[Purpose]To analyze the causes of death and potential life loss of malignant tumors in Sichuan Province from 2017 to 2022.[Methods]Data were collected from the death information registration and management system of China Disease Prevention and Control Information System,and national cause of death monitoring sites in Sichuan Province from 2017 to 2022.SAS 9.4 and Joinpoint 4.9.1.0 software were used to calculate crude cancer mortality rate,age-standardized mortality rate by Chinese standerd population(ASMRC),annual percentage change and potential years of life lost(PYLL)and potential years of life lost rate(PYLLR).[Results]From 2017 to 2022,the crude cancer mortality rate in Sichuan Province was 169.32/105,and the ASMRC was 111.26/105.The cancer mortality rate in the general population and that stratified by sex showed an increasing trend(all P＜0.05).The top 5 causes of cancer death were lung cancer,liver cancer,esophageal cancer,gastric cancer and colorectum cancer.The mortality rates of lung cancer,colorectum can-cer,female breast cancer,pancreatic cancer,lip,oral and pharyngeal malignancies all increased(all P＜0.05).From 2017 to 2022,the PYLL caused by malignant tumors in Sichuan Province was 1 520 175.00 person-year,the PYLLR was 13.98‰.[Conclusion]In Sichuan Province,the mortali-ty rate of malignant tumors is on the rise.Lung cancer and gastrointestinal cancers are the main malignancies causing life loss.Early diagnosis and treatment of key cancers should be strengthened to reduce cancer mortality.

Objective:To identify the risk factors of venous thromboembolism (VTE) in postoperative renal transplantation recipients by Meta-analysis, and to provide evidence-based reference for clinical staff to develop early VTE prevention strategies.Methods:PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, VIP database, Wanfang database and Chinese Biomedical Literature Database were searched to collect the studies on the risk factors of postoperative VTE in kidney transplant recipients. The search period was from the establishment of the database to March 10, 2024. After literature screening, data extraction and quality evaluation were conducted independently by two researchers, Meta-analysis was performed using RevMan 5.3 software.Results:A total of 15 literatures with 20 influencing factors were included. Meta-analysis showed that age ( MD = 6.36, 95% CI 2.56-10.17, P<0.05), body mass index ( MD = 1.83, 95% CI 0.15-3.50, P<0.05), VTE history ( OR = 2.04, 95% CI 1.08-3.86, P<0.05), blood transfusion history ( OR = 3.77, 95% CI 2.43-5.83, P<0.05), glomerular filtration rate ( MD = -5.54, 95% CI -9.93 - -0.91, P<0.05), donor age ( MD = 3.18, 95% CI 1.10-5.25, P<0.05), combination of malignant tumor ( OR = 2.87, 95% CI 1.45-5.68, P<0.05), end-stage renal disease as polycystic kidney disease ( OR = 1.76, 95% CI 1.39-2.22, P<0.05), and interstitial nephritis ( OR = 1.60, 95% CI 1.06-2.40, P<0.05) were the influencing factors for postoperative VTE in renal transplant recipients. Conclusions:Clinical medical staff should actively identify high-risk groups for VTE after kidney transplantation by considering the 8 influencing factors determined by this study, and take targeted measures early to reduce the risk of postoperative VTE.

Objective:To identify the risk factors of venous thromboembolism (VTE) in postoperative renal transplantation recipients by Meta-analysis, and to provide evidence-based reference for clinical staff to develop early VTE prevention strategies.Methods:PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, VIP database, Wanfang database and Chinese Biomedical Literature Database were searched to collect the studies on the risk factors of postoperative VTE in kidney transplant recipients. The search period was from the establishment of the database to March 10, 2024. After literature screening, data extraction and quality evaluation were conducted independently by two researchers, Meta-analysis was performed using RevMan 5.3 software.Results:A total of 15 literatures with 20 influencing factors were included. Meta-analysis showed that age ( MD = 6.36, 95% CI 2.56-10.17, P<0.05), body mass index ( MD = 1.83, 95% CI 0.15-3.50, P<0.05), VTE history ( OR = 2.04, 95% CI 1.08-3.86, P<0.05), blood transfusion history ( OR = 3.77, 95% CI 2.43-5.83, P<0.05), glomerular filtration rate ( MD = -5.54, 95% CI -9.93 - -0.91, P<0.05), donor age ( MD = 3.18, 95% CI 1.10-5.25, P<0.05), combination of malignant tumor ( OR = 2.87, 95% CI 1.45-5.68, P<0.05), end-stage renal disease as polycystic kidney disease ( OR = 1.76, 95% CI 1.39-2.22, P<0.05), and interstitial nephritis ( OR = 1.60, 95% CI 1.06-2.40, P<0.05) were the influencing factors for postoperative VTE in renal transplant recipients. Conclusions:Clinical medical staff should actively identify high-risk groups for VTE after kidney transplantation by considering the 8 influencing factors determined by this study, and take targeted measures early to reduce the risk of postoperative VTE.

