B elimination target (90% and 80%, respectively, for the diagnosis and treatment rates). Although China has promulgated and implemented a series of policies to eliminate the hepatitis B virus, there are still many HBV infected patients who need to be detected and treated. It has been contoversial whether HBeAg-positive chronic HBV infected-patients with high viral load and normal alanine aminotransferase (ALT), also known as the "immune-tolerant phase," should receive anti-HBV therapy. Hepatologists should pay attention to the patient population known as "immune tolerant," as well as the continuous accumulation of evidence-based medical evidence for early antiviral therapy response. The current focus is on discussing the pros and cons of receiving and recommending anti-HBV therapy at this time for the management of these patients.

Objective:To investigate the use of contraceptives among postpartum women in the urban areas of Shanghai and to understand women's demands and utilization of contraceptive service.Methods:A cross-sectional survey was conducted using questionnaires in postpartum women in the clinics for 42-day postpartum follow-up and child health care in 4 districts in Shanghai (including Changning District, Jingan District, Putuo District and Yangpu District) from August 2019 to December 2019. Data were analyzed using frequency description and logistic regression.Results:In total, 1170 postpartum women were enrolled. Among them, 420 women resumed sexual intercourse at an average length of (3.6±1.5) months postpartum and the proportions of consistent contraceptive use were 69.4%(43/62), 77.2% (186/241), 79.2% (57/72) and 71.1% (32/45), at periods of 1 to 3 months, 4 to 6 months, 7 to 9 months and 10 to 12 months after delivery respectively. Planned pregnancy, willingness to reproduce, and postpartum contraceptive guidance were associated with contraceptive behavior. Condom was the main approach used by postpartum women, while long-acting reversible contraceptive method was seldom used. The proportion of receiving guidance on contraception during postpartum home visits and 42-day postpartum follow-up were 43.3% (395/913) and 34.6% (369/1067) respectively. Totally, 37.6% (420/1117) of the total considered that the best time for contraceptive health education was at the 42-day postpartum follow-up, while 30.5% (341/1117) of them preferred health education during pregnancy.Conclusion:About one-quarter of postpartum women do not adhere to contraception in the urban areas of Shanghai. The proportion of using long-acting reversible contraceptive methods, such as intrauterine devices and subcutaneous, remains low. It is necessary to strengthen postpartum contraceptive services, to provide professional training, and strengthen guidance on the proper selection and use of contraceptive methods, especially for long-acting contraceptive methods. Meanwhile, the guidance for contraception should be advanced during pregnancy.

Objective:To investigate the use of contraceptives among postpartum women in the urban areas of Shanghai and to understand women's demands and utilization of contraceptive service.Methods:A cross-sectional survey was conducted using questionnaires in postpartum women in the clinics for 42-day postpartum follow-up and child health care in 4 districts in Shanghai (including Changning District, Jingan District, Putuo District and Yangpu District) from August 2019 to December 2019. Data were analyzed using frequency description and logistic regression.Results:In total, 1170 postpartum women were enrolled. Among them, 420 women resumed sexual intercourse at an average length of (3.6±1.5) months postpartum and the proportions of consistent contraceptive use were 69.4%(43/62), 77.2% (186/241), 79.2% (57/72) and 71.1% (32/45), at periods of 1 to 3 months, 4 to 6 months, 7 to 9 months and 10 to 12 months after delivery respectively. Planned pregnancy, willingness to reproduce, and postpartum contraceptive guidance were associated with contraceptive behavior. Condom was the main approach used by postpartum women, while long-acting reversible contraceptive method was seldom used. The proportion of receiving guidance on contraception during postpartum home visits and 42-day postpartum follow-up were 43.3% (395/913) and 34.6% (369/1067) respectively. Totally, 37.6% (420/1117) of the total considered that the best time for contraceptive health education was at the 42-day postpartum follow-up, while 30.5% (341/1117) of them preferred health education during pregnancy.Conclusion:About one-quarter of postpartum women do not adhere to contraception in the urban areas of Shanghai. The proportion of using long-acting reversible contraceptive methods, such as intrauterine devices and subcutaneous, remains low. It is necessary to strengthen postpartum contraceptive services, to provide professional training, and strengthen guidance on the proper selection and use of contraceptive methods, especially for long-acting contraceptive methods. Meanwhile, the guidance for contraception should be advanced during pregnancy.

