Objective:To investigate the intervention effect of dance therapy on the psychological symptoms and psychological craving in methamphetamine-dependent women.Methods:A total of 60 methamphetamine de-pendents in a women's drug rehabilitation center were divided into intervention group and control group(1 person dropped out).The intervention group was trained for 8 dance movements,during which the control group did not in-tervene.The Zhang Tuoji and Chen Huichang's Temperament Scale,Symptom Self-Rating Scale(SCL-90)and Amphetamine Craving Scale(DSQ)were used to evaluate the temperament type,psychological symptoms and psy-chological craving.Results:The differences of SCL-90 depression and anxiety scores(post-intervention score-base-line score)and DSQ total scores were higher in the intervention group than in the control group(Ps＜0.05).The choleric temperament scores were negatively correlated with the differences of DSQ total scores(r=-0.45,P＜0.05),and the melancholic temperament scores were positively correlated with the differences of SCL-90 hostility dimension scores(r=0.41,P＜0.05).Conclusion:Dance therapy could improve the psychological symptoms and psychological craving of women dependent on methamphetamine,with varying effects across different temperament types.

Objective:To investigate the intervention effect of dance therapy on the psychological symptoms and psychological craving in methamphetamine-dependent women.Methods:A total of 60 methamphetamine de-pendents in a women's drug rehabilitation center were divided into intervention group and control group(1 person dropped out).The intervention group was trained for 8 dance movements,during which the control group did not in-tervene.The Zhang Tuoji and Chen Huichang's Temperament Scale,Symptom Self-Rating Scale(SCL-90)and Amphetamine Craving Scale(DSQ)were used to evaluate the temperament type,psychological symptoms and psy-chological craving.Results:The differences of SCL-90 depression and anxiety scores(post-intervention score-base-line score)and DSQ total scores were higher in the intervention group than in the control group(Ps＜0.05).The choleric temperament scores were negatively correlated with the differences of DSQ total scores(r=-0.45,P＜0.05),and the melancholic temperament scores were positively correlated with the differences of SCL-90 hostility dimension scores(r=0.41,P＜0.05).Conclusion:Dance therapy could improve the psychological symptoms and psychological craving of women dependent on methamphetamine,with varying effects across different temperament types.

Objective:To explore the factors influencing electronically-delivered cognitive behavioral therapy for insomnia (e-CBTI) selection among patients with insomnia, and to provide empirical evidence for the clinical promotion of e-CBTI.Methods:Between November 2022 and July 2023, a convenience sampling method was employed to collect samples from 38 public hospitals and their surrounding communities. A total of 756 insomnia patients aged 18-65 years were included in the study. Based on their choice to participate in e-CBTI treatment, patients were divided into two groups: 605 patients (605/756,80.0%) chose to participate in e-CBTI treatment, while 151 patients (151/756,20.0%) did not. Rater-rated structured clinical interviews were applied in the current study, assessing individual′s insomnia symptoms, mental disorders, other sleep disorders, and suicidality and self-injury. The chi-square test and logistic regression were applied in data analyses.Results:Compared to the control group, the e-CBTI group had a higher proportion of females (χ 2=4.29) and a higher educational level (χ 2=5.76), while the proportion of living in rural areas was lower (χ 2=6.87), all with P<0.05. Additionally, the e-CBTI group exhibited a higher proportion of daytime symptoms compared to the control group, including decreased attention or memory (χ 2=16.42), impaired function or performance (χ 2=6.75), mood changes (χ 2=4.71), and reduced enthusiasm, energy, or motivation (χ 2=4.77), all with P<0.05. The e-CBTI group also showed a higher tendency for delayed sleep phase (χ 2=6.61), generalized anxiety disorder (χ 2=6.22), suicidal ideation (χ 2=10.45), and non-suicidal self-injury (χ 2=5.19), all with statistically significant differences ( P<0.05). Multivariate logistic regression analysis revealed that the type of residence ( OR=0.53, 95 %CI=0.29-0.95), educational level ( OR=2.42, 95 %CI=1.34-4.37), decreased attention or memory ( OR=1.95, 95 %CI=1.11-3.42), impaired function or performance ( OR=1.80, 95 %CI=1.15-2.82), and suicidal ideation ( OR=3.12, 95 %CI=1.29-7.58) remained significant influential factors in the selection of e-CBTI. Insomnia′s nighttime symptoms, including difficulty falling asleep, difficulty maintaining sleep, and early morning awakenings, were not associated with the inclination to choose e-CBTI. Conclusions:Daytime symptoms of insomnia and suicidal ideation are significant factors that prompt insomnia patients to choose e-CBTI.

