Objective:To investigate the relationship between different types of tea intake and COVID-19 infection.Methods:Data were retrieved from a genome-wide association study(GWAS),involving 447 485,and 64 949 people for single nucleotide polymorphisms(SNPs).Two-sample Mendelian randomization(MR)analysis was used to investigate the relationship of different types of tea intake with four subgroups of COVID-19 infected population,including COVID-19 infected population versus general population,COVID-19 hospitalized population versus general population,COVID-19 hospitalized population versus non-hospitalized population,and very severe respiratory confirmed population versus general population.Inverse-variance weighted(IVW)method was used as the main method of causal analysis.MR Egger intercept was used for pleiotropy test,and Cochran's Q-statistic was used for heterogeneity test.Results:Compared to the general population,tea intake decreased the incidence of COVID-19 in the infection population(IVW method,OR=0.806,95%CI:0.651-0.999),and the hospitalized population(IVW method,OR=0.533,95%CI:0.369-0.770).Additionally,the underlying pleiotropy was not found following the MR-Egger regression intercept(MR intercept=-0.002,P=0.667),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=52.712,P=0.057).Compared to the general population,the underlying pleiotropy in the hospitalized patients was not found by MR-Egger regression intercept(MR intercept=-0.001,P=0.909),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=25.214,P=0.945).However,green tea and herbal tea had no effect on COVID-19 infection.Conclusions:Overall tea intake reduces the risk of COVID-19 infection in the general population compared to COVID-19 infected and hospitalized populations,while green tea and herbal tea have no protective effect against COVID-19 infection.

Objective:To investigate the relationship between different types of tea intake and COVID-19 infection.Methods:Data were retrieved from a genome-wide association study(GWAS),involving 447 485,and 64 949 people for single nucleotide polymorphisms(SNPs).Two-sample Mendelian randomization(MR)analysis was used to investigate the relationship of different types of tea intake with four subgroups of COVID-19 infected population,including COVID-19 infected population versus general population,COVID-19 hospitalized population versus general population,COVID-19 hospitalized population versus non-hospitalized population,and very severe respiratory confirmed population versus general population.Inverse-variance weighted(IVW)method was used as the main method of causal analysis.MR Egger intercept was used for pleiotropy test,and Cochran's Q-statistic was used for heterogeneity test.Results:Compared to the general population,tea intake decreased the incidence of COVID-19 in the infection population(IVW method,OR=0.806,95%CI:0.651-0.999),and the hospitalized population(IVW method,OR=0.533,95%CI:0.369-0.770).Additionally,the underlying pleiotropy was not found following the MR-Egger regression intercept(MR intercept=-0.002,P=0.667),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=52.712,P=0.057).Compared to the general population,the underlying pleiotropy in the hospitalized patients was not found by MR-Egger regression intercept(MR intercept=-0.001,P=0.909),and the Cochran's Q-statistic showed no heterogeneity(Q-statistic=25.214,P=0.945).However,green tea and herbal tea had no effect on COVID-19 infection.Conclusions:Overall tea intake reduces the risk of COVID-19 infection in the general population compared to COVID-19 infected and hospitalized populations,while green tea and herbal tea have no protective effect against COVID-19 infection.

