Objective To investigate the relationship between traditional Chinese medicine(TCM)syndromes and biological indicators of neutrophil-to-lymphocyte ratio(NLR),systemic immune-inflammatory index(SII),systemic inflammation response index(SIRI),and aggregate index of systemic inflammation(AISI)in obese type 2 diabetes mellitus(T2DM)patients complicated with Helicobacter pylori(Hp)infection.Methods From January 2023 to July 2024,an investigation was carried out in 200 cases of obese T2DM patients complicated with Hp infection,20 cases of obese T2DM patients without Hp infection(Hp-negative),and 20 obese individuals without Hp infection(Hp-negative)who met the inclusion criteria and were treated at Linhai Hospital of Traditional Chinese Medicine.The relationships between different groups of obese individuals and biological indicators of NLR,SII,SIRI,and AISI were observed.And the correlation of TCM syndromes and the presence of chronic complications with biological indicators of NLR,SII,SIRI,and AISI in obese T2DM patients complicated with Hp infection was also explored.Results(1)The levels of NLR,SII,SIRI,and AISI in obese T2DM patients complicated with Hp infection were higher than those in obese T2DM patients(Hp-negative)and obese individuals(Hp-negative)(P＜0.05).(2)Among the 200 cases of obese T2DM patients with Hp infection,the distribution of TCM syndromes in descending order was as follows:phlegm-turbidity blocking the middle energizer syndrome(29.50%)＞phlegm blended with heat syndrome(21.50%)＞qi stagnation and blood stasis syndrome(20.00%)＞liver depression and spleen deficiency syndrome(19.00%)＞qi and yin deficiency syndrome(10.00%).(3)The levels of NLR,SII,SIRI,and AISI varied in obese T2DM patients with Hp infection of various TCM syndrome types,and they were in descending order in the following types:phlegm blended with heat syndrome＞qi stagnation and blood stasis syndrome＞liver depression and spleen deficiency syndrome＞phlegm-turbidity blocking the middle energizer syndrome＞qi and yin deficiency syndrome(P＜0.05).(4)Logistic regression analysis showed that NLR,SII,SIRI,and AISI were the risk factors of chronic complications in obese T2DM patients complicated with Hp infection,and all were positively correlated with the chronic complications(P＜0.05 or P＜0.01).Conclusion NLR,SII,SIRI,and AISI are correlated with the severity of obese T2DM complicated with Hp infection,which may serve as potential biological indicators for TCM syndrome differentiation and identification of chronic complications in obese T2DM patients complicated with Hp infection.

[Objective]To investigate the correlation between traditional Chinese Medicine(TCM)syndrome types in patients with diabetic nephropathy(DN)and leukocyte lymphocyte ratio(WLR),platelet/lymphocyte ratio(PLR),monocyte lymphocyte ratio(MLR).[Methods]A total of 227 patients with DN and AS were included in this study to analyze the changes of WLR,PLR,MLR,carotid intima-medial thickness(IMT)and the levels of WLR,PLR and MLR under different TCM syndrome types.Logistic analysis and receiver operating characteristic(ROC)curves were used to evaluate the application value of WLR,PLR and MLR in predicting the severity and prognosis of DN complicated with AS.[Results]Among the TCM syndrome types in patients with DN and AS,Qi and Yin deficiency syndrome accounted for the highest proportion,followed by spleen and kidney Yang deficiency syndrome,Yin and Yang deficiency syndrome,and turbidity and stasis obstruction syndrome.The levels of WLR,PLR,and MLR in patients with DN and AS from high to low were turbidity and stasis obstruction syndrome,Yin and Yang deficiency syndrome,spleen and kidney Yang deficiency syndrome,and Qi and Yin deficiency syndrome.WLR,PLR,MLR were positively correlated with IMT(P<0.05).Logistic analysis showed that the levels of WLR,PLR and MLR were correlated with the severity of DN and AS.ROC curve analysis indicated WLR,PLR,MLR had high value in evaluating the prognosis of DN combined with AS(P<0.05).[Conclusion]WLR,PLR and MLR are expected to be potential biological indicators for microscopic syndrome differentiation and prognosis evaluation of DN combined with AS in TCM.

[Objective]To investigate the correlation between traditional Chinese Medicine(TCM)syndrome types in patients with diabetic nephropathy(DN)and leukocyte lymphocyte ratio(WLR),platelet/lymphocyte ratio(PLR),monocyte lymphocyte ratio(MLR).[Methods]A total of 227 patients with DN and AS were included in this study to analyze the changes of WLR,PLR,MLR,carotid intima-medial thickness(IMT)and the levels of WLR,PLR and MLR under different TCM syndrome types.Logistic analysis and receiver operating characteristic(ROC)curves were used to evaluate the application value of WLR,PLR and MLR in predicting the severity and prognosis of DN complicated with AS.[Results]Among the TCM syndrome types in patients with DN and AS,Qi and Yin deficiency syndrome accounted for the highest proportion,followed by spleen and kidney Yang deficiency syndrome,Yin and Yang deficiency syndrome,and turbidity and stasis obstruction syndrome.The levels of WLR,PLR,and MLR in patients with DN and AS from high to low were turbidity and stasis obstruction syndrome,Yin and Yang deficiency syndrome,spleen and kidney Yang deficiency syndrome,and Qi and Yin deficiency syndrome.WLR,PLR,MLR were positively correlated with IMT(P<0.05).Logistic analysis showed that the levels of WLR,PLR and MLR were correlated with the severity of DN and AS.ROC curve analysis indicated WLR,PLR,MLR had high value in evaluating the prognosis of DN combined with AS(P<0.05).[Conclusion]WLR,PLR and MLR are expected to be potential biological indicators for microscopic syndrome differentiation and prognosis evaluation of DN combined with AS in TCM.