With the development of assisted reproductive technology (ART), more and more infertile couples have their own children. According to incomplete statistics, as of 2010, about 5 million babies worldwide were born after treatment with ART. It is not clear whether and how ART affects the sex of offspring at birth. And with the increase of the number of ART newborns, it may have a profound impact on the demographics in the future. At present, the known factors that may affect the sex ratio of newborns with ART include parental age, type of infertility, embryo transfer stage (cleavage stage/blastocyst stage), embryo transfer type (fresh embryo/frozen embryo), etc. This paper aims to review the factors that may affect the sex ratio of newborns with ART at present.

With the development of assisted reproductive technology (ART), more and more infertile couples have their own children. According to incomplete statistics, as of 2010, about 5 million babies worldwide were born after treatment with ART. It is not clear whether and how ART affects the sex of offspring at birth. And with the increase of the number of ART newborns, it may have a profound impact on the demographics in the future. At present, the known factors that may affect the sex ratio of newborns with ART include parental age, type of infertility, embryo transfer stage (cleavage stage/blastocyst stage), embryo transfer type (fresh embryo/frozen embryo), etc. This paper aims to review the factors that may affect the sex ratio of newborns with ART at present.