Autoimmune encephalitis is a type of encephalitis mediated by autoimmune mechanisms, with more than half of the patients requiring intensive care due to consciousness disorder, severe movement disorders, autonomic dysfunction, and status epilepticus. In the early stages, the symptoms of autoimmune encephalitis are varied, including cognitive decline, memory impairments, behavioral changes, movement disorders, and seizures. Without timely and appropriate treatment, it may progress into severe autoimmune encephalitis (SAE) due to challenges in early recognition. Early diagnosis and prompt immunotherapy are crucial for determining the prognosis. The current research evidence and related guidelines, discussing aspects such as symptom management, complication management, and immunotherapy strategies for SAE patients were summarized in this article, with the aim of providing effective references for clinical practice.

Autoimmune encephalitis is a type of encephalitis mediated by autoimmune mechanisms, with more than half of the patients requiring intensive care due to consciousness disorder, severe movement disorders, autonomic dysfunction, and status epilepticus. In the early stages, the symptoms of autoimmune encephalitis are varied, including cognitive decline, memory impairments, behavioral changes, movement disorders, and seizures. Without timely and appropriate treatment, it may progress into severe autoimmune encephalitis (SAE) due to challenges in early recognition. Early diagnosis and prompt immunotherapy are crucial for determining the prognosis. The current research evidence and related guidelines, discussing aspects such as symptom management, complication management, and immunotherapy strategies for SAE patients were summarized in this article, with the aim of providing effective references for clinical practice.

Cytoskeleton-associated protein 2(CKAP2)gene is located on human chromosome 13q14.3 and encodes cytoskeleton associated protein 2,which is involved in regulating the separation of mitotic chromosomes.CKAP2 has been confirmed in multiple studies to be an oncogenic gene that can regulate JAK2/STAT3,FAK-ERK2,and NF-κB signaling pathway affects the biological behaviors of tumor cells such as proliferation,apoptosis,and inva-sion,alters the tumor microenvironment,and regulates tumor immunity.CKAP2 is also closely related to the forma-tion of spindle bodies during mitosis,and dysregulation of CKAP2 can lead to incorrect chromosome separation,promoting tumor development.In addition,CKAP2 is closely related to chemotherapy resistance in tumors,and the underlying mechanisms are not yet clear.CKAP2 may become a novel tumor marker and effective therapeutic target,playing an important role in the diagnosis and treatment of tumors.