Objective:To investigate the association between cardiometabolic multimorbidity(CMM)and cardiometabolic diseases(CMDs)with frailty in elderly patients suffering from chronic diseases in rural Shandong.Additionally, it seeks to analyze the role of self-efficacy in chronic disease management in mitigating the risk of frailty associated with CMM and CMDs.Methods:A multi-stage cluster random sampling method was employed to select 2, 778 elderly patients aged 60 and above with chronic diseases in rural Shandong Province.Frailty was assessed using the Frailty Phenotype(FP), while self-efficacy in chronic disease management was measured using the Self-Efficacy to Manage Chronic Disease Scale(SEMCD).For the analysis, binary logistic regression and marginal effects were utilized.Results:The prevalence of frailty among elderly patients with chronic diseases in rural Shandong was found to be 12.28%, while the prevalence of CMM was reported at 53.20%.Binary logistic regression analysis revealed that frailty was significantly associated with several factors, including age, education level, annual per capita income, employment status, and self-efficacy in managing chronic disease(all P<0.05).Notably, increases in CMM( P=0.001)and the number of CMDs( P<0.001)were linked to a heightened risk of frailty.Furthermore, marginal effects analysis indicated that individuals in the high self-efficacy group exhibited significantly lower risks of frailty associated with CMM and CMDs compared to those in the low self-efficacy group, with risk reductions of 96.9%(95% CI: -1.258--0.681, P<0.001)and 85.7%(95% CI: -1.175--0.539, P<0.001), respectively. Conclusions:Both the presence of CMM and a higher number of CMDs are linked to an increased risk of frailty.However, elevated levels of self-efficacy in chronic disease management can significantly mitigate the frailty risk associated with CMM and CMDs.It is advisable to enhance health education and self-management training, as well as to establish a comprehensive, multidisciplinary, and multidimensional health management system for the elderly.This approach aims to improve self-efficacy in chronic disease management among rural elderly populations, thereby preventing and addressing the onset of frailty.

Objective:To investigate the association between cardiometabolic multimorbidity(CMM)and cardiometabolic diseases(CMDs)with frailty in elderly patients suffering from chronic diseases in rural Shandong.Additionally, it seeks to analyze the role of self-efficacy in chronic disease management in mitigating the risk of frailty associated with CMM and CMDs.Methods:A multi-stage cluster random sampling method was employed to select 2, 778 elderly patients aged 60 and above with chronic diseases in rural Shandong Province.Frailty was assessed using the Frailty Phenotype(FP), while self-efficacy in chronic disease management was measured using the Self-Efficacy to Manage Chronic Disease Scale(SEMCD).For the analysis, binary logistic regression and marginal effects were utilized.Results:The prevalence of frailty among elderly patients with chronic diseases in rural Shandong was found to be 12.28%, while the prevalence of CMM was reported at 53.20%.Binary logistic regression analysis revealed that frailty was significantly associated with several factors, including age, education level, annual per capita income, employment status, and self-efficacy in managing chronic disease(all P<0.05).Notably, increases in CMM( P=0.001)and the number of CMDs( P<0.001)were linked to a heightened risk of frailty.Furthermore, marginal effects analysis indicated that individuals in the high self-efficacy group exhibited significantly lower risks of frailty associated with CMM and CMDs compared to those in the low self-efficacy group, with risk reductions of 96.9%(95% CI: -1.258--0.681, P<0.001)and 85.7%(95% CI: -1.175--0.539, P<0.001), respectively. Conclusions:Both the presence of CMM and a higher number of CMDs are linked to an increased risk of frailty.However, elevated levels of self-efficacy in chronic disease management can significantly mitigate the frailty risk associated with CMM and CMDs.It is advisable to enhance health education and self-management training, as well as to establish a comprehensive, multidisciplinary, and multidimensional health management system for the elderly.This approach aims to improve self-efficacy in chronic disease management among rural elderly populations, thereby preventing and addressing the onset of frailty.

The male patient of middle-age was admitted to Zhujiang Hospital, Southern Medical University on September 5, 2020, due to wear and rupture of the left foot hallux for more than 10 days, gradually developed swelling and blackening of the left foot and accompanied by drowsiness for 1day. Results from etiological examination of his wound secretions suggested the mixed infection of Wohlfahrtiimonas chitiniclastica and Enterococcus faecalis. The disease progressed rapidly and the patient still died of septic shock after anti-infective treatment. The infection of W. chitiniclastica is rare and has a great relationship with poor hygiene and chronic open wounds. It is necessary to use matrix-assisted laser desorption/ionization-time of flight mass spectrometry or 16S ribosomal RNA gene sequencing for strain identification. Moreover, it is recommended to use cephalosporins or carbapenems as first-line drugs due to the poor prognosis of patients with bloodstream infections.