Objective:To develop the Self-Stigma Scale for Drug Addicts(SSSDA),and test its validity and reliability.Methods:On the basis of literature analysis,open questionnaire survey,semi-structured interview and ex-pert consultation,the theoretical structure of the questionnaire was developed,and 943 drug addicts were test-ed.Sample 1(n=483)was used for item analysis and exploratory factor analysis,and sample 2(n=460)was used for confirmatory factor analysis,criterion related validity and internal consistency reliability analysis.Sixty-four drug addicts were retested 4 weeks later for test-retest reliability test.The criterion related validity was tested with the Drug Stereotype Threat Scale.Results:The scale consisted of 6 dimensions and 31 items,including self-negative cognition,stereotype identity,confidentiality,social avoidance,stigma experience,and stigma experience in the process of detoxification(factor loadings were from 0.41 to 0.81),which explained 64.09％of the total vari-ance.The 6-factor structure model fitted the data well(x2/df=2.82,RMSEA=0.06,CFI=0.92,GFI=0.85,TLI=0.91).The total scores and factor scores of the SSSDA were positively correlated with the DSTS scores(ICC=0.10-0.22,Ps＜0.05).The Cronbach α coefficients for the total scale and each dimension were between 0.80 and 0.95,and the test-retest reliability coefficients(ICC)were between 0.82 and 0.94.Conclusion:The Self-stigma Scale for Drug Addicts(SSSDA)initially developed in this study has satisfactory reliability and validity.

Objective:To explore the factors influencing electronically-delivered cognitive behavioral therapy for insomnia (e-CBTI) selection among patients with insomnia, and to provide empirical evidence for the clinical promotion of e-CBTI.Methods:Between November 2022 and July 2023, a convenience sampling method was employed to collect samples from 38 public hospitals and their surrounding communities. A total of 756 insomnia patients aged 18-65 years were included in the study. Based on their choice to participate in e-CBTI treatment, patients were divided into two groups: 605 patients (605/756,80.0%) chose to participate in e-CBTI treatment, while 151 patients (151/756,20.0%) did not. Rater-rated structured clinical interviews were applied in the current study, assessing individual′s insomnia symptoms, mental disorders, other sleep disorders, and suicidality and self-injury. The chi-square test and logistic regression were applied in data analyses.Results:Compared to the control group, the e-CBTI group had a higher proportion of females (χ 2=4.29) and a higher educational level (χ 2=5.76), while the proportion of living in rural areas was lower (χ 2=6.87), all with P<0.05. Additionally, the e-CBTI group exhibited a higher proportion of daytime symptoms compared to the control group, including decreased attention or memory (χ 2=16.42), impaired function or performance (χ 2=6.75), mood changes (χ 2=4.71), and reduced enthusiasm, energy, or motivation (χ 2=4.77), all with P<0.05. The e-CBTI group also showed a higher tendency for delayed sleep phase (χ 2=6.61), generalized anxiety disorder (χ 2=6.22), suicidal ideation (χ 2=10.45), and non-suicidal self-injury (χ 2=5.19), all with statistically significant differences ( P<0.05). Multivariate logistic regression analysis revealed that the type of residence ( OR=0.53, 95 %CI=0.29-0.95), educational level ( OR=2.42, 95 %CI=1.34-4.37), decreased attention or memory ( OR=1.95, 95 %CI=1.11-3.42), impaired function or performance ( OR=1.80, 95 %CI=1.15-2.82), and suicidal ideation ( OR=3.12, 95 %CI=1.29-7.58) remained significant influential factors in the selection of e-CBTI. Insomnia′s nighttime symptoms, including difficulty falling asleep, difficulty maintaining sleep, and early morning awakenings, were not associated with the inclination to choose e-CBTI. Conclusions:Daytime symptoms of insomnia and suicidal ideation are significant factors that prompt insomnia patients to choose e-CBTI.

