Objective To investigate the cytokine levels in patients in acute stage of intracranial ar-terial occlusion and its correlation with infarct volume and functional prognosis.Methods A total of 168 patients with large artery intracranial occlusion admitted in Department of Neurosurgery of Huaihe Hospital from January 2021 to December 2023 were enrolled and then divided into good prognosis group(54 cases)and poor prognosis group(114 cases)according to their functional prognosis within 90 d after onset.The cytokine levels in acute stage and infarct volume were col-lected,and their correlation with infarct volume and functional prognosis was analyzed.Results The poor prognosis group had significantly larger proportion of hypertension,longer time from onset to admission,higher NIHSS score at admission,larger infarct core volume,and elevated lev-els of IL-1,IL-6,IL-8,TNF-α,MMP-9,reactive oxygen species(ROS)and VEGF than the good prognosis group(P＜0.05,P＜0.01).Pearson correlation analysis showed that infarct core volume was positively correlated with the levels of IL-1,IL-6,IL-8,TNF-α,MMP-9,ROS and VEGF(P＜0.01).Multivariate logistic regression analysis indicated that after removing confounding var-iables(time from onset to admission,NIHSS at admission and infarct core volume),IL-1(OR=1.723,95％CI:1.333-2.227,P=0.000),IL-6(OR=1.475,95％CI:1.190-1.830,P=0.000),TNF-α(OR=1.392,95％CI:1.167-1.661,P=0.000),MMP-9(OR=1.062,95％CI:1.031-1.094,P=0.000)and ROS(OR=1.020,95％CI:1.007-1.034,P=0.003)were still independent influencing factors for poor functional prognosis in the patients.Conclusion Infarct core volume is positively correlated with IL-1,IL-6,IL-8,TNF-α,MMP-9,ROS and VEGF.In the acute stage,cy-tokines IL-1,IL-6,TNF-α,MMP-9 and ROS are independent influencing factors for poor function-al prognosis in patients with intracranial arterial occlusion.

Objective To investigate the cytokine levels in patients in acute stage of intracranial ar-terial occlusion and its correlation with infarct volume and functional prognosis.Methods A total of 168 patients with large artery intracranial occlusion admitted in Department of Neurosurgery of Huaihe Hospital from January 2021 to December 2023 were enrolled and then divided into good prognosis group(54 cases)and poor prognosis group(114 cases)according to their functional prognosis within 90 d after onset.The cytokine levels in acute stage and infarct volume were col-lected,and their correlation with infarct volume and functional prognosis was analyzed.Results The poor prognosis group had significantly larger proportion of hypertension,longer time from onset to admission,higher NIHSS score at admission,larger infarct core volume,and elevated lev-els of IL-1,IL-6,IL-8,TNF-α,MMP-9,reactive oxygen species(ROS)and VEGF than the good prognosis group(P＜0.05,P＜0.01).Pearson correlation analysis showed that infarct core volume was positively correlated with the levels of IL-1,IL-6,IL-8,TNF-α,MMP-9,ROS and VEGF(P＜0.01).Multivariate logistic regression analysis indicated that after removing confounding var-iables(time from onset to admission,NIHSS at admission and infarct core volume),IL-1(OR=1.723,95％CI:1.333-2.227,P=0.000),IL-6(OR=1.475,95％CI:1.190-1.830,P=0.000),TNF-α(OR=1.392,95％CI:1.167-1.661,P=0.000),MMP-9(OR=1.062,95％CI:1.031-1.094,P=0.000)and ROS(OR=1.020,95％CI:1.007-1.034,P=0.003)were still independent influencing factors for poor functional prognosis in the patients.Conclusion Infarct core volume is positively correlated with IL-1,IL-6,IL-8,TNF-α,MMP-9,ROS and VEGF.In the acute stage,cy-tokines IL-1,IL-6,TNF-α,MMP-9 and ROS are independent influencing factors for poor function-al prognosis in patients with intracranial arterial occlusion.