Objective:To assess the health status and health service utilization of children born to syphilis infected mothers during pregnancy, in order to prevent mother-to-child transmission of syphilis to the newborns.Methods:Women with maternal syphilis were studied by trained researchers via phone calls, in Shanghai during 2014-2015. Data related to demographics, status of infection and health care, utilization by both mothers and their children were collected through specifically designed questionnaires. Non-parametric tests including chi-square were used to assess the health status and health service utilization of children born to mothers with different demographic and socioeconomic characteristics.Results:A total of 495 children born to mothers with maternal syphilis were recruited from 1 000 syphilis infected parturient women. A total of 61 out of the 495 children were diagnosed as having congenital syphilis (57 children were diagnosed at birth and another 4 were diagnosed during the follow-up period). Children born to women who received syphilis treatment during pregnancy were at lower risk on congenital syphilis ( χ2=7.214, P=0.027). 37.8 % of the children were reported to have had different illnesses in the past three months, mainly involving upper respiratory infections (32.3 %) or diarrhea (3.6 %). Children diagnosed with congenital syphilis showed a higher prevalence of different kinds of diseases, compared to those without congenital syphilis (47.5 % vs. 36.6 %). 81.6 % of the children had received regular child health care services. Subjects with the following factors as: being immigrant, with lower education, unemployed, unmarried and multipara, were related to the less use of regular child healthcare services. Only 39.7 % of the parents would inform the care-takers about the risk of congenital syphilis infection of their own children at the child health care centers. Mothers with residency of Shanghai, having higher education level and employed, were less willing to inform doctors about the risk of congenital syphilis infection of their children. Conclusions:Loss to follow-up among children born to syphilis infected pregnant women remained a serious problem. Few parents would be willing to inform the healthcare takers that their children are at risk of syphilis, when receiving child health care services at the centers. It was necessary to integrate the congenital syphilis follow-up programs into the routine child care services so as to timely diagnose and treat the patients with congenital syphilis.

Depressive disorder is a prevalent psychiatric disorder with complicated pathological mechanism.It has been proved that aseptic inflammation of the central nervous system (CNS) plays an important role in the pathogenesis of depressive disorder. High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein widely presented in eukaryotic nuclei that can induce the central inflammatory response when released into the extracellular space, which in turn participates in the onset of depressive disorder. Therefore, this paper reviewed the researches of HMGB1 in depressive disorder, in order to provide reference for further research.

Depressive disorder is a prevalent psychiatric disorder with complicated pathological mechanism.It has been proved that aseptic inflammation of the central nervous system (CNS) plays an important role in the pathogenesis of depressive disorder. High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein widely presented in eukaryotic nuclei that can induce the central inflammatory response when released into the extracellular space, which in turn participates in the onset of depressive disorder. Therefore, this paper reviewed the researches of HMGB1 in depressive disorder, in order to provide reference for further research.

Objective: To investigate the role of gut microbiota in the amelioration of liver fibrosis induced by CCl4 in mice by 3-methyladenine (3-MA). Methods: Fifteen mice were randomly divided into normal control group, liver fibrosis group and 3-MA treatment group. The liver fibrosis model was established by injecting CCl4, and the mice in the 3-MA treatment group were injected 3-MA additionally from the third week onwards. After 8 weeks, all of the mice were sacrificed and their blood, liver tissue and fecal samples were collected to analyze serum ALT, AST, GGT levels, liver histopathology and gut microbiota. Results: Compared with the liver fibrosis group, serum ALT and AST levels in 3-MA treatment group decreased obviously ([68.6±4.2] U/L vs [111.0±7.8] U/L, [179.0±12.9] U/L vs [253.2±26.7] U/L, P＜0.01), and the degree of hepatic histopathological changes was reduced. The intestinal flora in three groups were distinguished by principal coordinate analysis (PCoA) and non-metric multi-dimensional scaling (NMDS) analysis. Compared with the normal control group, there were decreased Alpha diversity of intestinal community, reduced significantly abundance of Lachnospiraceae, and increased obviously abundance of Actinobacteria and Desulfovibrionacea in the liver fibrosis group (P＜0.05). Compared with the liver fibrosis group, there were increased Alpha diversity of intestinal community, increased significantly abundance of Lachnospiraceae and Blautia, and reduced abundance of Bifidobacteriaceae in the 3-MA treatment group (P＜0.05). In addition, the abundance of Lactobacillaceae in the 3-MA treatment group was significantly higher than that in the normal control group (P＜0.05). Conclusion 3-MA improves the liver fibrosis of mice induced by CCl4, and gut microbiota may play an active role in this process.

Objective To understand the cigarette consumption of Guangzhou residents and its influencing factors. Method The stratified random sampling was adopted and the selected families were visited by trained investigators with questionnaire from April to August in 2004. Results 27718 residents over 15 years old were investigated. The smoking rate was 22.7%, and 46.2% for male and 2.0% for female. The currently smoking rate was 19.9% (male 40.5% and female 1.6%). The currently smokers lighted up their first cigarette when they were 20 years old in median and their consumption were averagely 14.3 sticks everyday. 13.1% smokers tried to quit smoking. 9.4% people who once gave up cigarette picked it up again. The Logistic Stepwise Regression analysis showed sex (OR=0.022, 95%CI: 0.019~0.026), education (OR=0.697, 95%CI: 0.659~0.737), family income(OR=0.975, 95%CI: 0.955~0.995)and alcohol drinking(OR=2.687, 95%CI: 2.467~2.927)were found to be the influencing factors for individual smoking. Conclusion The resident smoking rate was lower in Guangzhou than that in Guangdong province or in China but it was still very higher. The most smokers were male and little of them quitted smoking. The tobacco control should be enhanced.