Objective This article takes a cosmetics factory in Yichang City as an example, uses a variety of methodologies to explore methods of health impact assessment and provides methodological references for future health evaluation of related public policies. Methods By analyzing the environmental assessment report of the cosmetic renovation project, an indicator system was established and expert consultation meetings were conducted to score the impact of the corresponding indicators on health. The impact of the renovation project of the factory on the factory workers, surrounding residents and the sustainable development of the environment was analyzed by means of the Kaiser model with the risk matrix and the Borda value. Results The risk values of the five influencing factors of industrial wastewater, domestic wastewater, industrial waste gas, industrial waste and noise were 5.11%, 5.43%, 10.6%, 6.71% and 7.02% respectively. All the influencing factors were in the green zone of the risk matrix. The Borda values of the five influencing factors of industrial waste water, domestic waste water, industrial waste gas, industrial waste residue and noise were 4, 5, 10, 7 and 5 respectively. Conclusion The multiple methodologies adopted in the factory renovation project are feasible, and can provide new ideas for the health impact assessment of public policies in the future.

Objective To observe the adverse effects of 0.01％ atropine sulfate eye drops on myopic children.Methods A prospective non-randomized controlled trial was conducted.Ninety-nine myopic children (99 right eyes) were randomly assigned to experimental group(55 cases) and control group(44 cases).Myopic children of experimental group wore completely corrected frame glasses,while 0.01％ atropine sulfate eye drop was dropped into each eye once a day before going to bed.Myopic children in control group only wore completely corrected frame glasses.The follow-up time was 4 months.Best corrected visual acuity (BCVA),intraocular pressure (IOP),change of pupil diameter (PD) and amplitude of accommodation,symptoms of discomfort after medication were observed.This study followed the Helsinki declaration and was approved by Ethic Committee of the First Affiliated Hospital of Zhengzhou University.Informed consent was signed by the parents of each patient.Results No significant differences were found in best corrected distance visual acuity (BCDVA),best corrected near visual acuity(BCNVA) and IOP between the two groups before and 4 months after treatment (BCDVA:Fgroup =3.880,P =0.112;Ftime =27.220,P =0.413;BCNVA:Fgroup =5.200,P =0.311;Ftime =38.200,P =0.116,IOP:Fgroup =12.350,P=0.214;Ftime =22.300,P =0.146).After 4 months treatment,the PD was (6.99 ±0.64) mm in the experimental group,which was significantly higher than that before treatment(P＜0.001).The PD of the experimental group was higher than that of the control group after 4 months treatment,and the difference was statistically significant (P＜0.01).The amplitude of accommodation in the experimental group was 14.01 ±3.98 after 4 months treatment.which was 1.20 D lower than that before treatment,the difference was statistically significant (P＜0.01).The amplitude of accommodation of the experimental group was lower than that of the control group after 4 months treatment,the difference was statistically significant (P ＜ 0.01).Four cases (8％) appeared photophobia symptoms.Two cases and 2 cases appeared photophobia for 1 week or 2 weeks,respectively.However this symptom would relieve after wear sunglasses or sunshade caps in outdoor activities.One case (2％) appeared ocular itching and swelling after 1 month treatment,but disappeared after withdrawal.There were no other uncomfortable symptoms such as near sight blurring.Conclusions In mainland of China,the BCDVA,BCNVA and IOP of myopic children are stable;the PD is dilated and the amplitude of accommodation is decreased slightly after 4 months treatment of 0.01％ atropine,and 10％ children appear photophobia,but do not affect their study and life.

Objective To investigate the main risk factors induced to coronary artery stenosis in order to provide evidence for prevention of coronary heart disease in flying personnel. Methods By analyzing the computed tomography angiography (CTA) ,44 flying personnel clinically suspected as coronary heart disease were divided into coronary artery stenosis group and normal coronary artery group.The comparisons on age ,flying aircraft type ,flying duties ,body mass index (BMI) ,flying hours ,night flying hours , blood lipid level , serum glucose level , histories of hypertension and smoking were conducted between two groups.The Logistic multivariate regression analysis was used for determining risk factors. Results The CTA results indicated 25 cases (56.82%) of coronary artery stenosis and 19 normal cases.The univariate analysis showed the statistical differences on age , flight hours , night flight hours , and the incidences of hypercholesterolemia , hyper low-density lipoprotein cholesterolemia , Hypo high-density lipoprotein cholesterolemia and hypertriglyceridemia between coronary artery stenosis group and coronary artery normal group (χ2＝4.429-14.329 , P＜ 0.05 ).The Logistic multivariate regression analysis showed that hyper low-density lipoprotein cholesterolemia (OR＝7.026 ,95% CI :1.831-26.959 ,P＜0.05) and night flight hours (OR＝4.461 , 95% CI :1.694-11.746 , P ＜ 0.05) were the independent risk factors of coronary artery stenosis. Conclusions Hyper low-density lipoprotein cholesterolemia and night flying hours are the independent risk factors of coronary artery stenosis in pilots.These hint that the change of circadian rhythms would be an important factor to induce coronary artery stenosis besides the common risk factors.