[Purpose]To analyze the causes of death and potential life loss of malignant tumors in Sichuan Province from 2017 to 2022.[Methods]Data were collected from the death information registration and management system of China Disease Prevention and Control Information System,and national cause of death monitoring sites in Sichuan Province from 2017 to 2022.SAS 9.4 and Joinpoint 4.9.1.0 software were used to calculate crude cancer mortality rate,age-standardized mortality rate by Chinese standerd population(ASMRC),annual percentage change and potential years of life lost(PYLL)and potential years of life lost rate(PYLLR).[Results]From 2017 to 2022,the crude cancer mortality rate in Sichuan Province was 169.32/105,and the ASMRC was 111.26/105.The cancer mortality rate in the general population and that stratified by sex showed an increasing trend(all P＜0.05).The top 5 causes of cancer death were lung cancer,liver cancer,esophageal cancer,gastric cancer and colorectum cancer.The mortality rates of lung cancer,colorectum can-cer,female breast cancer,pancreatic cancer,lip,oral and pharyngeal malignancies all increased(all P＜0.05).From 2017 to 2022,the PYLL caused by malignant tumors in Sichuan Province was 1 520 175.00 person-year,the PYLLR was 13.98‰.[Conclusion]In Sichuan Province,the mortali-ty rate of malignant tumors is on the rise.Lung cancer and gastrointestinal cancers are the main malignancies causing life loss.Early diagnosis and treatment of key cancers should be strengthened to reduce cancer mortality.

The condylar movement trajectories in healthy people usually have relatively consistent characteristics,while the change of the trajectory of the temporomandibular condyle often indicates the occurrence of various oral diseases.An in-depth understanding of the condylar movement can help physicians diagnose and evaluate the efficacy of oral diseases.This article reviews the development of con-dylar motion tracing technique,and introduces the research progress and clinical application status of condylar motion tracing analysis in various oral diseases.At the same time,the limitations of the current condylar motion tracing technique and the prospect of future clinical application are proposed.

In recent years, it has been found that mammalian target of rapamycin (mTOR) is related to the pathogenesis of inflammatory bowel disease (IBD). Rapamycin plays an important role in inflammatory response, cell proliferation, metabolism, apoptosis and autophagy by inhibiting mTOR. To better understand the application prospects of rapamycin in IBD, this paper reviews the mechanism of action of rapamycin, clinic application and the current application status of rapamycin in IBD.

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with unknown pathogenesis, and some IBD patients do not respond well to conventional medications. Currently, mammalian target of rapamycin (mTOR) can affect intestinal autophagy and inflammation progress through various mechanisms such as PI3K/AKT/mTOR, TLR4/MAPK/mTOR and AMPK/mTOR. By this way, mTOR can play a significant role in its pathogenesis. Targeting mTOR signaling pathway provides new therapeutic options for IBD. In this article, the mechanisms of mTOR signaling pathway in IBD and the targeted treatment of mTOR signaling pathway for IBD were summarized.

In recent years, it has been found that mammalian target of rapamycin (mTOR) is related to the pathogenesis of inflammatory bowel disease (IBD). Rapamycin plays an important role in inflammatory response, cell proliferation, metabolism, apoptosis and autophagy by inhibiting mTOR. To better understand the application prospects of rapamycin in IBD, this paper reviews the mechanism of action of rapamycin, clinic application and the current application status of rapamycin in IBD.

Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with unknown pathogenesis, and some IBD patients do not respond well to conventional medications. Currently, mammalian target of rapamycin (mTOR) can affect intestinal autophagy and inflammation progress through various mechanisms such as PI3K/AKT/mTOR, TLR4/MAPK/mTOR and AMPK/mTOR. By this way, mTOR can play a significant role in its pathogenesis. Targeting mTOR signaling pathway provides new therapeutic options for IBD. In this article, the mechanisms of mTOR signaling pathway in IBD and the targeted treatment of mTOR signaling pathway for IBD were summarized.

Objectives:This study aims to evaluate the reliability and validity of the Chinese version of the 4-item Negative Symptom Assessment (NSA-4) in patients with schizophrenia.Methods:A total of 172 patients with schizophrenia were recruited and assessed with the Chinese version of NSA-4, the Scale for Assessment of Negative Symptoms (SANS), PANSS, and the Calgary Depression Scale for Schizophrenia (CDSS). Cronbach′s α was computed to evaluate internal consistency. Intraclass correlation coefficients (ICCs) were computed to evaluate the inter-rater reliability and Spearman's correlation analysis was used to evaluate the test-retest reliability. Spearman′s correlation analyses were conducted between NSA-4 and SANS, PANSS, and CDSS to evaluate concurrent validity, convergent validity, and discriminant validity, respectively.Results:Cronbach′s α for the Chinese version of the NSA-4 was 0.788. ICCs were 0.661-0.958 and test-retest reliability was 0.860. The Chinese version of the NSA-4 showed satisfactory concurrent validity considering its high correlation with SANS ( r=0.801), excellent convergent validity considering its high correlation with PANSS total score and negative symptom subscale score ( r=0.528-0.834), and good discriminant validity considering its weak correlation with scores of the positive symptom subscale and general psychopathology subscale of PANSS and CDSS ( r=0.069-0.358). Conclusion:The Chinese version of the NSA-4 has good psychometric properties. It is useful for rapid assessment of negative symptoms in patients with schizophrenia.