Objective To investigate the main risk factors induced to coronary artery stenosis in order to provide evidence for prevention of coronary heart disease in flying personnel. Methods By analyzing the computed tomography angiography (CTA) ,44 flying personnel clinically suspected as coronary heart disease were divided into coronary artery stenosis group and normal coronary artery group.The comparisons on age ,flying aircraft type ,flying duties ,body mass index (BMI) ,flying hours ,night flying hours , blood lipid level , serum glucose level , histories of hypertension and smoking were conducted between two groups.The Logistic multivariate regression analysis was used for determining risk factors. Results The CTA results indicated 25 cases (56.82%) of coronary artery stenosis and 19 normal cases.The univariate analysis showed the statistical differences on age , flight hours , night flight hours , and the incidences of hypercholesterolemia , hyper low-density lipoprotein cholesterolemia , Hypo high-density lipoprotein cholesterolemia and hypertriglyceridemia between coronary artery stenosis group and coronary artery normal group (χ2＝4.429-14.329 , P＜ 0.05 ).The Logistic multivariate regression analysis showed that hyper low-density lipoprotein cholesterolemia (OR＝7.026 ,95% CI :1.831-26.959 ,P＜0.05) and night flight hours (OR＝4.461 , 95% CI :1.694-11.746 , P ＜ 0.05) were the independent risk factors of coronary artery stenosis. Conclusions Hyper low-density lipoprotein cholesterolemia and night flying hours are the independent risk factors of coronary artery stenosis in pilots.These hint that the change of circadian rhythms would be an important factor to induce coronary artery stenosis besides the common risk factors.

Objective To investigate the specific immune therapeutic effect of the T cell fusion peptide vaccine from group II allergens from Dermatophagoides pteronyssinus(Der p2). Methods Thirty mice were randomly divided into three groups, namely a negative control group(a PBS group),positive control group(an asthma group)and protein Der p2 T cell fusion epit?ope for specific immunotherapy(SIT)group(a Der p2 T group). The extract of house dust mites(HDM)was used to establish the asthmatic models in BALB/c mice,and the PBS group was always used with PBS buffer. Thirty minutes before spray inhala?tion from 25 to 27 days,the mice of the Der p2 T group were respectively injected subcutaneously with the therapeutic proteins for SIT,then the serum and bronchoalveolar lavage fluid(BALF)were collected. ELISA was used to assay the levels of IFN?γ, IL?4,and IL?13 in BALF,as well as serum levels of specific IgE and IgG2a. The lung tissue sections were stained with haematox?ylin and eosin(H&E)for pathological examinations. Results The ELISA detection revealed that the number of eosinophil in BALF of the asthmatic mice was(5.57 ± 0.64)× 105/ml,which was significantly higher than that in the PBS group[(0.50 ± 0.30)× 105/ml,P < 0.01],the number of eosinophil in the Der p2 T immunotherapy group decreased significantly[(3.45 ± 0.36)×105/ml,P<0.01]. The content of IFN?γin the PBS group,asthma group and Der p2 T group were(267.00 ± 21.98), (155.80 ± 20.53)pg/ml and(234.40 ± 24.46)pg/ml respectively. Compared with the asthma group,the mice with Der p2 T vac?cine specific immune treatment produced a high level of IFN?γ(P<0.01). The content of IL?4 in the PBS group,asthma group and Der p2 T group were(23.40 ± 5.96),(53.28 ± 8.26)pg/ml and(30.00 ± 5.50)pg/ml respectively. Compared with the asth?ma group,the content of IL?4 in the mice of the Der p2 T treatment group was significantly lower(P<0.01). Compared with the asthma group[(308.10 ± 28.32)pg/ml],the content of IL?13 in BALF of the mice in the Der p2 T treatment group was signifi?cantly decreased,which was[(174.50 ± 25.99)pg/ml,P<0.01]. The content of IL?13 in the PBS group was(95.99 ± 31.14) pg/ml. The lung tissue sections showed that the lung inflammation in the p2 T Der group was significantly less than that in the asthma group,and the inflammatory cell infiltration was significantly decreased,and airway epithelial construction remodeled. Conclusion The Der p2 T cell fusion epitope,which is as vaccines for specific immunotherapy with asthma models,can allevi?ate effectively allergic inflammation of airway and lung in the mice,and it may be used as a candidate vaccine for asthma.